Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy
BACKGROUND: It has been reported that deviations in gut microbiota composition may predispose toward obesity, and specific groups of commensal gut bacteria may harvest energy from food more efficiently than others. Alterations in microbiota compositions of mothers may be transferred to infants and l...
Gespeichert in:
| Veröffentlicht in: | The American journal of clinical nutrition 2010-11, Vol.92 (5), p.1023-1030 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1030 |
|---|---|
| container_issue | 5 |
| container_start_page | 1023 |
| container_title | The American journal of clinical nutrition |
| container_volume | 92 |
| creator | Collado, Maria Carmen Isolauri, Erika Laitinen, Kirsi Salminen, Seppo |
| description | BACKGROUND: It has been reported that deviations in gut microbiota composition may predispose toward obesity, and specific groups of commensal gut bacteria may harvest energy from food more efficiently than others. Alterations in microbiota compositions of mothers may be transferred to infants and lead to an increased risk of overweight. OBJECTIVE: We analyzed the fecal microbiota composition of infants of overweight and normal-weight mothers and assessed the relations of weight and excessive weight gain of mothers during pregnancy on the microbiota of infants. DESIGN: Mothers (n = 16) whose prepregnancy body mass index (BMI; in kg/m²) was ≥25 were selected with their infants from a prospective follow-up study of 256 women. Women with a BMI |
| doi_str_mv | 10.3945/ajcn.2010.29877 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_801740162</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2191282781</sourcerecordid><originalsourceid>FETCH-LOGICAL-a475t-964cb5b3ebddab224bfea2a2e9166423f9f778ffe865bcdc8d42531cd2f19123</originalsourceid><addsrcrecordid>eNpFkcluFDEQhi0EIpPAmRtYSBEXOvHWGzcUhUWKxIFwttxeJh512x3bnWjeiMekmpmAfLCr_NVfLv8IvaHkgveivlQ7HS4YgZD1Xds-Qxva867ijLTP0YYQwqqeNvUJOs15RwhlomteohNGOiFIU2_Q72vnrC44OjzFcmfTh4wfrd_eQSpgH5wKBVKT1ykOPhaFlb5ffPbFx_AR6zjN8SlQwcBt8Q--7LFZkg9bbFUa9wcdvf-EFZ5TzLNdKYtdHMf4WC0zzmUxKwZKqlgDp2PlnOw2rLWv0AunxmxfH_czdPvl-vbqW3Xz4-v3q883lRJtXaq-EXqoB24HY9TAmBicVUwxC9_QCMZd79q2g5m7ph600Z0RrOZUG-ZoTxk_Q-8PsvDO-8XmIndxSQE6yo7QVhDarNDlAYJPyTlZJ-fkJ5X2khK5-iJXX-Tqi_zrC1S8Pcouw2TNP_7JCADOj4DKWo0uwcw-_-c472Bx4N4dOKeiVNsEzK-f0IgT2hNaw4R_AKaQo-k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>801740162</pqid></control><display><type>article</type><title>Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Collado, Maria Carmen ; Isolauri, Erika ; Laitinen, Kirsi ; Salminen, Seppo</creator><creatorcontrib>Collado, Maria Carmen ; Isolauri, Erika ; Laitinen, Kirsi ; Salminen, Seppo</creatorcontrib><description>BACKGROUND: It has been reported that deviations in gut microbiota composition may predispose toward obesity, and specific groups of commensal gut bacteria may harvest energy from food more efficiently than others. Alterations in microbiota compositions of mothers may be transferred to infants and lead to an increased risk of overweight. OBJECTIVE: We analyzed the fecal microbiota composition of infants of overweight and normal-weight mothers and assessed the relations of weight and excessive weight gain of mothers during pregnancy on the microbiota of infants. DESIGN: Mothers (n = 16) whose prepregnancy body mass index (BMI; in kg/m²) was ≥25 were selected with their infants from a prospective follow-up study of 256 women. Women with a BMI <25 (n = 26) and their infants served as control subjects. At the ages of 1 and 6 mo, infant stool samples were available for the analysis of microbiota composition by fluorescence in situ hybridization combined with flow cytometry and quantitative real-time polymerase chain reaction. RESULTS: Infants' fecal microbial composition was related to the weight and weight gain of their mothers during pregnancy. Fecal Bacteroides and Staphylococcus concentrations were significantly higher in infants of overweight mothers during the first 6 mo. Higher weights and BMIs of mothers were related to higher concentrations of Bacteroides, Clostridium, and Staphylococcus and lower concentrations of the Bifidobacterium group. Prevalences of Akkermansia muciniphila, Staphylococcus, and Clostridium difficile groups were lower in infants of normal-weight mothers and of mothers with normal weight gains during pregnancy. CONCLUSION: The composition and development of infant gut microbiota are influenced by BMI, weight, and weight gain of mothers during pregnancy.