High-Transmission-Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally Invasive Tumor Margin Detection
The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with "side-viewing"...
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| Veröffentlicht in: | IEEE sensors journal 2011-04, Vol.11 (4), p.891-896 |
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| creator | Garcia-Uribe, A Cheng-Chung Chang Yapici, M K Jun Zou Banerjee, B Kuczynski, J Ong, E S Marner, E S Wang, L V |
| description | The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with "side-viewing" capability. Its unprecedented small size, unique "side-viewing" capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results. |
| doi_str_mv | 10.1109/JSEN.2010.2076279 |
| format | Article |
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In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with "side-viewing" capability. Its unprecedented small size, unique "side-viewing" capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.</description><identifier>ISSN: 1530-437X</identifier><identifier>EISSN: 1558-1748</identifier><identifier>DOI: 10.1109/JSEN.2010.2076279</identifier><identifier>PMID: 21479115</identifier><identifier>CODEN: ISJEAZ</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Collection ; Data collection ; Diffuse reflectance ; Diffusion ; Incidence ; microoptical probe ; oblique incidence ; Optical device fabrication ; Optical fibers ; Optical sensors ; pancreatic cancer ; Probes ; Reflectance ; Reflectivity ; Sensors ; spectroscopy ; Substrates ; tumor margin ; Tumors</subject><ispartof>IEEE sensors journal, 2011-04, Vol.11 (4), p.891-896</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Apr 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-31b14ffdbba58067dc1f226da5c7f5007b6740002be79557cca8f5844d95b48e3</citedby><cites>FETCH-LOGICAL-c478t-31b14ffdbba58067dc1f226da5c7f5007b6740002be79557cca8f5844d95b48e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/5585661$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>230,314,776,780,792,881,27901,27902,54733</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/5585661$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21479115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Uribe, A</creatorcontrib><creatorcontrib>Cheng-Chung Chang</creatorcontrib><creatorcontrib>Yapici, M K</creatorcontrib><creatorcontrib>Jun Zou</creatorcontrib><creatorcontrib>Banerjee, B</creatorcontrib><creatorcontrib>Kuczynski, J</creatorcontrib><creatorcontrib>Ong, E S</creatorcontrib><creatorcontrib>Marner, E S</creatorcontrib><creatorcontrib>Wang, L V</creatorcontrib><title>High-Transmission-Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally Invasive Tumor Margin Detection</title><title>IEEE sensors journal</title><addtitle>JSEN</addtitle><addtitle>IEEE Sens J</addtitle><description>The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. 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| subjects | Collection Data collection Diffuse reflectance Diffusion Incidence microoptical probe oblique incidence Optical device fabrication Optical fibers Optical sensors pancreatic cancer Probes Reflectance Reflectivity Sensors spectroscopy Substrates tumor margin Tumors |
| title | High-Transmission-Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally Invasive Tumor Margin Detection |
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