Significant Associations between CCL5 Gene Polymorphisms and Post-Transplantational Diabetes Mellitus in Korean Renal Allograft Recipients
Background: Post-transplantational diabetes mellitus (PTDM) is a serious metabolic complication that may follow renal transplantation. The expression of chemokine (C-C motif) ligand 5 (CCL5) is inversely related to pancreatic β-cell function; thus, specific CCL5 gene polymorphisms are considered to...
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| Veröffentlicht in: | American journal of nephrology 2010-10, Vol.32 (4), p.356-361 |
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| creator | Jeong, Kyung-Hwan Moon, Joo-Young Chung, Joo-Ho Kim, Young-Hoon Lee, Tae-Won |
| description | Background: Post-transplantational diabetes mellitus (PTDM) is a serious metabolic complication that may follow renal transplantation. The expression of chemokine (C-C motif) ligand 5 (CCL5) is inversely related to pancreatic β-cell function; thus, specific CCL5 gene polymorphisms are considered to be risk factors for diabetes. In this study, we investigated the association between CCL5 gene polymorphisms and the occurrence of PTDM in Korean patients who had undergone renal transplants. Methods: A total of 311 patients who had received kidney transplants without a prior history of diabetes were included. Three single nucleotide polymorphisms (SNPs) of the CCL5 gene were genotyped from genomic DNA with direct sequencing. Results: PTDM developed in 56 patients (18.0%). The results showed that the allele frequencies of CCL5 gene polymorphisms, rs2107538*T, rs2280789*C and rs3817655*A were significantly higher in the patients with PTDM than in those without PTDM. In multiple logistic regression analysis, 3 SNPs (rs2107538, rs2280789 and rs3817655) of the CCL5 gene were significantly associated with the development of PTDM in the codominant 2 and recessive models. Among haplotypes of the 3 polymorphisms, the frequency of the TCA haplotype was significantly higher in patients with PTDM than in those without PTDM. Conclusions: Our results indicated that genetic polymorphisms of the CCL5 gene were associated with PTDM, suggesting that the CCL5 gene might confer susceptibility to PTDM in patients who receive renal transplants. |
| doi_str_mv | 10.1159/000319704 |
| format | Article |
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The expression of chemokine (C-C motif) ligand 5 (CCL5) is inversely related to pancreatic β-cell function; thus, specific CCL5 gene polymorphisms are considered to be risk factors for diabetes. In this study, we investigated the association between CCL5 gene polymorphisms and the occurrence of PTDM in Korean patients who had undergone renal transplants. Methods: A total of 311 patients who had received kidney transplants without a prior history of diabetes were included. Three single nucleotide polymorphisms (SNPs) of the CCL5 gene were genotyped from genomic DNA with direct sequencing. Results: PTDM developed in 56 patients (18.0%). The results showed that the allele frequencies of CCL5 gene polymorphisms, rs2107538*T, rs2280789*C and rs3817655*A were significantly higher in the patients with PTDM than in those without PTDM. In multiple logistic regression analysis, 3 SNPs (rs2107538, rs2280789 and rs3817655) of the CCL5 gene were significantly associated with the development of PTDM in the codominant 2 and recessive models. Among haplotypes of the 3 polymorphisms, the frequency of the TCA haplotype was significantly higher in patients with PTDM than in those without PTDM. Conclusions: Our results indicated that genetic polymorphisms of the CCL5 gene were associated with PTDM, suggesting that the CCL5 gene might confer susceptibility to PTDM in patients who receive renal transplants.