Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana
Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2010-12, Vol.107 (49), p.21199-21204 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 21204 |
|---|---|
| container_issue | 49 |
| container_start_page | 21199 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 107 |
| creator | Li, Yan Huang, Yu Bergelson, Joy Nordborg, Magnus Borevitz, Justin O. Chory, Joanne |
| description | Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of 473 unique accessions, with >12,000 plants across two seasonal plantings in each of two simulated local climates, Spain and Sweden. Genome-wide association mapping was carried out with 213,497 SNPs. A total of 12 FT candidate quantitative trait loci (QTL) were fine-mapped in two independent studies, including 4 located within ±10 kb of previously cloned FT alleles and 8 novel loci. All QTL show sensitivity to planting season and/or simulated location in a multi-QTL mixed model. Alleles at four QTL were significantly correlated with latitude of origin, implying past selection for faster flowering in southern locations. Finally, maximum seed yield was observed at an optimal FT unique to each season and location, with four FT QTL directly controlling yield. Our results suggest that these major, environmentally sensitive FT QTL play an important role in spatial and temporal adaptation. |
| doi_str_mv | 10.1073/pnas.1007431107 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_journals_817163892</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>25756855</jstor_id><sourcerecordid>25756855</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-1fd6e80ab82ee37f9ff2f64a3203effd3a908d03fe1688529cf71c1a517a4be13</originalsourceid><addsrcrecordid>eNqN0blvFDEUB2ALgcgSqKlAIxqqIT7GV4O0irikSDTQYr312IlXs_bE9kTKf4-XXbJAReXr80_Pfgi9JPgdwZJdzBFKm2E5MNI2HqEVwZr0YtD4MVphTGWvBjqcoWelbDHGmiv8FJ3RZpWWeIV-rEtJNkANKXY7mOcQr7vkuylZmDo7hR1U1xcXS6jhznW3C8QaKvxa1Ayh7mnoQuzWGTZhTHMJpas3MAWI8Bw98TAV9-I4nqPvHz98u_zcX3399OVyfdXbQavaEz8KpzBsFHWOSa-9p14MwChmzvuRgcZqxMw7IpTiVFsviSXAiYRh4wg7R-8PufOy2bnRuthqm8ycW_353iQI5u-TGG7MdbozrH0KFaoFvD0G5HS7uFLNLhTrpgmiS0sxigspJNX_IYmQmhHJm3zzj9ymJcf2Dw1JIpjStKGLA7I5lZKdfyiaYLPvsdn32Jx63G68_vOtD_53UxvojmB_8xQnzaCbIlo38upAtqWmfIrgkgvFOfsJghe43A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>817163892</pqid></control><display><type>article</type><title>Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Li, Yan ; Huang, Yu ; Bergelson, Joy ; Nordborg, Magnus ; Borevitz, Justin O. ; Chory, Joanne</creator><creatorcontrib>Li, Yan ; Huang, Yu ; Bergelson, Joy ; Nordborg, Magnus ; Borevitz, Justin O. ; Chory, Joanne</creatorcontrib><description>Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of 473 unique accessions, with >12,000 plants across two seasonal plantings in each of two simulated local climates, Spain and Sweden. Genome-wide association mapping was carried out with 213,497 SNPs. A total of 12 FT candidate quantitative trait loci (QTL) were fine-mapped in two independent studies, including 4 located within ±10 kb of previously cloned FT alleles and 8 novel loci. All QTL show sensitivity to planting season and/or simulated location in a multi-QTL mixed model. Alleles at four QTL were significantly correlated with latitude of origin, implying past selection for faster flowering in southern locations. Finally, maximum seed yield was observed at an optimal FT unique to each season and location, with four FT QTL directly controlling yield. Our results suggest that these major, environmentally sensitive FT QTL play an important role in spatial and temporal adaptation.