The Changes of Bone-Specific Alkaline Phosphatase (BsALP) Associated With Callus Formation and Rate of Bone Healing

The aim of this study was to examine whether the volume of bone-specific alkaline phosphatase (BsALP) as a biochemical parameter in the early posttraumatic phase may indicate the speed of fracture healing. The evaluation of the bone healing process has been based on the patient's subjective statement and radiographic findings. The activity of bone-specific alkaline phosphatase has been measured in the sera of 41 patients who have been diagnosed with fractures of long bones. All the patients have been surgically treated. The activity of BsALP was measured on each seventh day during a four-week period. On the same patients the radiologically follow-up tests have been made during a period of seven months. Our research has shown that the increase of alkaline phosphatase correlates with an increase of BsALP levels. The volume of callus correlates with the level of ALP and BsALP. The result leads us to a conclusion that by monitoring the changes of biochemical parameters: alkaline phosphatase and bone-specific alcaline phosphatase, we can be able to predict the dynamics of the bone healing. [PUBLICATION ABSTRACT]