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000319704</identifier><identifier>PMID: 20805685</identifier><identifier>CODEN: AJNED9</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Alleles ; Chemokine CCL5 - genetics ; Diabetes Mellitus - etiology ; Diabetes Mellitus - genetics ; Female ; Haplotypes ; Humans ; Kidney Transplantation - adverse effects ; Logistic Models ; Male ; Middle Aged ; Original Report: Patient-Oriented, Translational Research ; Polymorphism, Single Nucleotide ; Republic of Korea</subject><ispartof>American journal of nephrology, 2010-10, Vol.32 (4), p.356-361</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2010 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-de1ee15ea3109145bf4aa940820e883489210ac55f2e69917b7e00f6fda6cf933</citedby><cites>FETCH-LOGICAL-c364t-de1ee15ea3109145bf4aa940820e883489210ac55f2e69917b7e00f6fda6cf933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2427,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20805685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Kyung-Hwan</creatorcontrib><creatorcontrib>Moon, Joo-Young</creatorcontrib><creatorcontrib>Chung, Joo-Ho</creatorcontrib><creatorcontrib>Kim, Young-Hoon</creatorcontrib><creatorcontrib>Lee, Tae-Won</creatorcontrib><title>Significant Associations between CCL5 Gene Polymorphisms and Post-Transplantational Diabetes Mellitus in Korean Renal Allograft Recipients</title><title>American journal of nephrology</title><addtitle>Am J Nephrol</addtitle><description>Background: Post-transplantational diabetes mellitus (PTDM) is a serious metabolic complication that may follow renal transplantation. The expression of chemokine (C-C motif) ligand 5 (CCL5) is inversely related to pancreatic β-cell function; thus, specific CCL5 gene polymorphisms are considered to be risk factors for diabetes. In this study, we investigated the association between CCL5 gene polymorphisms and the occurrence of PTDM in Korean patients who had undergone renal transplants. Methods: A total of 311 patients who had received kidney transplants without a prior history of diabetes were included. Three single nucleotide polymorphisms (SNPs) of the CCL5 gene were genotyped from genomic DNA with direct sequencing. Results: PTDM developed in 56 patients (18.0%). The results showed that the allele frequencies of CCL5 gene polymorphisms, rs2107538*T, rs2280789*C and rs3817655*A were significantly higher in the patients with PTDM than in those without PTDM. In multiple logistic regression analysis, 3 SNPs (rs2107538, rs2280789 and rs3817655) of the CCL5 gene were significantly associated with the development of PTDM in the codominant 2 and recessive models. Among haplotypes of the 3 polymorphisms, the frequency of the TCA haplotype was significantly higher in patients with PTDM than in those without PTDM. Conclusions: Our results indicated that genetic polymorphisms of the CCL5 gene were associated with PTDM, suggesting that the CCL5 gene might confer susceptibility to PTDM in patients who receive renal transplants.</description><subject>Adult</subject><subject>Alleles</subject><subject>Chemokine CCL5 - genetics</subject><subject>Diabetes Mellitus - etiology</subject><subject>Diabetes Mellitus - genetics</subject><subject>Female</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Report: Patient-Oriented, Translational Research</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Republic of Korea</subject><issn>0250-8095</issn><issn>1421-9670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0UGPEyEYBmBiNG539eDdGOLFeBj9YGAGjk11V2ONRtfzhE4_KusMzAITs3_BXy21tQcvngjkeT8gLyFPGLxiTOrXAFAz3YK4RxZMcFbppoX7ZAFcQqVAyzNyntINAOMK2ofkjIMC2Si5IL--up131vXGZ7pMKfTOZBd8ohvMPxE9Xa3Wkl6hR_o5DHdjiNN3l8ZEjd-Wk5Sr62h8moYy4E_SDPSNMyWNiX7EYXB5TtR5-iFENJ5-wb1YDkPYRWNz2fducuhzekQeWDMkfHxcL8i3y7fXq3fV-tPV-9VyXfV1I3K1RYbIJJqagWZCbqwwRgtQHFCpWijNGZheSsux0Zq1mxYBbGO3pumtrusL8uIwd4rhdsaUu9GlvrzUeAxz6hSTslZSiv_KVpYLG8GaIp__I2_CHMtP90hzYC3nBb08oD6GlCLabopuNPGuY9Dti-xORRb77Dhw3oy4Pcm_zRXw9AB-mLjDeALH_G9VDqHF</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Jeong, Kyung-Hwan</creator><creator>Moon, Joo-Young</creator><creator>Chung, Joo-Ho</creator><creator>Kim, Young-Hoon</creator><creator>Lee, Tae-Won</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>RC3</scope></search><sort><creationdate>201010</creationdate><title>Significant