Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-[Beta]-induced senescence of human bronchial epithelial cells

Reepithelialization of remodeled air spaces with bronchial epithelial cells is a prominent pathological finding in idiopathic pulmonary fibrosis (IPF) and is implicated in IPF pathogenesis. Recent studies suggest that epithelial senescence is a risk factor for development of IPF, indicating such ree...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2011-03, Vol.300 (3), p.L391
Hauptverfasser:	Minagawa, Shunsuke, Araya, Jun, Numata, Takanori, Nojiri, Satoko, Hara, Hiromichi, Yumino, Yoko, Kawaishi, Makoto, Odaka, Makoto, Morikawa, Toshiaki, Nishimura, Stephen L, Nakayama, Katsutoshi, Kuwano, Kazuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell growth Cystic fibrosis Gene expression Pathogenesis Physiology Proteins Respiratory diseases
Online-Zugang:	Volltext
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