Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients
The purpose of this study was to evaluate and compare the diagnostic ability of 2-[(18)F]-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-(123)I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface p...
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| Veröffentlicht in: | Japanese journal of radiology 2007-07, Vol.25 (6), p.255-262 |
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| creator | Nihashi, Takashi Yatsuya, Hiroshi Hayasaka, Kazumasa Kato, Rikio Kawatsu, Shoji Arahata, Yutaka Iwai, Katsushige Takeda, Akinori Washimi, Yukihiko Yoshimura, Kumiko Mizuno, Kanako Kato, Takashi Naganawa, Shinji Ito, Kengo |
| description | The purpose of this study was to evaluate and compare the diagnostic ability of 2-[(18)F]-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-(123)I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD).
FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated.
No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016). |
| doi_str_mv | 10.1007/s11604-007-0132-8 |
| format | Article |
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FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated.
No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).</description><identifier>ISSN: 0288-2043</identifier><identifier>ISSN: 1867-1071</identifier><identifier>EISSN: 1862-5274</identifier><identifier>EISSN: 1867-108X</identifier><identifier>DOI: 10.1007/s11604-007-0132-8</identifier><identifier>PMID: 17634878</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Alzheimer Disease - diagnostic imaging ; Alzheimer's disease ; Antipyrine - analogs & derivatives ; Blood flow ; Cerebral blood flow ; Computed tomography ; Correlation ; Cortex (parietal) ; Emissions ; Glucose ; Glucose-6-Phosphate - analogs & derivatives ; Humans ; Hypometabolism ; Imaging, Three-Dimensional ; Medical imaging ; Neurodegenerative diseases ; Photon emission ; Physicians ; Positron emission ; Positron emission tomography ; Positron-Emission Tomography - methods ; Single photon emission computed tomography ; Tomography ; Tomography, Emission-Computed, Single-Photon - methods</subject><ispartof>Japanese journal of radiology, 2007-07, Vol.25 (6), p.255-262</ispartof><rights>Japan Radiological Society 2007.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-6feffedab31351010eb0284307828e406cfc0583ab08708c043f3f9d64bcfc2c3</citedby><cites>FETCH-LOGICAL-c363t-6feffedab31351010eb0284307828e406cfc0583ab08708c043f3f9d64bcfc2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17634878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nihashi, Takashi</creatorcontrib><creatorcontrib>Yatsuya, Hiroshi</creatorcontrib><creatorcontrib>Hayasaka, Kazumasa</creatorcontrib><creatorcontrib>Kato, Rikio</creatorcontrib><creatorcontrib>Kawatsu, Shoji</creatorcontrib><creatorcontrib>Arahata, Yutaka</creatorcontrib><creatorcontrib>Iwai, Katsushige</creatorcontrib><creatorcontrib>Takeda, Akinori</creatorcontrib><creatorcontrib>Washimi, Yukihiko</creatorcontrib><creatorcontrib>Yoshimura, Kumiko</creatorcontrib><creatorcontrib>Mizuno, Kanako</creatorcontrib><creatorcontrib>Kato, Takashi</creatorcontrib><creatorcontrib>Naganawa, Shinji</creatorcontrib><creatorcontrib>Ito, Kengo</creatorcontrib><title>Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients</title><title>Japanese journal of radiology</title><addtitle>Radiat Med</addtitle><description>The purpose of this study was to evaluate and compare the diagnostic ability of 2-[(18)F]-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-(123)I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD).
FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated.
No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).</description><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer's disease</subject><subject>Antipyrine - analogs & derivatives</subject><subject>Blood flow</subject><subject>Cerebral blood flow</subject><subject>Computed tomography</subject><subject>Correlation</subject><subject>Cortex (parietal)</subject><subject>Emissions</subject><subject>Glucose</subject><subject>Glucose-6-Phosphate - analogs & derivatives</subject><subject>Humans</subject><subject>Hypometabolism</subject><subject>Imaging, Three-Dimensional</subject><subject>Medical imaging</subject><subject>Neurodegenerative diseases</subject><subject>Photon emission</subject><subject>Physicians</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Single photon emission computed