Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-[Beta]

Phagocytosed Borrelia burgdorferi (Bb) induces inflammatory signals that differ both quantitatively and qualitatively from those generated by spirochetal lipoproteins interacting with Toll-like receptor (TLR) 1/2 on the surface of human monocytes. Of particular significance, and in contrast to lipop...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-03, Vol.108 (9), p.3683
Hauptverfasser:	Cervantes, Jorge L, Dunham-Ems, Star M, J Carson La Vake, Petzke, Mary M, Sahay, Bikash, Sellati, Timothy J, Radolf, Justin D, Salazar, Juan C
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Cells Cytokines Interferon Lipoproteins Microscopy Molecules Signal transduction T cell receptors
Online-Zugang:	Volltext
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