Effect of Dexamethasone on Rat Respiratory Pathways
It has been shown that a short-term application (10-15 min) of dexamethasone at a concentration of 1.0 µg/ml decreases the muscular contraction amplitude of the trachea and large bronchi to 76.2 ± 3.5% and increases the dilatational effect of histamine (1.0 µg/ml) to 47.4 ± 8.1% at stimulation of pr...
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| Veröffentlicht in: | Journal of evolutionary biochemistry and physiology 2001-03, Vol.37 (2), p.170 |
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| creator | Fedin, A N Nur, M M Kryukova, E N Vasil'eva, K A |
| description | It has been shown that a short-term application (10-15 min) of dexamethasone at a concentration of 1.0 µg/ml decreases the muscular contraction amplitude of the trachea and large bronchi to 76.2 ± 3.5% and increases the dilatational effect of histamine (1.0 µg/ml) to 47.4 ± 8.1% at stimulation of pre- and postganglionic nerve fibers. Atropine eliminates completely the effect of dexamethasone on the respiratory tract preparation at the stimulation of pre- and postganglionic nerve fibers. The ganglioblocker decreases the dilatational effect at a simultaneous application of atropine and dexamethasone from 47.4 ± 8.1 to 67.2 ± 5.3%. It is concluded that the dexamethasone effect is due to its action on tracheobronchial epithelial receptors and that this effect is mediated by intramural ganglionic neurons.[PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1023/A:1017689031788 |
| format | Article |
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Atropine eliminates completely the effect of dexamethasone on the respiratory tract preparation at the stimulation of pre- and postganglionic nerve fibers. The ganglioblocker decreases the dilatational effect at a simultaneous application of atropine and dexamethasone from 47.4 ± 8.1 to 67.2 ± 5.3%. 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| title | Effect of Dexamethasone on Rat Respiratory Pathways |
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