pK^sub a^ Values for the Unfolded State under Native Conditions Explain the pH-Dependent Stability of PGB1

Understanding the role of electrostatics in protein stability requires knowledge of these interactions in both the folded and unfolded states. Electrostatic interactions can be probed experimentally by characterizing ionization equilibria of titrating groups, parameterized as ... values. However, .....

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Veröffentlicht in:	Biophysical journal 2010-11, Vol.99 (10), p.3365
Hauptverfasser:	Lindman, Stina, Bauer, Mikael C, Lund, Mikael, Diehl, Carl, Mulder, Frans AA, Akke, Mikael, Linse, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Monte Carlo simulation Normal distribution Protein folding Proteins
Online-Zugang:	Volltext
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