Associations between CCL5 Gene Polymorphisms and Post-Transplantational Diabetes Mellitus in Korean Renal Allograft Recipients</title><author>Jeong, Kyung-Hwan ; Moon, Joo-Young ; Chung, Joo-Ho ; Kim, Young-Hoon ; Lee, Tae-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-de1ee15ea3109145bf4aa940820e883489210ac55f2e69917b7e00f6fda6cf933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Chemokine CCL5 - genetics</topic><topic>Diabetes Mellitus - etiology</topic><topic>Diabetes Mellitus - genetics</topic><topic>Female</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Report: Patient-Oriented, Translational Research</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Republic of Korea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Kyung-Hwan</creatorcontrib><creatorcontrib>Moon, Joo-Young</creatorcontrib><creatorcontrib>Chung, Joo-Ho</creatorcontrib><creatorcontrib>Kim, Young-Hoon</creatorcontrib><creatorcontrib>Lee, Tae-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>Genetics Abstracts</collection><jtitle>American journal of nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Kyung-Hwan</au><au>Moon, Joo-Young</au><au>Chung, Joo-Ho</au><au>Kim, Young-Hoon</au><au>Lee, Tae-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significant Associations between CCL5 Gene Polymorphisms and Post-Transplantational Diabetes Mellitus in Korean Renal Allograft Recipients</atitle><jtitle>American journal of nephrology</jtitle><addtitle>Am J Nephrol</addtitle><date>2010-10</date><risdate>2010</risdate><volume>32</volume><issue>4</issue><spage>356</spage><epage>361</epage><pages>356-361</pages><issn>0250-8095</issn><eissn>1421-9670</eissn><coden>AJNED9</coden><abstract>Background: Post-transplantational diabetes mellitus (PTDM) is a serious metabolic complication that may follow renal transplantation. The expression of chemokine (C-C motif) ligand 5 (CCL5) is inversely related to pancreatic β-cell function; thus, specific CCL5 gene polymorphisms are considered to be risk factors for diabetes. In this study, we investigated the association between CCL5 gene polymorphisms and the occurrence of PTDM in Korean patients who had undergone renal transplants. Methods: A total of 311 patients who had received kidney transplants without a prior history of diabetes were included. Three single nucleotide polymorphisms (SNPs) of the CCL5 gene were genotyped from genomic DNA with direct sequencing. Results: PTDM developed in 56 patients (18.0%). The results showed that the allele frequencies of CCL5 gene polymorphisms, rs2107538*T, rs2280789*C and rs3817655*A were significantly higher in the patients with PTDM than in those without PTDM. In multiple logistic regression analysis, 3 SNPs (rs2107538, rs2280789 and rs3817655) of the CCL5 gene were significantly associated with the development of PTDM in the codominant 2 and recessive models. Among haplotypes of the 3 polymorphisms, the frequency of the TCA haplotype was significantly higher in patients with PTDM than in those without PTDM. Conclusions: Our results indicated that genetic polymorphisms of the CCL5 gene were associated with PTDM, suggesting that the CCL5 gene might confer susceptibility to PTDM in patients who receive renal transplants.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>20805685</pmid><doi>10.1159/000319704</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Alleles Chemokine CCL5 - genetics Diabetes Mellitus - etiology Diabetes Mellitus - genetics Female Haplotypes Humans Kidney Transplantation - adverse effects Logistic Models Male Middle Aged Original Report: Patient-Oriented, Translational Research Polymorphism, Single Nucleotide Republic of Korea |
| title | Significant Associations between CCL5 Gene Polymorphisms and Post-Transplantational Diabetes Mellitus in Korean Renal Allograft Recipients |
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