Human and rodent type 1 11[beta]-hydroxysteroid dehydrogenases are 7[beta]-hydroxycholesterol dehydrogenases involved in oxysterol metabolism

Interconversion between cortisone and the glucocorticoid receptor ligand cortisol is carried out by 11β-hydroxysteroid dehydrogenase (11β-HSD)isozymes and constitutes a medically important example of pre-receptor control of steroid hormones. The enzyme 11β-HSD type 1 (11β-HSD1) catalyzes the convers...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2004-04, Vol.61 (7-8), p.992
Hauptverfasser:	Hult, M, Elleby, B, Shafqat, N, Svensson, S, Rane, A, Jörnvall, H, Abrahmsen, L, Oppermann, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Dehydrogenase Enzymatic activity Enzymes Hormones Metabolic disorders Rodents Steroid hormones
Online-Zugang:	Volltext
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