Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population
Background: Apolipoprotein E (APOE) is known as a major regulator of blood lipid levels in humans. A number of APOE gene allelic variants have been reported including E2, E3 and E4. Recent studies suggested a role for APOE in obesity and increased Body Mass Index (BMI) and plasma lipid levels in obe...
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| Veröffentlicht in: | Journal of postgraduate medicine 2010-07, Vol.56 (3), p.173-175 |
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| creator | Bazzaz, J. T Nazari, M Nazem, H Amiri, P Fakhrzadeh, H Heshmat, R Abbaszadeh, S Amoli, M. M |
| description | Background: Apolipoprotein E (APOE) is known as a major regulator of
blood lipid levels in humans. A number of APOE gene allelic variants
have been reported including E2, E3 and E4. Recent studies suggested a
role for APOE in obesity and increased Body Mass Index (BMI) and plasma
lipid levels in obese children. Aim: The aim of this study was to
examine the association between APOE genetic variants and the BMI and
lipid profile in an Iranian cohort. Setting and Design: Samples were
obtained from subjects who participated in a study based on the
WHO-designed MONICA (multinational monitoring of trends and
determinants in cardiovascular disease) study for coronary artery
disease risk assessment in Zone 17 of Tehran. The study was approved by
the local ethical committee. Informed consent was obtained from all
subjects included in this study. Materials and Methods: Subjects
(n=320) were recruited. The level of triglyceride (TG) and total serum
cholesterol was tested for all subjects in this study. Genotyping for
APOE was carried using polymerase chain reaction-Restriction fragment
length polymorphism (PCR-RFLP)technique. Statistical Analysis: Levels
of significance were determined using contingency tables by either
Chi-square or Fisher exact analysis using the STATA (v8) software. The
analysis of regression and significance of differences for level of
cholesterol and TG was established by one-way analysis of variance
followed by Dunnett post hoc multiple comparison tests using SPSS
software Version 11.5. Results: The frequency of allele E2 was
significantly higher in patients with total serum cholesterol level |
| doi_str_mv | 10.4103/0022-3859.68629 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_850815274</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A236219946</galeid><sourcerecordid>A236219946</sourcerecordid><originalsourceid>FETCH-LOGICAL-b508t-4130dd35474d38c11a2d9ffccc4d7bf939a5b714caf091573582693a673b3d903</originalsourceid><addsrcrecordid>eNptkc1rHCEYxqWkNB_tObcg6Xk2fo2OxyWkTSDQS3vpRRx1EhdHJzoTyH9ft5tNCCwKyuvveT98ADjHaMUwolcIEdLQrpUr3nEiP4ETJAVpSEfoUb3vX4_BaSkbhDDnjH4BxwQJKgVHJ-DvekrBT2nKaXY-whv44KKDNfgypjw9-jJCHS2c06wDLC4vIzSPKbgyu5wCDO7ZBViFd1lHr2NVTkvQs0_xK_g86FDct9fzDPz5cfP7-ra5__Xz7np93_Qt6uaGYYqspS0TzNLOYKyJlcNgjGFW9IOkUre9wMzoAUncCtp2hEuquaA9tRLRM3C5y1tneFpqY2qTlhxrSdXVCrglglXo-w560MEpH4c0Z21GX4xaE8oJlpLxSjUHqO2PZB1SdIOv4Q_86gBfl3WjNwcFVzuByamU7AY1ZT_q_KIwUltH1dYztfVM_Xe0Ki5ep1v60dk3fm_hew-9r05G90aY7LXaBzdT3Rgh1tF_EVOqgA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>850815274</pqid></control><display><type>article</type><title>Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population</title><source>MEDLINE</source><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Bazzaz, J. T ; Nazari, M ; Nazem, H ; Amiri, P ; Fakhrzadeh, H ; Heshmat, R ; Abbaszadeh, S ; Amoli, M. M</creator><creatorcontrib>Bazzaz, J. T ; Nazari, M ; Nazem, H ; Amiri, P ; Fakhrzadeh, H ; Heshmat, R ; Abbaszadeh, S ; Amoli, M. M</creatorcontrib><description>Background: Apolipoprotein E (APOE) is known as a major regulator of
blood lipid levels in humans. A number of APOE gene allelic variants
have been reported including E2, E3 and E4. Recent studies suggested a
role for APOE in obesity and increased Body Mass Index (BMI) and plasma
lipid levels in obese children. Aim: The aim of this study was to
