Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice

Permanent scars form upon healing of tissue injuries such as those caused by ischemia (myocardial infarction, stroke), trauma, surgery, and inflammation. Current options in reducing scar formation are limited to local intervention. We have designed a systemically administered, target-seeking biother...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-12, Vol.107 (50), p.21671-21676
Hauptverfasser:	Järvinen, Tero A. H., Ruoslahti, Erkki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiogenesis Animals Automobiles Biological Sciences Blood Vessels - metabolism CHO Cells Cicatrix - drug therapy Cicatrix - pathology Cricetinae Cricetulus Decorin - genetics Decorin - pharmacology Decorin - therapeutic use Fibroblasts Fibrosis - pathology Granulation tissue Homing Humans Mice Molecular Sequence Data Molecules Neovascularization, Physiologic Pathology Peptides Peptides - genetics Peptides - pharmacology Peptides - therapeutic use Physical trauma Proteins Proteoglycans Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacology Recombinant Fusion Proteins - therapeutic use Rodents Scars Skin Transforming Growth Factor beta1 - metabolism Wound healing Wound Healing - drug effects
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