P38-Nrf-2 Signaling Pathway of Oxidative Stress in Mice Caused by Nanoparticulate TiO2

Some recent studies have been previously suggested that nanoparticulate titanium dioxide (TiO2) damaged liver function and decreased immunity of mice, but the spleen injury and its oxidative stress mechanism are still unclear. To understand the spleen injury induced by intragastric administration of...

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Veröffentlicht in:	Biological trace element research 2011-05, Vol.140 (2), p.186-197
Hauptverfasser:	Wang, Jue, Li, Na, Zheng, Lei, Wang, Sisi, Wang, Ying, Zhao, Xiaoyang, Duan, Yanmei, Cui, Yaling, Zhou, Min, Cai, Jingwei, Gong, Songjie, Wang, Han, Hong, Fashui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biotechnology Female heme oxygenase (decyclizing) immunity intragastric administration Kinases Life Sciences Lipid Peroxidation liver function lymph Metal Nanoparticles - chemistry Mice Mice, Inbred ICR mitogen-activated protein kinase NF-E2-Related Factor 2 - metabolism Nutrition Oncology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology p38 Mitogen-Activated Protein Kinases - metabolism Pathology Peroxidation reactive oxygen species Rodents Signal Transduction Spleen Titanium - pharmacology Titanium dioxide toxicity Trace elements
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