Hypoxia-inducible factor 2[alpha] (HIF-2[alpha]) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension

Cardiorespiratory functions in mammals are exquisitely sensitive to changes in arterial O2 levels. Hypoxia-inducible factors (e.g., HIF-1 and HIF-2) mediate transcriptional responses to reduced oxygen availability. We demonstrate that haploinsufficiency for the O2-regulated HIF-2α subunit results in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (7), p.3065
Hauptverfasser:	Peng, Ying-Jie, Nanduri, Jayasri, Khan, Shakil A, Yuan, Guoxiang, Wang, Ning, Kinsman, Brian, Vaddi, Damodara R, Kumar, Ganesh K, Garcia, Joseph A, Semenza, Gregg L, Prabhakar, Nanduri R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Enzymes Gene expression Hypoxia Oxygen Proteins Rodents
Online-Zugang:	Volltext
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