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1007431107</identifier><identifier>PMID: 21078970</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Acclimatization - genetics ; Adaptations ; Alleles ; Arabidopsis - genetics ; Arabidopsis thaliana ; Biological Sciences ; Chromosome Mapping ; Climate ; Flowering ; Flowers & plants ; Flowers - genetics ; Gene loci ; Gene mapping ; Genes ; Genetic loci ; Genetic variation ; Genome-Wide Association Study ; Genomics ; Germination ; Planting seasons ; Plants ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Seasons ; Seeds ; Simulation ; Single-nucleotide polymorphism ; Spain ; Spring ; Studies ; Summer ; Sweden ; Vegetation mapping</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2010-12, Vol.107 (49), p.21199-21204</ispartof><rights>Copyright National Academy of Sciences Dec 7, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-1fd6e80ab82ee37f9ff2f64a3203effd3a908d03fe1688529cf71c1a517a4be13</citedby><cites>FETCH-LOGICAL-c498t-1fd6e80ab82ee37f9ff2f64a3203effd3a908d03fe1688529cf71c1a517a4be13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/107/49.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25756855$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25756855$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,729,782,786,805,887,27933,27934,53800,53802,58026,58259</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21078970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Huang, Yu</creatorcontrib><creatorcontrib>Bergelson, Joy</creatorcontrib><creatorcontrib>Nordborg, Magnus</creatorcontrib><creatorcontrib>Borevitz, Justin O.</creatorcontrib><creatorcontrib>Chory, Joanne</creatorcontrib><title>Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of 473 unique accessions, with >12,000 plants across two seasonal plantings in each of two simulated local climates, Spain and Sweden. Genome-wide association mapping was carried out with 213,497 SNPs. A total of 12 FT candidate quantitative trait loci (QTL) were fine-mapped in two independent studies, including 4 located within ±10 kb of previously cloned FT alleles and 8 novel loci. All QTL show sensitivity to planting season and/or simulated location in a multi-QTL mixed model. Alleles at four QTL were significantly correlated with latitude of origin, implying past selection for faster flowering in southern locations. Finally, maximum seed yield was observed at an optimal FT unique to each season and location, with four FT QTL directly controlling yield. Our results suggest that these major, environmentally sensitive FT QTL play an important role in spatial and temporal adaptation.</description><subject>Acclimatization - genetics</subject><subject>Adaptations</subject><subject>Alleles</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis thaliana</subject><subject>Biological Sciences</subject><subject>Chromosome Mapping</subject><subject>Climate</subject><subject>Flowering</subject><subject>Flowers & plants</subject><subject>Flowers - genetics</subject><subject>Gene loci</subject><subject>Gene mapping</subject><subject>Genes</subject><subject>Genetic loci</subject><subject>Genetic variation</subject><subject>Genome-Wide Association Study</subject><subject>Genomics</subject><subject>Germination</subject><subject>Planting seasons</subject><subject>Plants</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quantitative Trait Loci</subject><subject>Seasons</subject><subject>Seeds</subject><subject>Simulation</subject><subject>Single-nucleotide polymorphism</subject><subject>Spain</subject><subject>Spring</subject><subject>Studies</subject><subject>Summer</subject><subject>Sweden</subject><subject>Vegetation mapping</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0blvFDEUB2ALgcgSqKlAIxqqIT7GV4O0irikSDTQYr312IlXs_bE9kTKf4-XXbJAReXr80_Pfgi9JPgdwZJdzBFKm2E5MNI2HqEVwZr0YtD4MVphTGWvBjqcoWelbDHGmiv8FJ3RZpWWeIV-rEtJNkANKXY7mOcQr7vkuylZmDo7hR1U1xcXS6jhznW3C8QaKvxa1Ayh7mnoQuzWGTZhTHMJpas3MAWI8Bw98TAV9-I4nqPvHz98u_zcX3399OVyfdXbQavaEz8KpzBsFHWOSa-9p14MwChmzvuRgcZqxMw7IpTiVFsviSXAiYRh4wg7R-8PufOy2bnRuthqm8ycW_353iQI5u-TGG7MdbozrH0KFaoFvD0G5HS7uFLNLhTrpgmiS0sxigspJNX_IYmQmhHJm3zzj9ymJcf2Dw1JIpjStKGLA7I5lZKdfyiaYLPvsdn32Jx63G68_vOtD_53UxvojmB_8xQnzaCbIlo38upAtqWmfIrgkgvFOfsJghe43A</recordid><startdate>20101207</startdate><enddate>20101207</enddate><creator>Li, Yan</creator><creator>Huang, Yu</creator><creator>Bergelson, Joy</creator><creator>Nordborg, Magnus</creator><creator>Borevitz, Justin O.