Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/[beta]-catenin antagonists against human osteosarcoma cells

Aberrant activation of the Wnt/β-catenin signaling pathway promotes osteosarcoma tumorigenesis and metastasis. In this study, we tested the hypothesis that osteosarcoma progression may be delayed by disrupting the Wnt/β-catenin pathway using small molecule inhibitors such as curcumin and PKF118-310....

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Veröffentlicht in:	Investigational new drugs 2010-12, Vol.28 (6), p.766
Hauptverfasser:	Leow, Pay-chin, Tian, Quan, Ong, Zhan-yuin, Yang, Zheng, Ee, Pui-lai Rachel
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bone cancer Cell adhesion & migration Cell cycle Proteins Wound healing
Online-Zugang:	Volltext
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