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.2010.29877</identifier><identifier>PMID: 20844065</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Adult ; Akkermansia muciniphila ; Babies ; Bacteria - classification ; Bacteria - genetics ; Bacteria - growth & development ; Bacteroides ; Bifidobacterium ; Biological and medical sciences ; Body Mass Index ; Clostridium ; Clostridium difficile ; Colony Count, Microbial ; Feces - microbiology ; Feeding. Feeding behavior ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Tract - microbiology ; Humans ; Impact analysis ; Infant, Newborn - physiology ; infants ; intestinal microorganisms ; maternal nutrition ; microbial activity ; microbial colonization ; Mothers ; Nutrition ; nutritional status ; Obesity ; Overweight ; Pregnancy ; Pregnancy - physiology ; pregnant women ; prevalence ; Prospective Studies ; Reference Values ; Reverse Transcriptase Polymerase Chain Reaction ; Staphylococcus ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weight ; Weight Gain</subject><ispartof>The American journal of clinical nutrition, 2010-11, Vol.92 (5), p.1023-1030</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Nov 1, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a475t-964cb5b3ebddab224bfea2a2e9166423f9f778ffe865bcdc8d42531cd2f19123</citedby><cites>FETCH-LOGICAL-a475t-964cb5b3ebddab224bfea2a2e9166423f9f778ffe865bcdc8d42531cd2f19123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23383833$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20844065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Collado, Maria Carmen</creatorcontrib><creatorcontrib>Isolauri, Erika</creatorcontrib><creatorcontrib>Laitinen, Kirsi</creatorcontrib><creatorcontrib>Salminen, Seppo</creatorcontrib><title>Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>BACKGROUND: It has been reported that deviations in gut microbiota composition may predispose toward obesity, and specific groups of commensal gut bacteria may harvest energy from food more efficiently than others. Alterations in microbiota compositions of mothers may be transferred to infants and lead to an increased risk of overweight. OBJECTIVE: We analyzed the fecal microbiota composition of infants of overweight and normal-weight mothers and assessed the relations of weight and excessive weight gain of mothers during pregnancy on the microbiota of infants. DESIGN: Mothers (n = 16) whose prepregnancy body mass index (BMI; in kg/m²) was ≥25 were selected with their infants from a prospective follow-up study of 256 women. Women with a BMI <25 (n = 26) and their infants served as control subjects. At the ages of 1 and 6 mo, infant stool samples were available for the analysis of microbiota composition by fluorescence in situ hybridization combined with flow cytometry and quantitative real-time polymerase chain reaction. RESULTS: Infants' fecal microbial composition was related to the weight and weight gain of their mothers during pregnancy. Fecal Bacteroides and Staphylococcus concentrations were significantly higher in infants of overweight mothers during the first 6 mo. Higher weights and BMIs of mothers were related to higher concentrations of Bacteroides, Clostridium, and Staphylococcus and lower concentrations of the Bifidobacterium group. Prevalences of Akkermansia muciniphila, Staphylococcus, and Clostridium difficile groups were lower in infants of normal-weight mothers and of mothers with normal weight gains during pregnancy. CONCLUSION: The composition and development of infant gut microbiota are influenced by BMI, weight, and weight gain of mothers during pregnancy.