Tim-3 expression on PD-1^sup +^ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

Having successfully developed mechanisms to evade immune clearance, hepatitis C virus (HCV) establishes persistent infection in approximately 75%-80% of patients. In these individuals, the function of HCV-specific CD8+ T cells is impaired by ligation of inhibitory receptors, the repertoire of which...

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Veröffentlicht in:	The Journal of clinical investigation 2010-12, Vol.120 (12), p.4546
Hauptverfasser:	McMahan, Rachel H, Golden-Mason, Lucy, Nishimura, Michael I, McMahon, Brian J, Kemper, Michael, Allen, Todd M, Gretch, David R, Rosen, Hugo R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research
Online-Zugang:	Volltext
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