In Vivo Distribution of Polymeric Nanoparticles at the Whole-Body, Tumor, and Cellular Levels

Purpose Block copolymer micelles (BCMs) were functionalized with indium-111 and/or epidermal growth factor (EGF), which enabled investigation of the in vivo transport of passively and actively targeted BCMs. The integration of conventional and image-based techniques afforded novel quantitative means...

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Veröffentlicht in:	Pharmaceutical research 2010-11, Vol.27 (11), p.2343-2355
Hauptverfasser:	Lee, Helen, Hoang, Bryan, Fonge, Humphrey, Reilly, Raymond M, Allen, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	active targeting Animals Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine block copolymer micelles epidermal growth factor Female intratumoral distribution Kinetics Medical Law Mice Mice, Inbred BALB C Micelles Nanoparticles passive targeting Pharmacokinetics Pharmacology Pharmacology/Toxicology Pharmacy Polymers Research Paper Rodents Tomography, Emission-Computed, Single-Photon
Online-Zugang:	Volltext
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