Stimulation of angiogenesis in rat ischemic limbby intramuscular implantation of mononuclear fraction cells from autologous bone marrow
We studied angiogenic effects of two variants of indirect revascularization (transplantation of mononuclear fraction cells from autologous bone marrow alone or in combination with laser tunneling) after modeled ischemia of the lower limbs in rats. Doppler sonography and immunofl uorescence studies s...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2011-02, Vol.150 (4), p.530-534 |
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| creator | Larionov, P. M Chernyavskii, A. M Novruzov, R. B Lushnikova, E. L Subbotin, D. V Sergeevichev, D. S Kuznetsova, I. V Karas'kov, A. M Nepomnyashchikh, L. M |
| description | We studied angiogenic effects of two variants of indirect revascularization (transplantation of mononuclear fraction cells from autologous bone marrow alone or in combination with laser tunneling) after modeled ischemia of the lower limbs in rats. Doppler sonography and immunofl uorescence studies showed that intramuscular implantation of isolated fraction of autologous bone marrow mononuclear cells in combination with laser tunneling of the muscles is most effective and can be recommended as a method of angiogenesis stimulation in nonreconstructable distal vascular pathology of the extremities. |
| doi_str_mv | 10.1007/s10517-011-1183-5 |
| format | Article |
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M ; Chernyavskii, A. M ; Novruzov, R. B ; Lushnikova, E. L ; Subbotin, D. V ; Sergeevichev, D. S ; Kuznetsova, I. V ; Karas'kov, A. M ; Nepomnyashchikh, L. M</creator><creatorcontrib>Larionov, P. M ; Chernyavskii, A. M ; Novruzov, R. B ; Lushnikova, E. L ; Subbotin, D. V ; Sergeevichev, D. S ; Kuznetsova, I. V ; Karas'kov, A. M ; Nepomnyashchikh, L. M</creatorcontrib><description>We studied angiogenic effects of two variants of indirect revascularization (transplantation of mononuclear fraction cells from autologous bone marrow alone or in combination with laser tunneling) after modeled ischemia of the lower limbs in rats. Doppler sonography and immunofl uorescence studies showed that intramuscular implantation of isolated fraction of autologous bone marrow mononuclear cells in combination with laser tunneling of the muscles is most effective and can be recommended as a method of angiogenesis stimulation in nonreconstructable distal vascular pathology of the extremities.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-011-1183-5</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; bone marrow mononuclear fraction ; Cell Biology ; fluorescent antibody technique ; Internal Medicine ; ischemia of extremities ; Laboratory Medicine ; laser tunneling of muscles ; Pathology ; revascularization ; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)</subject><ispartof>Bulletin of experimental biology and medicine, 2011-02, Vol.150 (4), p.530-534</ispartof><rights>Springer Science+Business Media, Inc. 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1845-835d739eb83d1737331fc5395936b643141b10e9e3e97098a99b4d81ed2b68493</citedby><cites>FETCH-LOGICAL-c1845-835d739eb83d1737331fc5395936b643141b10e9e3e97098a99b4d81ed2b68493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-011-1183-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-011-1183-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids></links><search><creatorcontrib>Larionov, P. 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| subjects | Biomedical and Life Sciences Biomedicine bone marrow mononuclear fraction Cell Biology fluorescent antibody technique Internal Medicine ischemia of extremities Laboratory Medicine laser tunneling of muscles Pathology revascularization Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) |
| title | Stimulation of angiogenesis in rat ischemic limbby intramuscular implantation of mononuclear fraction cells from autologous bone marrow |
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