Effects of N-Acetylcysteine on Renal Hemodynamics in Contrast Media-Induced Nephropathy
Background: N-acetylcysteine (NAC) has been proposed to prevent radiocontrast nephropathy in high-risk patients. Methods: The effect of single-dose and prolonged administration of NAC before application of either the ionic, high-osmolar radiocontrast agent diatrizoate sodium (DTZ) or the nonionic, l...
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| Veröffentlicht in: | Kidney & blood pressure research 2011-01, Vol.34 (2), p.125-134 |
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| creator | Krzossok, Stefan Braun, Claude Weiss, Elizabeth Hoeger, Simone Schnuelle, Peter Benck, Urs Birck, Rainer Krämer, Bernhard K. Göttmann, Uwe |
| description | Background: N-acetylcysteine (NAC) has been proposed to prevent radiocontrast nephropathy in high-risk patients. Methods: The effect of single-dose and prolonged administration of NAC before application of either the ionic, high-osmolar radiocontrast agent diatrizoate sodium (DTZ) or the nonionic, low-osmolar radiocontrast agent iohexol (IOH) in a rat model combining uninephrectomy, salt depletion, and administration of indomethacin was explored. Arterial blood pressure and total, cortical, and medullary blood flow were continuously recorded in anesthetized Sprague-Dawley rats. Results: NAC had no effect on renal hemodynamics in control rats. Both DTZ and IOH induced biphasic changes in renal blood flow and cortical renal blood flux and persistently reduced medullary blood flux. Neither single-dose nor prolonged administration of NAC prevented the hemodynamic changes following administration of DTZ or IOH, respectively. Acute prophylactic administration of NAC prevented increased urinary ET excretion after injection of IOH and, to a smaller degree, of DTZ. Both an ionic, high-osmolar (DTZ) and a nonionic, low-osmolar (IOH) radiocontrast agent induce marked changes in renal hemodynamics in salt-depleted rats treated with indomethacin. Conclusions: Renal perfusion is not affected by NAC application in a model of experimental contrast nephropathy in rats. Other effects of NAC might thus account for the presumed renoprotective properties. |
| doi_str_mv | 10.1159/000324168 |
| format | Article |
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Methods: The effect of single-dose and prolonged administration of NAC before application of either the ionic, high-osmolar radiocontrast agent diatrizoate sodium (DTZ) or the nonionic, low-osmolar radiocontrast agent iohexol (IOH) in a rat model combining uninephrectomy, salt depletion, and administration of indomethacin was explored. Arterial blood pressure and total, cortical, and medullary blood flow were continuously recorded in anesthetized Sprague-Dawley rats. Results: NAC had no effect on renal hemodynamics in control rats. Both DTZ and IOH induced biphasic changes in renal blood flow and cortical renal blood flux and persistently reduced medullary blood flux. Neither single-dose nor prolonged administration of NAC prevented the hemodynamic changes following administration of DTZ or IOH, respectively. Acute prophylactic administration of NAC prevented increased urinary ET excretion after injection of IOH and, to a smaller degree, of DTZ. Both an ionic, high-osmolar (DTZ) and a nonionic, low-osmolar (IOH) radiocontrast agent induce marked changes in renal hemodynamics in salt-depleted rats treated with indomethacin. Conclusions: Renal perfusion is not affected by NAC application in a model of experimental contrast nephropathy in rats. Other effects of NAC might thus account for the presumed renoprotective properties.</description><identifier>ISSN: 1420-4096</identifier><identifier>EISSN: 1423-0143</identifier><identifier>DOI: 10.1159/000324168</identifier><identifier>PMID: 21335974</identifier><identifier>CODEN: RPBIEL</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acetylcysteine - pharmacology ; Acetylcysteine - therapeutic use ; Animals ; Contrast Media - adverse effects ; Hemodynamics - drug effects ; Kidney - blood supply ; Kidney Diseases - chemically induced ; Kidney Diseases - prevention & control ; Original Paper ; Rats ; Rats, Sprague-Dawley ; Renal Circulation - drug effects</subject><ispartof>Kidney & blood pressure research, 2011-01, Vol.34 (2), p.125-134</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-d971fc6ca6adeb8ae2e4ddc97097eb8764163189595ec12cc3d88d5f6d713e693</citedby><cites>FETCH-LOGICAL-c367t-d971fc6ca6adeb8ae2e4ddc97097eb8764163189595ec12cc3d88d5f6d713e693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21335974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krzossok, Stefan</creatorcontrib><creatorcontrib>Braun, Claude</creatorcontrib><creatorcontrib>Weiss, Elizabeth</creatorcontrib><creatorcontrib>Hoeger, Simone</creatorcontrib><creatorcontrib>Schnuelle, Peter</creatorcontrib><creatorcontrib>Benck, Urs</creatorcontrib><creatorcontrib>Birck, Rainer</creatorcontrib><creatorcontrib>Krämer, Bernhard K.