</description><subject>Adult</subject><subject>Akkermansia muciniphila</subject><subject>Babies</subject><subject>Bacteria - classification</subject><subject>Bacteria - genetics</subject><subject>Bacteria - growth & development</subject><subject>Bacteroides</subject><subject>Bifidobacterium</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Clostridium</subject><subject>Clostridium difficile</subject><subject>Colony Count, Microbial</subject><subject>Feces - microbiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Humans</subject><subject>Impact analysis</subject><subject>Infant, Newborn - physiology</subject><subject>infants</subject><subject>intestinal microorganisms</subject><subject>maternal nutrition</subject><subject>microbial activity</subject><subject>microbial colonization</subject><subject>Mothers</subject><subject>Nutrition</subject><subject>nutritional status</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Pregnancy</subject><subject>Pregnancy - physiology</subject><subject>pregnant women</subject><subject>prevalence</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Staphylococcus</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Weight</subject><subject>Weight Gain</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkcluFDEQhi0EIpPAmRtYSBEXOvHWGzcUhUWKxIFwttxeJh512x3bnWjeiMekmpmAfLCr_NVfLv8IvaHkgveivlQ7HS4YgZD1Xds-Qxva867ijLTP0YYQwqqeNvUJOs15RwhlomteohNGOiFIU2_Q72vnrC44OjzFcmfTh4wfrd_eQSpgH5wKBVKT1ykOPhaFlb5ffPbFx_AR6zjN8SlQwcBt8Q--7LFZkg9bbFUa9wcdvf-EFZ5TzLNdKYtdHMf4WC0zzmUxKwZKqlgDp2PlnOw2rLWv0AunxmxfH_czdPvl-vbqW3Xz4-v3q883lRJtXaq-EXqoB24HY9TAmBicVUwxC9_QCMZd79q2g5m7ph600Z0RrOZUG-ZoTxk_Q-8PsvDO-8XmIndxSQE6yo7QVhDarNDlAYJPyTlZJ-fkJ5X2khK5-iJXX-Tqi_zrC1S8Pcouw2TNP_7JCADOj4DKWo0uwcw-_-c472Bx4N4dOKeiVNsEzK-f0IgT2hNaw4R_AKaQo-k</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Collado, Maria Carmen</creator><creator>Isolauri, Erika</creator><creator>Laitinen, Kirsi</creator><creator>Salminen, Seppo</creator><general>American Society for Clinical Nutrition</general><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>20101101</creationdate><title>Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy</title><author>Collado, Maria Carmen ; Isolauri, Erika ; Laitinen, Kirsi ; Salminen, Seppo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a475t-964cb5b3ebddab224bfea2a2e9166423f9f778ffe865bcdc8d42531cd2f19123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Akkermansia muciniphila</topic><topic>Babies</topic><topic>Bacteria - classification</topic><topic>Bacteria - genetics</topic><topic>Bacteria - growth & development</topic><topic>Bacteroides</topic><topic>Bifidobacterium</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Clostridium</topic><topic>Clostridium difficile</topic><topic>Colony Count, Microbial</topic><topic>Feces - microbiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Tract - microbiology</topic><topic>Humans</topic><topic>Impact analysis</topic><topic>Infant, Newborn - physiology</topic><topic>infants</topic><topic>intestinal microorganisms</topic><topic>maternal nutrition</topic><topic>microbial activity</topic><topic>microbial colonization</topic><topic>Mothers</topic><topic>Nutrition</topic><topic>nutritional status</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Pregnancy</topic><topic>Pregnancy - physiology</topic><topic>pregnant women</topic><topic>prevalence</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Staphylococcus</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Weight</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collado, Maria Carmen</creatorcontrib><creatorcontrib>Isolauri, Erika</creatorcontrib><creatorcontrib>Laitinen, Kirsi</creatorcontrib><creatorcontrib>Salminen, Seppo</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collado, Maria