Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

Zhu Chen, Sai-Juan Chen and colleagues report exome sequencing of acute monocytic leukemia, a subtype of acute myeloid leukemia. They identified somatic mutations of DNMT3A , which encodes a DNA methyltransferase, in 20% of cases. Abnormal epigenetic regulation has been implicated in oncogenesis. We...

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Veröffentlicht in:	Nature genetics 2011-04, Vol.43 (4), p.309-315
Hauptverfasser:	Yan, Xiao-Jing, Xu, Jie, Gu, Zhao-Hui, Pan, Chun-Ming, Lu, Gang, Shen, Yang, Shi, Jing-Yi, Zhu, Yong-Mei, Tang, Lin, Zhang, Xiao-Wei, Liang, Wen-Xue, Mi, Jian-Qing, Song, Huai-Dong, Li, Ke-Qin, Chen, Zhu, Chen, Sai-Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/2487/2486 631/208/737 692/699/67/1990/283/1897 Adult Aged Agriculture Amino Acid Sequence Amino Acid Substitution Animal Genetics and Genomics Base Sequence Biological and medical sciences Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Bone marrow Cancer Research Cell cycle Conserved Sequence Deoxyribonucleic acid Disease DNA DNA (Cytosine-5-)-Methyltransferases - chemistry DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation - genetics DNA, Complementary - genetics Enzymatic activity Exons Experiments Female Fundamental and applied biological sciences. Psychology Gene expression Gene Function Genetic aspects Genetic testing Genetics of eukaryotes. Biological and molecular evolution Genomes Hematologic and hematopoietic diseases Histone-Lysine N-Methyltransferase Human Genetics Humans Kaplan-Meier Estimate Leukemia Leukemia, Monocytic, Acute - enzymology Leukemia, Monocytic, Acute - genetics Leukemia, Myeloid, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytic leukemia Male Medical prognosis Medical sciences Methyltransferases Middle Aged Models, Molecular Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - genetics Mutation Mutation, Missense Myeloid-Lymphoid Leukemia Protein - genetics Physiological aspects Prognosis Risk factors Sequence Homology, Amino Acid
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