tomography</subject><subject>Tomography</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>0288-2043</issn><issn>1867-1071</issn><issn>1862-5274</issn><issn>1867-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1vEzEQhi0EomngB3BBFgd6Mvhj13aOVZKWSkVESjivvN5x62o_gmdXKFz543VIJCQOnObVzDOjefUS8k7wT4Jz8xmF0LxgWTIulGT2BZkJqyUrpSlekhmX1jLJC3VBLhGfeFaF1a_JhTA6K2Nn5PcqJvAj9UO3dyni0FMcp-ZAaxh_AvT0ZnXLNusddX1D775u2HazXu5oGBJtonvoB4z9A71ufz1C7CBdYW4jOAQ6_ZmoFdtuN3nbtQeMSGNPx0eg6DqgezdG6Ed8Q14F1yK8Pdc5-X6z3i2_sPtvt3fL63vmlVYj0wFCgMbVSqhScMGhzgYLxY2VFgquffC8tMrV3BpufXYbVFg0uqjzRHo1J1enu_s0_JgAx6qL6KFtXQ_DhJVVC61LzReZ_Phf0nCjjBUygx_-AZ-GKWWzmSkXsjS2FBkSJ8inATFBqPYpdi4dKsGrY5DVKcjqKI9B5k_m5P358FR30PzdOCenngHoI5eO</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Nihashi, Takashi</creator><creator>Yatsuya, Hiroshi</creator><creator>Hayasaka, Kazumasa</creator><creator>Kato, Rikio</creator><creator>Kawatsu, Shoji</creator><creator>Arahata, Yutaka</creator><creator>Iwai, Katsushige</creator><creator>Takeda, Akinori</creator><creator>Washimi, Yukihiko</creator><creator>Yoshimura, Kumiko</creator><creator>Mizuno, Kanako</creator><creator>Kato, Takashi</creator><creator>Naganawa, Shinji</creator><creator>Ito, Kengo</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200707</creationdate><title>Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients</title><author>Nihashi, Takashi ; Yatsuya, Hiroshi ; Hayasaka, Kazumasa ; Kato, Rikio ; Kawatsu, Shoji ; Arahata, Yutaka ; Iwai, Katsushige ; Takeda, Akinori ; Washimi, Yukihiko ; Yoshimura, Kumiko ; Mizuno, Kanako ; Kato, Takashi ; Naganawa, Shinji ; Ito, Kengo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-6feffedab31351010eb0284307828e406cfc0583ab08708c043f3f9d64bcfc2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer's disease</topic><topic>Antipyrine - analogs & derivatives</topic><topic>Blood flow</topic><topic>Cerebral blood flow</topic><topic>Computed tomography</topic><topic>Correlation</topic><topic>Cortex (parietal)</topic><topic>Emissions</topic><topic>Glucose</topic><topic>Glucose-6-Phosphate - analogs & derivatives</topic><topic>Humans</topic><topic>Hypometabolism</topic><topic>Imaging, Three-Dimensional</topic><topic>Medical imaging</topic><topic>Neurodegenerative diseases</topic><topic>Photon emission</topic><topic>Physicians</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Positron-Emission Tomography - methods</topic><topic>Single photon emission computed tomography</topic><topic>Tomography</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nihashi, Takashi</creatorcontrib><creatorcontrib>Yatsuya, Hiroshi</creatorcontrib><creatorcontrib>Hayasaka, Kazumasa</creatorcontrib><creatorcontrib>Kato, Rikio</creatorcontrib><creatorcontrib>Kawatsu, Shoji</creatorcontrib><creatorcontrib>Arahata, Yutaka</creatorcontrib><creatorcontrib>Iwai, Katsushige</creatorcontrib><creatorcontrib>Takeda, Akinori</creatorcontrib><creatorcontrib>Washimi, Yukihiko</creatorcontrib><creatorcontrib>Yoshimura, Kumiko</creatorcontrib><creatorcontrib>Mizuno, Kanako</creatorcontrib><creatorcontrib>Kato, Takashi</creatorcontrib><creatorcontrib>Naganawa, Shinji</creatorcontrib><creatorcontrib>Ito, Kengo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nihashi, Takashi</au><au>Yatsuya, Hiroshi</au><au>Hayasaka, Kazumasa</au><au>Kato, Rikio</au><au>Kawatsu, Shoji</au><au>Arahata, Yutaka</au><au>Iwai, Katsushige</au><au>Takeda, Akinori</au><au>Washimi, Yukihiko</au><au>Yoshimura, Kumiko</au><au>Mizuno, Kanako</au><au>Kato, Takashi</au><au>Naganawa, Shinji</au><au>Ito, Kengo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients</atitle><jtitle>Japanese journal of radiology</jtitle><addtitle>Radiat Med</addtitle><date>2007-07</date><risdate>2007</risdate><volume>25</volume><issue>6</issue><spage>255</spage><epage>262</epage><pages>255-262</pages><issn>0288-2043</issn><issn>1867-1071</issn><eissn>1862-5274</eissn><eissn>1867-108X</eissn><abstract>The purpose of this study was to evaluate and compare the diagnostic ability of 2-[(18)F]-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-(123)I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD).
FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated.
No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>17634878</pmid><doi>10.1007/s11604-007-0132-8</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0288-2043 |
| ispartof | Japanese journal of radiology, 2007-07, Vol.25 (6), p.255-262 |
| issn | 0288-2043 1867-1071 1862-5274 1867-108X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Alzheimer Disease - diagnostic imaging Alzheimer's disease Antipyrine - analogs & derivatives Blood flow Cerebral blood flow Computed tomography Correlation Cortex (parietal) Emissions Glucose Glucose-6-Phosphate - analogs & derivatives Humans Hypometabolism Imaging, Three-Dimensional Medical imaging Neurodegenerative diseases Photon emission Physicians Positron emission Positron emission tomography Positron-Emission Tomography - methods Single photon emission computed tomography Tomography Tomography, Emission-Computed, Single-Photon - methods |
| title | Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients |
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