Carmen</au><au>Isolauri, Erika</au><au>Laitinen, Kirsi</au><au>Salminen, Seppo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>92</volume><issue>5</issue><spage>1023</spage><epage>1030</epage><pages>1023-1030</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>BACKGROUND: It has been reported that deviations in gut microbiota composition may predispose toward obesity, and specific groups of commensal gut bacteria may harvest energy from food more efficiently than others. Alterations in microbiota compositions of mothers may be transferred to infants and lead to an increased risk of overweight. OBJECTIVE: We analyzed the fecal microbiota composition of infants of overweight and normal-weight mothers and assessed the relations of weight and excessive weight gain of mothers during pregnancy on the microbiota of infants. DESIGN: Mothers (n = 16) whose prepregnancy body mass index (BMI; in kg/m²) was ≥25 were selected with their infants from a prospective follow-up study of 256 women. Women with a BMI <25 (n = 26) and their infants served as control subjects. At the ages of 1 and 6 mo, infant stool samples were available for the analysis of microbiota composition by fluorescence in situ hybridization combined with flow cytometry and quantitative real-time polymerase chain reaction. RESULTS: Infants' fecal microbial composition was related to the weight and weight gain of their mothers during pregnancy. Fecal Bacteroides and Staphylococcus concentrations were significantly higher in infants of overweight mothers during the first 6 mo. Higher weights and BMIs of mothers were related to higher concentrations of Bacteroides, Clostridium, and Staphylococcus and lower concentrations of the Bifidobacterium group. Prevalences of Akkermansia muciniphila, Staphylococcus, and Clostridium difficile groups were lower in infants of normal-weight mothers and of mothers with normal weight gains during pregnancy. CONCLUSION: The composition and development of infant gut microbiota are influenced by BMI, weight, and weight gain of mothers during pregnancy.</abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>20844065</pmid><doi>10.3945/ajcn.2010.29877</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 2010-11, Vol.92 (5), p.1023-1030 |
| issn | 0002-9165 1938-3207 |
| language | eng |
| recordid | cdi_proquest_journals_801740162 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Akkermansia muciniphila Babies Bacteria - classification Bacteria - genetics Bacteria - growth & development Bacteroides Bifidobacterium Biological and medical sciences Body Mass Index Clostridium Clostridium difficile Colony Count, Microbial Feces - microbiology Feeding. Feeding behavior Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - microbiology Humans Impact analysis Infant, Newborn - physiology infants intestinal microorganisms maternal nutrition microbial activity microbial colonization Mothers Nutrition nutritional status Obesity Overweight Pregnancy Pregnancy - physiology pregnant women prevalence Prospective Studies Reference Values Reverse Transcriptase Polymerase Chain Reaction Staphylococcus Vertebrates: anatomy and physiology, studies on body, several organs or systems Weight Weight Gain |
| title | Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T02%3A52%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20mother's%20weight%20on%20infant's%20microbiota%20acquisition,%20composition,%20and%20activity%20during%20early%20infancy:%20a%20prospective%20follow-up%20study%20initiated%20in%20early%20pregnancy&rft.jtitle=The%20American%20journal%20of%20clinical%20nutrition&rft.au=Collado,%20Maria%20Carmen&rft.date=2010-11-01&rft.volume=92&rft.issue=5&rft.spage=1023&rft.epage=1030&rft.pages=1023-1030&rft.issn=0002-9165&rft.eissn=1938-3207&rft.coden=AJCNAC&rft_id=info:doi/10.3945/ajcn.2010.29877&rft_dat=%3Cproquest_cross%3E2191282781%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=801740162&rft_id=info:pmid/20844065&rfr_iscdi=true |