examine the association between APOE genetic variants and the BMI and
lipid profile in an Iranian cohort. Setting and Design: Samples were
obtained from subjects who participated in a study based on the
WHO-designed MONICA (multinational monitoring of trends and
determinants in cardiovascular disease) study for coronary artery
disease risk assessment in Zone 17 of Tehran. The study was approved by
the local ethical committee. Informed consent was obtained from all
subjects included in this study. Materials and Methods: Subjects
(n=320) were recruited. The level of triglyceride (TG) and total serum
cholesterol was tested for all subjects in this study. Genotyping for
APOE was carried using polymerase chain reaction-Restriction fragment
length polymorphism (PCR-RFLP)technique. Statistical Analysis: Levels
of significance were determined using contingency tables by either
Chi-square or Fisher exact analysis using the STATA (v8) software. The
analysis of regression and significance of differences for level of
cholesterol and TG was established by one-way analysis of variance
followed by Dunnett post hoc multiple comparison tests using SPSS
software Version 11.5. Results: The frequency of allele E2 was
significantly higher in patients with total serum cholesterol level
<200 mg/dl (P 0.01 OR 2.1 95% CI 1.1-4.2). Conclusion: The
association found in this study between allele E2 and lower total
cholesterol level had been reported in previous studies. We have also
observed that the frequency of genotype E2/E3 and E2/E4 was
significantly higher in patients with normal total serum cholesterol
level compared to patients with abnormal cholesterol (P=0.003 OR 2.4
95% CI; 1.3-4.6). Our data needs to be repeated in a larger population
with more information for serum LDL and HDL levels and their subgroups.</description><identifier>ISSN: 0022-3859</identifier><identifier>EISSN: 0972-2823</identifier><identifier>DOI: 10.4103/0022-3859.68629</identifier><identifier>PMID: 20739760</identifier><language>eng</language><publisher>India: Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India</publisher><subject>Adult ; Alleles ; Apolipoprotein, cholesterol, diabetes ; Apolipoproteins ; Apolipoproteins E - genetics ; Arabs - genetics ; Blood cholesterol ; Body Mass Index ; Cardiovascular disease ; Cholesterol ; Cholesterol - blood ; Confidence intervals ; Deoxyribonucleic acid ; DNA ; Female ; Genetic polymorphisms ; Genotype ; Humans ; Hyperlipidemias - genetics ; Identification and classification ; Iran ; Lipids ; Low density lipoprotein ; Male ; Measurement ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length - genetics ; Properties ; Regression analysis ; Risk assessment ; Triglycerides - blood</subject><ispartof>Journal of postgraduate medicine, 2010-07, Vol.56 (3), p.173-175</ispartof><rights>Copyright 2010 Journal of Postgraduate Medicine.</rights><rights>COPYRIGHT 2010 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt. Ltd. Jul-Sep 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b508t-4130dd35474d38c11a2d9ffccc4d7bf939a5b714caf091573582693a673b3d903</citedby><cites>FETCH-LOGICAL-b508t-4130dd35474d38c11a2d9ffccc4d7bf939a5b714caf091573582693a673b3d903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79426</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20739760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bazzaz, J. T</creatorcontrib><creatorcontrib>Nazari, M</creatorcontrib><creatorcontrib>Nazem, H</creatorcontrib><creatorcontrib>Amiri, P</creatorcontrib><creatorcontrib>Fakhrzadeh, H</creatorcontrib><creatorcontrib>Heshmat, R</creatorcontrib><creatorcontrib>Abbaszadeh, S</creatorcontrib><creatorcontrib>Amoli, M. M</creatorcontrib><title>Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population</title><title>Journal of postgraduate medicine</title><addtitle>J Postgrad Med</addtitle><description>Background: Apolipoprotein E (APOE) is known as a major regulator of
blood lipid levels in humans. A number of APOE gene allelic variants
have been reported including E2, E3 and E4. Recent studies suggested a
