SNARE tagging allows stepwise assembly of a multimodular medicinal toxin

Generation of supramolecular architectures through controlled linking of suitable building blocks can offer new perspectives to medicine and applied technologies. Current linking strategies often rely on chemical methods that have limitations and cannot take full advantage of the recombinant technol...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-10, Vol.107 (42), p.18197-18201
Hauptverfasser:	Darios, Frédéric, Niranjan, Dhevahi, Ferrari, Enrico, Zhang, Fan, Soloviev, Mikhail, Rummel, Andreas, Bigalke, Hans, Suckling, Jason, Ushkaryov, Yuri, Naumenko, Nikolay, Shakirzyanova, Anastasia, Giniatullin, Rashid, Maywood, Elizabeth, Hastings, Michael, Binz, Thomas, Davletov, Bazbek, Südhof, Thomas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biochemistry Biological Sciences Botulinum toxin Botulinum Toxins, Type A - chemistry Botulinum Toxins, Type A - metabolism Cells Data processing Enzymes Exocytosis Fluorescent indicators Genetic recombination Light chains Medical research Membranes Neurons Neurotoxins Neurotransmitters Proteins Proteolytic enzymes Quantum dots R-SNARE Proteins - chemistry R-SNARE Proteins - metabolism Self-assembly SNAP receptors SNAP-25 protein SNARE proteins SNARE Proteins - chemistry SNARE Proteins - metabolism Synapses Synaptobrevin Syntaxin Toxins Translocation
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