Modeling Effect of a [gamma]-Secretase Inhibitor on Amyloid-[beta] Dynamics Reveals Significant Role of an Amyloid Clearance Mechanism

Aggregation of the small peptide amyloid beta (Aβ) into oligomers and fibrils in the brain is believed to be a precursor to Alzheimer's disease. Aβ is produced via multiple proteolytic cleavages of amyloid precursor protein (APP), mediated by the enzymes β- and γ-secretase. In this study, we ex...

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Veröffentlicht in:	Bulletin of mathematical biology 2011-01, Vol.73 (1), p.230
Hauptverfasser:	Das, Raibatak, Nachbar, Robert B, Edelstein-keshet, Leah, Saltzman, Jeffrey S, Wiener, Matthew C, Bagchi, Ansuman, Bailey, James, Coombs, Daniel, Simon, Adam J, Hargreaves, Richard J, Cook, Jacquelynn J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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