role for APOE in obesity and increased Body Mass Index (BMI) and plasma
lipid levels in obese children. Aim: The aim of this study was to
examine the association between APOE genetic variants and the BMI and
lipid profile in an Iranian cohort. Setting and Design: Samples were
obtained from subjects who participated in a study based on the
WHO-designed MONICA (multinational monitoring of trends and
determinants in cardiovascular disease) study for coronary artery
disease risk assessment in Zone 17 of Tehran. The study was approved by
the local ethical committee. Informed consent was obtained from all
subjects included in this study. Materials and Methods: Subjects
(n=320) were recruited. The level of triglyceride (TG) and total serum
cholesterol was tested for all subjects in this study. Genotyping for
APOE was carried using polymerase chain reaction-Restriction fragment
length polymorphism (PCR-RFLP)technique. Statistical Analysis: Levels
of significance were determined using contingency tables by either
Chi-square or Fisher exact analysis using the STATA (v8) software. The
analysis of regression and significance of differences for level of
cholesterol and TG was established by one-way analysis of variance
followed by Dunnett post hoc multiple comparison tests using SPSS
software Version 11.5. Results: The frequency of allele E2 was
significantly higher in patients with total serum cholesterol level
<200 mg/dl (P 0.01 OR 2.1 95% CI 1.1-4.2). Conclusion: The
association found in this study between allele E2 and lower total
cholesterol level had been reported in previous studies. We have also
observed that the frequency of genotype E2/E3 and E2/E4 was
significantly higher in patients with normal total serum cholesterol
level compared to patients with abnormal cholesterol (P=0.003 OR 2.4
95% CI; 1.3-4.6). Our data needs to be repeated in a larger population
with more information for serum LDL and HDL levels and their subgroups.</description><subject>Adult</subject><subject>Alleles</subject><subject>Apolipoprotein, cholesterol, diabetes</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins E - genetics</subject><subject>Arabs - genetics</subject><subject>Blood cholesterol</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Confidence intervals</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Female</subject><subject>Genetic polymorphisms</subject><subject>Genotype</subject><subject>Humans</subject><subject>Hyperlipidemias - genetics</subject><subject>Identification and classification</subject><subject>Iran</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Measurement</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length - genetics</subject><subject>Properties</subject><subject>Regression analysis</subject><subject>Risk assessment</subject><subject>Triglycerides - blood</subject><issn>0022-3859</issn><issn>0972-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkc1rHCEYxqWkNB_tObcg6Xk2fo2OxyWkTSDQS3vpRRx1EhdHJzoTyH9ft5tNCCwKyuvveT98ADjHaMUwolcIEdLQrpUr3nEiP4ETJAVpSEfoUb3vX4_BaSkbhDDnjH4BxwQJKgVHJ-DvekrBT2nKaXY-whv44KKDNfgypjw9-jJCHS2c06wDLC4vIzSPKbgyu5wCDO7ZBViFd1lHr2NVTkvQs0_xK_g86FDct9fzDPz5cfP7-ra5__Xz7np93_Qt6uaGYYqspS0TzNLOYKyJlcNgjGFW9IOkUre9wMzoAUncCtp2hEuquaA9tRLRM3C5y1tneFpqY2qTlhxrSdXVCrglglXo-w560MEpH4c0Z21GX4xaE8oJlpLxSjUHqO2PZB1SdIOv4Q_86gBfl3WjNwcFVzuByamU7AY1ZT_q_KIwUltH1dYztfVM_Xe0Ki5ep1v60dk3fm_hew-9r05G90aY7LXaBzdT3Rgh1tF_EVOqgA</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Bazzaz, J. T</creator><creator>Nazari, M</creator><creator>Nazem, H</creator><creator>Amiri, P</creator><creator>Fakhrzadeh, H</creator><creator>Heshmat, R</creator><creator>Abbaszadeh, S</creator><creator>Amoli, M. M</creator><general>Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt. 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T ; Nazari, M ; Nazem, H ; Amiri, P ; Fakhrzadeh, H ; Heshmat, R ; Abbaszadeh, S ; Amoli, M. 