Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy
The purpose of the study is to highlight oncocytic modifications in rectal adenocarcinomas and evaluate a possible correlation with preoperative radiochemotherapy (RCT). Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200-225 mg/m(2)) and 44-46 Gy in 22-23...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2006-04, Vol.448 (4), p.442-448 |
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| creator | AMBROSINI-SPALTRO, Andrea SALVI, Fabrizio BETTS, Christine M FREZZA, Giovanni P PIEMONTESE, Antonio DEL PRETE, Pietro BALDONI, Cristina FOSCHINI, Maria P VIALE, Giuseppe |
| description | The purpose of the study is to highlight oncocytic modifications in rectal adenocarcinomas and evaluate a possible correlation with preoperative radiochemotherapy (RCT). Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200-225 mg/m(2)) and 44-46 Gy in 22-23 fractions, were studied. All patients underwent biopsy before RCT. Surgery was performed within 6 weeks after RCT. In all cases oncocytic modifications were searched for on hematoxylin and eosin (H&E) and at immunohistochemistry using an antimitochondrial antibody. In addition, in two cases, both pre- and post-RCT tissues were examined at electron microscopy. All tumors were adenocarcinomas. In pre-RCT biopsies, oncocytic changes were difficult to find on H&E, while the antimitochondrial antibody strongly stained numerous neoplastic cells (mean 48.4%). In post-RCT surgical specimens, oncocytic changes were detected in 24 out of 28 cases on H&E and the antimitochondrial antibody stained most of the residual neoplastic cells (mean 76.7%). Ultrastructural examination revealed large and bizarre mitochondria inside tumor cells both in pre- and post-RCT tissues. In conclusion, the present data suggest that rectal adenocarcinomas are "mitochondrion-rich" tumors. After preoperative RCT, residual neoplastic cells acquire a definite oncocytic phenotype. |
| doi_str_mv | 10.1007/s00428-005-0137-6 |
| format | Article |
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Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200-225 mg/m(2)) and 44-46 Gy in 22-23 fractions, were studied. All patients underwent biopsy before RCT. Surgery was performed within 6 weeks after RCT. In all cases oncocytic modifications were searched for on hematoxylin and eosin (H&E) and at immunohistochemistry using an antimitochondrial antibody. In addition, in two cases, both pre- and post-RCT tissues were examined at electron microscopy. All tumors were adenocarcinomas. In pre-RCT biopsies, oncocytic changes were difficult to find on H&E, while the antimitochondrial antibody strongly stained numerous neoplastic cells (mean 48.4%). In post-RCT surgical specimens, oncocytic changes were detected in 24 out of 28 cases on H&E and the antimitochondrial antibody stained most of the residual neoplastic cells (mean 76.7%). Ultrastructural examination revealed large and bizarre mitochondria inside tumor cells both in pre- and post-RCT tissues. In conclusion, the present data suggest that rectal adenocarcinomas are "mitochondrion-rich" tumors. After preoperative RCT, residual neoplastic cells acquire a definite oncocytic phenotype.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-005-0137-6</identifier><identifier>PMID: 16365727</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adenocarcinoma - drug therapy ; Adenocarcinoma - pathology ; Adenocarcinoma - radiotherapy ; Aged ; Antimetabolites, Antineoplastic - therapeutic use ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Cell Transformation, Neoplastic ; Cytoplasm - ultrastructure ; Female ; Fluorouracil - therapeutic use ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Liver cirrhosis ; Male ; Medical sciences ; Neoplasm, Residual - pathology ; Oxyphil Cells - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Radiotherapy, Adjuvant ; Rectal Neoplasms - drug therapy ; Rectal Neoplasms - pathology ; Rectal Neoplasms - radiotherapy ; Tumors</subject><ispartof>Virchows Archiv : an international journal of pathology, 2006-04, Vol.448 (4), p.442-448</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ea79b1bfa55d2eb5882daf19489b81b7223cb194b464de264e73c908b121baca3</citedby><cites>FETCH-LOGICAL-c356t-ea79b1bfa55d2eb5882daf19489b81b7223cb194b464de264e73c908b121baca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17704563$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16365727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AMBROSINI-SPALTRO, Andrea</creatorcontrib><creatorcontrib>SALVI, Fabrizio</creatorcontrib><creatorcontrib>BETTS, Christine M</creatorcontrib><creatorcontrib>FREZZA, Giovanni P</creatorcontrib><creatorcontrib>PIEMONTESE, Antonio</creatorcontrib><creatorcontrib>DEL PRETE, Pietro</creatorcontrib><creatorcontrib>BALDONI, Cristina</creatorcontrib><creatorcontrib>FOSCHINI, Maria P</creatorcontrib><creatorcontrib>VIALE, Giuseppe</creatorcontrib><title>Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><description>The purpose of the study is to highlight oncocytic modifications in rectal adenocarcinomas and evaluate a possible correlation with preoperative radiochemotherapy (RCT). Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200-225 mg/m(2)) and 44-46 Gy in 22-23 fractions, were studied. All patients underwent biopsy before RCT. Surgery was performed within 6 weeks after RCT. In all cases oncocytic modifications were searched for on hematoxylin and eosin (H&E) and at immunohistochemistry using an antimitochondrial antibody. In addition, in two cases, both pre- and post-RCT tissues were examined at electron microscopy. All tumors were adenocarcinomas. In pre-RCT biopsies, oncocytic changes were difficult to find on H&E, while the antimitochondrial antibody strongly stained numerous neoplastic cells (mean 48.4%). In post-RCT surgical specimens, oncocytic changes were detected in 24 out of 28 cases on H&E and the antimitochondrial antibody stained most of the residual neoplastic cells (mean 76.7%). Ultrastructural examination revealed large and bizarre mitochondria inside tumor cells both in pre- and post-RCT tissues. In conclusion, the present data suggest that rectal adenocarcinomas are "mitochondrion-rich" tumors. After preoperative RCT, residual neoplastic cells acquire a definite oncocytic phenotype.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - radiotherapy</subject><subject>Aged</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cytoplasm - ultrastructure</subject><subject>Female</subject><subject>Fluorouracil - therapeutic use</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver cirrhosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm, Residual - pathology</subject><subject>Oxyphil Cells - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Radiotherapy, Adjuvant</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AMBROSINI-SPALTRO, Andrea</creatorcontrib><creatorcontrib>SALVI, Fabrizio</creatorcontrib><creatorcontrib>BETTS, Christine M</creatorcontrib><creatorcontrib>FREZZA, Giovanni P</creatorcontrib><creatorcontrib>PIEMONTESE, Antonio</creatorcontrib><creatorcontrib>DEL PRETE, Pietro</creatorcontrib><creatorcontrib>BALDONI, Cristina</creatorcontrib><creatorcontrib>FOSCHINI, Maria P</creatorcontrib><creatorcontrib>VIALE, Giuseppe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AMBROSINI-SPALTRO, Andrea</au><au>SALVI, Fabrizio</au><au>BETTS, Christine M</au><au>FREZZA, Giovanni P</au><au>PIEMONTESE, Antonio</au><au>DEL PRETE, Pietro</au><au>BALDONI, Cristina</au><au>FOSCHINI, Maria P</au><au>VIALE, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><addtitle>Virchows Arch</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>448</volume><issue>4</issue><spage>442</spage><epage>448</epage><pages>442-448</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>The purpose of the study is to highlight oncocytic modifications in rectal adenocarcinomas and evaluate a possible correlation with preoperative radiochemotherapy (RCT). Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200-225 mg/m(2)) and 44-46 Gy in 22-23 fractions, were studied. All patients underwent biopsy before RCT. Surgery was performed within 6 weeks after RCT. In all cases oncocytic modifications were searched for on hematoxylin and eosin (H&E) and at immunohistochemistry using an antimitochondrial antibody. In addition, in two cases, both pre- and post-RCT tissues were examined at electron microscopy. All tumors were adenocarcinomas. In pre-RCT biopsies, oncocytic changes were difficult to find on H&E, while the antimitochondrial antibody strongly stained numerous neoplastic cells (mean 48.4%). In post-RCT surgical specimens, oncocytic changes were detected in 24 out of 28 cases on H&E and the antimitochondrial antibody stained most of the residual neoplastic cells (mean 76.7%). Ultrastructural examination revealed large and bizarre mitochondria inside tumor cells both in pre- and post-RCT tissues. In conclusion, the present data suggest that rectal adenocarcinomas are "mitochondrion-rich" tumors. After preoperative RCT, residual neoplastic cells acquire a definite oncocytic phenotype.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16365727</pmid><doi>10.1007/s00428-005-0137-6</doi><tpages>7</tpages></addata></record> |
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| ispartof | Virchows Archiv : an international journal of pathology, 2006-04, Vol.448 (4), p.442-448 |
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| subjects | Adenocarcinoma - drug therapy Adenocarcinoma - pathology Adenocarcinoma - radiotherapy Aged Antimetabolites, Antineoplastic - therapeutic use Biological and medical sciences Biomarkers, Tumor - analysis Cell Transformation, Neoplastic Cytoplasm - ultrastructure Female Fluorouracil - therapeutic use Humans Investigative techniques, diagnostic techniques (general aspects) Liver cirrhosis Male Medical sciences Neoplasm, Residual - pathology Oxyphil Cells - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Radiotherapy, Adjuvant Rectal Neoplasms - drug therapy Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Tumors |
| title | Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy |
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