Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-10, Vol.107 (42), p.18115-18120
Hauptverfasser:	Liu, Huiping, Patel, Manishkumar R., Prescher, Jennifer A., Patsialou, Antonia, Qian, Dalong, Lin, Jiahui, Wen, Susanna, Chang, Ya-Fang, Bachmann, Michael H., Shimono, Yohei, Dalerba, Piero, Adorno, Maddalena, Lobo, Neethan, Bueno, Janet, Dirbas, Frederick M., Goswami, Sumanta, Somlo, George, Condeelis, John, Contag, Christopher H., Gambhir, Sanjiv Sam, Clarke, Michael F., Rowley, Janet D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biological Sciences Breast cancer Breast neoplasms Breast Neoplasms - pathology Cancer Cell growth Disease Models, Animal Genes Humans Imaging Lung Lungs Metastases Metastasis Mice Mice, Inbred NOD Mice, SCID Molecular modelling Neoplasm Metastasis Neoplasm Transplantation Neoplastic Stem Cells - cytology Rodents Stem cells Therapy Tumor cell line Tumor cells Tumors
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