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T</creatorcontrib><creatorcontrib>Nazari, M</creatorcontrib><creatorcontrib>Nazem, H</creatorcontrib><creatorcontrib>Amiri, P</creatorcontrib><creatorcontrib>Fakhrzadeh, H</creatorcontrib><creatorcontrib>Heshmat, R</creatorcontrib><creatorcontrib>Abbaszadeh, S</creatorcontrib><creatorcontrib>Amoli, M. 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T</au><au>Nazari, M</au><au>Nazem, H</au><au>Amiri, P</au><au>Fakhrzadeh, H</au><au>Heshmat, R</au><au>Abbaszadeh, S</au><au>Amoli, M. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population</atitle><jtitle>Journal of postgraduate medicine</jtitle><addtitle>J Postgrad Med</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>56</volume><issue>3</issue><spage>173</spage><epage>175</epage><pages>173-175</pages><issn>0022-3859</issn><eissn>0972-2823</eissn><abstract>Background: Apolipoprotein E (APOE) is known as a major regulator of
blood lipid levels in humans. A number of APOE gene allelic variants
have been reported including E2, E3 and E4. Recent studies suggested a
role for APOE in obesity and increased Body Mass Index (BMI) and plasma
lipid levels in obese children. Aim: The aim of this study was to
examine the association between APOE genetic variants and the BMI and
lipid profile in an Iranian cohort. Setting and Design: Samples were
obtained from subjects who participated in a study based on the
WHO-designed MONICA (multinational monitoring of trends and
determinants in cardiovascular disease) study for coronary artery
disease risk assessment in Zone 17 of Tehran. The study was approved by
the local ethical committee. Informed consent was obtained from all
subjects included in this study. Materials and Methods: Subjects
(n=320) were recruited. The level of triglyceride (TG) and total serum
cholesterol was tested for all subjects in this study. Genotyping for
APOE was carried using polymerase chain reaction-Restriction fragment
length polymorphism (PCR-RFLP)technique. Statistical Analysis: Levels
of significance were determined using contingency tables by either
Chi-square or Fisher exact analysis using the STATA (v8) software. The
analysis of regression and significance of differences for level of
cholesterol and TG was established by one-way analysis of variance
followed by Dunnett post hoc multiple comparison tests using SPSS
software Version 11.5. Results: The frequency of allele E2 was
significantly higher in patients with total serum cholesterol level
<200 mg/dl (P 0.01 OR 2.1 95% CI 1.1-4.2). Conclusion: The
association found in this study between allele E2 and lower total
cholesterol level had been reported in previous studies. We have also
observed that the frequency of genotype E2/E3 and E2/E4 was
significantly higher in patients with normal total serum cholesterol
level compared to patients with abnormal cholesterol (P=0.003 OR 2.4
95% CI; 1.3-4.6). Our data needs to be repeated in a larger population
with more information for serum LDL and HDL levels and their subgroups.</abstract><cop>India</cop><pub>Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India</pub><pmid>20739760</pmid><doi>10.4103/0022-3859.68629</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3859 |
| ispartof | Journal of postgraduate medicine, 2010-07, Vol.56 (3), p.173-175 |
| issn | 0022-3859 0972-2823 |
| language | eng |
| recordid | cdi_proquest_journals_850815274 |
| source | MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Alleles Apolipoprotein, cholesterol, diabetes Apolipoproteins Apolipoproteins E - genetics Arabs - genetics Blood cholesterol Body Mass Index Cardiovascular disease Cholesterol Cholesterol - blood Confidence intervals Deoxyribonucleic acid DNA Female Genetic polymorphisms Genotype Humans Hyperlipidemias - genetics Identification and classification Iran Lipids Low density lipoprotein Male Measurement Middle Aged Polymerase Chain Reaction Polymorphism, Restriction Fragment Length - genetics Properties Regression analysis Risk assessment Triglycerides - blood |
| title | Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population |
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