Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

The endoplasmic reticulum (ER) stress response detects malfunctions in cellular physiology, and microbial pattern recognition receptors recognize external threats posed by infectious agents. This study has investigated whether proinflammatory cytokine expression by monocyte-derived dendritic cells i...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-10, Vol.107 (41), p.17698-17703
Hauptverfasser:	Goodall, Jane C., Wu, Changxin, Zhang, Yongsheng, McNeill, Louise, Ellis, Lou, Saudek, Vladimir, Gaston, J. S. Hill
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Binding sites Biological Sciences CCAAT/enhancer-binding protein Cell Line, Tumor Cells Chlamydia Infections - immunology Chlamydia trachomatis Chromatin Immunoprecipitation Cytokines Dendritic cells Dendritic Cells - immunology Endoplasmic reticulum Endoplasmic Reticulum - immunology Endoplasmic Reticulum - metabolism Environmental factors Enzyme-Linked Immunosorbent Assay Gene expression Gene Expression Regulation - immunology Genes Humans Immune response Immune system Infection Infections Inflammation Integration Interleukin 12 Interleukin 23 Interleukin-23 - immunology Interleukin-23 - metabolism Messenger RNA Monocytes Myeloid cells Oligonucleotide Array Sequence Analysis Pathogens Pattern recognition Promoters Proteins Ribonucleic acid RNA Secretion Stress Stress, Physiological - immunology Toll-like receptors Transcription Factor CHOP - metabolism Transcription factors
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