Subacute systemic toxicity assessment of [beta]-tricalcium phosphate/carboxymethyl-chitin composite implanted in rat femur
The efficacy of a composite of β-tricalcium phosphate particles and carboxymethyl-chitin (β-TCP/CM-chitin) for bone repair has already been established in animal experiments. In the present study, subacute systemic toxicity was evaluated to further assess the biological safety of the implanted compo...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2007-03, Vol.18 (3), p.513 |
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| container_title | Journal of materials science. Materials in medicine |
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| creator | Muramatsu, Kazuaki Oba, Kousuke Mukai, Daisuke Hasegawa, Kazunari Masuda, Shingo Yoshihara, Yusuke |
| description | The efficacy of a composite of β-tricalcium phosphate particles and carboxymethyl-chitin (β-TCP/CM-chitin) for bone repair has already been established in animal experiments. In the present study, subacute systemic toxicity was evaluated to further assess the biological safety of the implanted composite. β-TCP/CM-chitin (approximately 4 mg/kg and 7 mg/kg in male and female rats, respectively) was implanted for 28 days into penetrating defects (2 mm diameter) made artificially in the shaft of the right femur of rats. Sham operation groups with the defect only were prepared as controls. Haematology, blood chemistry, urinalysis, and the histopathology of 44 organs and tissues were investigated. Body weight measurements and clinical observations were performed daily throughout the study. No subacute systemic toxicity possibly caused by the implantation of β-TCP/CM-chitin was detected. These findings indicate that β-TCP/CM-chitin composite is a highly biocompatible bone substitute, at least with an implantation dosage of < 4-7 mg/kg.[PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1007/s10856-007-2012-2 |
| format | Article |
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In the present study, subacute systemic toxicity was evaluated to further assess the biological safety of the implanted composite. β-TCP/CM-chitin (approximately 4 mg/kg and 7 mg/kg in male and female rats, respectively) was implanted for 28 days into penetrating defects (2 mm diameter) made artificially in the shaft of the right femur of rats. Sham operation groups with the defect only were prepared as controls. Haematology, blood chemistry, urinalysis, and the histopathology of 44 organs and tissues were investigated. Body weight measurements and clinical observations were performed daily throughout the study. No subacute systemic toxicity possibly caused by the implantation of β-TCP/CM-chitin was detected. These findings indicate that β-TCP/CM-chitin composite is a highly biocompatible bone substitute, at least with an implantation dosage of < 4-7 mg/kg.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-007-2012-2</identifier><language>eng</language><publisher>London: Springer Nature B.V</publisher><subject>Biomedical materials ; Materials science ; Medical research ; Rodents</subject><ispartof>Journal of materials science. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muramatsu, Kazuaki</au><au>Oba, Kousuke</au><au>Mukai, Daisuke</au><au>Hasegawa, Kazunari</au><au>Masuda, Shingo</au><au>Yoshihara, Yusuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subacute systemic toxicity assessment of [beta]-tricalcium phosphate/carboxymethyl-chitin composite implanted in rat femur</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><date>2007-03-01</date><risdate>2007</risdate><volume>18</volume><issue>3</issue><spage>513</spage><pages>513-</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>The efficacy of a composite of β-tricalcium phosphate particles and carboxymethyl-chitin (β-TCP/CM-chitin) for bone repair has already been established in animal experiments. 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| title | Subacute systemic toxicity assessment of [beta]-tricalcium phosphate/carboxymethyl-chitin composite implanted in rat femur |
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