</creatorcontrib><creatorcontrib>Göttmann, Uwe</creatorcontrib><title>Effects of N-Acetylcysteine on Renal Hemodynamics in Contrast Media-Induced Nephropathy</title><title>Kidney & blood pressure research</title><addtitle>Kidney Blood Press Res</addtitle><description>Background: N-acetylcysteine (NAC) has been proposed to prevent radiocontrast nephropathy in high-risk patients. Methods: The effect of single-dose and prolonged administration of NAC before application of either the ionic, high-osmolar radiocontrast agent diatrizoate sodium (DTZ) or the nonionic, low-osmolar radiocontrast agent iohexol (IOH) in a rat model combining uninephrectomy, salt depletion, and administration of indomethacin was explored. Arterial blood pressure and total, cortical, and medullary blood flow were continuously recorded in anesthetized Sprague-Dawley rats. Results: NAC had no effect on renal hemodynamics in control rats. Both DTZ and IOH induced biphasic changes in renal blood flow and cortical renal blood flux and persistently reduced medullary blood flux. Neither single-dose nor prolonged administration of NAC prevented the hemodynamic changes following administration of DTZ or IOH, respectively. Acute prophylactic administration of NAC prevented increased urinary ET excretion after injection of IOH and, to a smaller degree, of DTZ. Both an ionic, high-osmolar (DTZ) and a nonionic, low-osmolar (IOH) radiocontrast agent induce marked changes in renal hemodynamics in salt-depleted rats treated with indomethacin. Conclusions: Renal perfusion is not affected by NAC application in a model of experimental contrast nephropathy in rats. Other effects of NAC might thus account for the presumed renoprotective properties.</description><subject>Acetylcysteine - pharmacology</subject><subject>Acetylcysteine - therapeutic use</subject><subject>Animals</subject><subject>Contrast Media - adverse effects</subject><subject>Hemodynamics - drug effects</subject><subject>Kidney - blood supply</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - prevention & control</subject><subject>Original Paper</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Renal Circulation - drug effects</subject><issn>1420-4096</issn><issn>1423-0143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0EFLwzAUB_AgipvTg3eR4EU8VJOmTZrjGNMN5gRRPJYseXWdbVOT9tBvb93mDp7ee_B7D94foUtK7imN5QMhhIUR5ckRGtIoZAGhETve9iSIiOQDdOb9pmcxIeEpGoSUsViKaIg-plkGuvHYZngZjDU0XaE730BeAbYVfoVKFXgGpTVdpcpce5xXeGKrxinf4GcwuQrmlWk1GLyEeu1srZp1d45OMlV4uNjXEXp_nL5NZsHi5Wk-GS8CzbhoAiMFzTTXiisDq0RBCJExWgoiRT8L3n_FaCJjGYOmodbMJImJM24EZcAlG6Hb3d3a2e8WfJOWuddQFKoC2_o0ibngUoSslzf_5Ma2rv9uixJCY5L06G6HtLPeO8jS2uWlcl1KSfqbdXrIurfX-4PtqgRzkH_h9uBqB76U-wR3APv9H8G4gWA</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Krzossok, Stefan</creator><creator>Braun, Claude</creator><creator>Weiss, Elizabeth</creator><creator>Hoeger, Simone</creator><creator>Schnuelle, Peter</creator><creator>Benck, Urs</creator><creator>Birck, Rainer</creator><creator>Krämer, Bernhard K.</creator><creator>Göttmann, Uwe</creator><general>S. 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Methods: The effect of single-dose and prolonged administration of NAC before application of either the ionic, high-osmolar radiocontrast agent diatrizoate sodium (DTZ) or the nonionic, low-osmolar radiocontrast agent iohexol (IOH) in a rat model combining uninephrectomy, salt depletion, and administration of indomethacin was explored. Arterial blood pressure and total, cortical, and medullary blood flow were continuously recorded in anesthetized Sprague-Dawley rats. Results: NAC had no effect on renal hemodynamics in control rats. Both DTZ and IOH induced biphasic changes in renal blood flow and cortical renal blood flux and persistently reduced medullary blood flux. Neither single-dose nor prolonged administration of NAC prevented the hemodynamic changes following administration of DTZ or IOH, respectively. Acute prophylactic administration of NAC prevented increased urinary ET excretion after injection of IOH and, to a smaller degree, of DTZ. Both an ionic, high-osmolar (DTZ) and a nonionic, low-osmolar (IOH) radiocontrast agent induce marked changes in renal hemodynamics in salt-depleted rats treated with indomethacin. Conclusions: Renal perfusion is not affected by NAC application in a model of experimental contrast nephropathy in rats. Other effects of NAC might thus account for the presumed renoprotective properties.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>21335974</pmid><doi>10.1159/000324168</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcysteine - pharmacology Acetylcysteine - therapeutic use Animals Contrast Media - adverse effects Hemodynamics - drug effects Kidney - blood supply Kidney Diseases - chemically induced Kidney Diseases - prevention & control Original Paper Rats Rats, Sprague-Dawley Renal Circulation - drug effects |
| title | Effects of N-Acetylcysteine on Renal Hemodynamics in Contrast Media-Induced Nephropathy |
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