Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model
Hydroxyapatite cement (BoneSource®) and brushite calcium phosphate cement (chronOS™ Inject) were tested for fixation of glass ceramic implants (Bioverit®) in experimentally created cranial defects in 24 adult New Zealand White rabbits. Aim of the in vivo study was to assess and compare the biocompat...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2010-10, Vol.21 (10), p.2853-2859 |
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| creator | Schneider, Gerlind Blechschmidt, Karin Linde, Dirk Litschko, Peter Körbs, Thomas Beleites, Eggert |
| description | Hydroxyapatite cement (BoneSource®) and brushite calcium phosphate cement (chronOS™ Inject) were tested for fixation of glass ceramic implants (Bioverit®) in experimentally created cranial defects in 24 adult New Zealand White rabbits. Aim of the in vivo study was to assess and compare the biocompatibility and osseointegration of the implanted materials. Macroscopic and histological evaluations were performed 1 month, 3 months, and 6 months postoperatively. All implanted materials were well tolerated by the surrounding tissue. Both bone cements exhibited osteoconductive properties. Differences could be detected regarding to the rates of cement resorption and new bone formation. The brushite cement was resorbed faster than the hydroxyapatite cement. The chronOS™ Inject samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration. BoneSource® was replaced by bone with minimal invasion of connective tissue. New bone formation occurred faster compared to the chronOS™ Inject group. Bioverit® implants fixed with BoneSource® were successfully osseointegrated. |
| doi_str_mv | 10.1007/s10856-010-4143-0 |
| format | Article |
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Aim of the in vivo study was to assess and compare the biocompatibility and osseointegration of the implanted materials. Macroscopic and histological evaluations were performed 1 month, 3 months, and 6 months postoperatively. All implanted materials were well tolerated by the surrounding tissue. Both bone cements exhibited osteoconductive properties. Differences could be detected regarding to the rates of cement resorption and new bone formation. The brushite cement was resorbed faster than the hydroxyapatite cement. The chronOS™ Inject samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration. BoneSource® was replaced by bone with minimal invasion of connective tissue. New bone formation occurred faster compared to the chronOS™ Inject group. Bioverit® implants fixed with BoneSource® were successfully osseointegrated.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-010-4143-0</identifier><identifier>PMID: 20859655</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adhesives ; Animals ; Biocompatible Materials ; Biological and medical sciences ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Bone Cements - chemistry ; Bone Regeneration ; Bone Substitutes - chemistry ; Calcium Phosphates - chemistry ; Ceramics ; Ceramics - chemistry ; Chemistry and Materials Science ; Composites ; Female ; Glass ; Glass - chemistry ; Hydroxyapatites ; Materials Science ; Materials Testing ; Medical sciences ; Models, Animal ; Natural Materials ; Orthopedic surgery ; Osseointegration ; Polymer Sciences ; Rabbits ; Regenerative Medicine/Tissue Engineering ; Skull - surgery ; Surfaces and Interfaces ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Thin Films</subject><ispartof>Journal of materials science. 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Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Hydroxyapatite cement (BoneSource®) and brushite calcium phosphate cement (chronOS™ Inject) were tested for fixation of glass ceramic implants (Bioverit®) in experimentally created cranial defects in 24 adult New Zealand White rabbits. Aim of the in vivo study was to assess and compare the biocompatibility and osseointegration of the implanted materials. Macroscopic and histological evaluations were performed 1 month, 3 months, and 6 months postoperatively. All implanted materials were well tolerated by the surrounding tissue. Both bone cements exhibited osteoconductive properties. Differences could be detected regarding to the rates of cement resorption and new bone formation. The brushite cement was resorbed faster than the hydroxyapatite cement. The chronOS™ Inject samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration. BoneSource® was replaced by bone with minimal invasion of connective tissue. New bone formation occurred faster compared to the chronOS™ Inject group. Bioverit® implants fixed with BoneSource® were successfully osseointegrated.</description><subject>Adhesives</subject><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Bone Cements - chemistry</subject><subject>Bone Regeneration</subject><subject>Bone Substitutes - chemistry</subject><subject>Calcium Phosphates - chemistry</subject><subject>Ceramics</subject><subject>Ceramics - chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Female</subject><subject>Glass</subject><subject>Glass - chemistry</subject><subject>Hydroxyapatites</subject><subject>Materials Science</subject><subject>Materials Testing</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Natural Materials</subject><subject>Orthopedic surgery</subject><subject>Osseointegration</subject><subject>Polymer Sciences</subject><subject>Rabbits</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Skull - surgery</subject><subject>Surfaces and Interfaces</subject><subject>Surgery (general aspects). 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, Gerlind</au><au>Blechschmidt, Karin</au><au>Linde, Dirk</au><au>Litschko, Peter</au><au>Körbs, Thomas</au><au>Beleites, Eggert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>21</volume><issue>10</issue><spage>2853</spage><epage>2859</epage><pages>2853-2859</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Hydroxyapatite cement (BoneSource®) and brushite calcium phosphate cement (chronOS™ Inject) were tested for fixation of glass ceramic implants (Bioverit®) in experimentally created cranial defects in 24 adult New Zealand White rabbits. Aim of the in vivo study was to assess and compare the biocompatibility and osseointegration of the implanted materials. Macroscopic and histological evaluations were performed 1 month, 3 months, and 6 months postoperatively. All implanted materials were well tolerated by the surrounding tissue. Both bone cements exhibited osteoconductive properties. Differences could be detected regarding to the rates of cement resorption and new bone formation. The brushite cement was resorbed faster than the hydroxyapatite cement. The chronOS™ Inject samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration. BoneSource® was replaced by bone with minimal invasion of connective tissue. New bone formation occurred faster compared to the chronOS™ Inject group. Bioverit® implants fixed with BoneSource® were successfully osseointegrated.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20859655</pmid><doi>10.1007/s10856-010-4143-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Adhesives Animals Biocompatible Materials Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bone Cements - chemistry Bone Regeneration Bone Substitutes - chemistry Calcium Phosphates - chemistry Ceramics Ceramics - chemistry Chemistry and Materials Science Composites Female Glass Glass - chemistry Hydroxyapatites Materials Science Materials Testing Medical sciences Models, Animal Natural Materials Orthopedic surgery Osseointegration Polymer Sciences Rabbits Regenerative Medicine/Tissue Engineering Skull - surgery Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films |
| title | Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model |
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