</creator><creator>Chory, Joanne</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101207</creationdate><title>Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana</title><author>Li, Yan ; Huang, Yu ; Bergelson, Joy ; Nordborg, Magnus ; Borevitz, Justin O. ; Chory, Joanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-1fd6e80ab82ee37f9ff2f64a3203effd3a908d03fe1688529cf71c1a517a4be13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acclimatization - genetics</topic><topic>Adaptations</topic><topic>Alleles</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis thaliana</topic><topic>Biological Sciences</topic><topic>Chromosome Mapping</topic><topic>Climate</topic><topic>Flowering</topic><topic>Flowers & plants</topic><topic>Flowers - genetics</topic><topic>Gene loci</topic><topic>Gene mapping</topic><topic>Genes</topic><topic>Genetic loci</topic><topic>Genetic variation</topic><topic>Genome-Wide Association Study</topic><topic>Genomics</topic><topic>Germination</topic><topic>Planting seasons</topic><topic>Plants</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Quantitative Trait Loci</topic><topic>Seasons</topic><topic>Seeds</topic><topic>Simulation</topic><topic>Single-nucleotide polymorphism</topic><topic>Spain</topic><topic>Spring</topic><topic>Studies</topic><topic>Summer</topic><topic>Sweden</topic><topic>Vegetation mapping</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Huang, Yu</creatorcontrib><creatorcontrib>Bergelson, Joy</creatorcontrib><creatorcontrib>Nordborg, Magnus</creatorcontrib><creatorcontrib>Borevitz, Justin O.</creatorcontrib><creatorcontrib>Chory, Joanne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yan</au><au>Huang, Yu</au><au>Bergelson, Joy</au><au>Nordborg, Magnus</au><au>Borevitz, Justin O.</au><au>Chory, Joanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2010-12-07</date><risdate>2010</risdate><volume>107</volume><issue>49</issue><spage>21199</spage><epage>21204</epage><pages>21199-21204</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of 473 unique accessions, with >12,000 plants across two seasonal plantings in each of two simulated local climates, Spain and Sweden. Genome-wide association mapping was carried out with 213,497 SNPs. A total of 12 FT candidate quantitative trait loci (QTL) were fine-mapped in two independent studies, including 4 located within ±10 kb of previously cloned FT alleles and 8 novel loci. All QTL show sensitivity to planting season and/or simulated location in a multi-QTL mixed model. Alleles at four QTL were significantly correlated with latitude of origin, implying past selection for faster flowering in southern locations. Finally, maximum seed yield was observed at an optimal FT unique to each season and location, with four FT QTL directly controlling yield. Our results suggest that these major, environmentally sensitive FT QTL play an important role in spatial and temporal adaptation.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>21078970</pmid><doi>10.1073/pnas.1007431107</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2010-12, Vol.107 (49), p.21199-21204 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_journals_817163892 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Acclimatization - genetics Adaptations Alleles Arabidopsis - genetics Arabidopsis thaliana Biological Sciences Chromosome Mapping Climate Flowering Flowers & plants Flowers - genetics Gene loci Gene mapping Genes Genetic loci Genetic variation Genome-Wide Association Study Genomics Germination Planting seasons Plants Polymorphism, Single Nucleotide Quantitative Trait Loci Seasons Seeds Simulation Single-nucleotide polymorphism Spain Spring Studies Summer Sweden Vegetation mapping |
| title | Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T17%3A38%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20mapping%20of%20local%20climate-sensitive%20quantitative%20trait%20loci%20in%20Arabidopsis%20thaliana&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Li,%20Yan&rft.date=2010-12-07&rft.volume=107&rft.issue=49&rft.spage=21199&rft.epage=21204&rft.pages=21199-21204&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.1007431107&rft_dat=%3Cjstor_proqu%3E25756855%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=817163892&rft_id=info:pmid/21078970&rft_jstor_id=25756855&rfr_iscdi=true |