Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine

Thyroxine can cause cardiac hypertrophy by activating growth factors, such as IGF-I (insulin-like growth factor-I). Since oxidative stress is enhanced in the hyperthyroidism, it would control protein expression involved in this hypertrophy. Male Wistar rats were divided into four groups: (I) control...

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Veröffentlicht in:	Molecular and cellular biochemistry 2007-09, Vol.303 (1-2), p.89-95
Hauptverfasser:	Araujo, A. S. R, Enzveiler, A. T, Schenkel, P, Fernandes, T. R. G, Ribeiro, M. F. M, Partata, W. A, Llesuy, S, Belló-Klein, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Body Weight Cardiomegaly - chemically induced Cardiomegaly - metabolism Cardiomegaly - pathology Drinking water Glutathione Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione transferase Glutathione Transferase - metabolism Growth factors Heart Heart failure Hyperthyroidism Hypertrophy IGF-IR Insulin Insulin-like growth factor I Insulin-like growth factors Lipid peroxidation Lipid Peroxidation - drug effects Lipids Male Muscle contraction Nutrition Oxidation-Reduction Oxidative Stress Peroxidation Protein expression protein synthesis Proteins Rats Rats, Wistar Receptor, IGF Type 1 - metabolism Receptors Rodents Superoxide dismutase Superoxide Dismutase - metabolism Thyroxine Thyroxine - blood Thyroxine - pharmacology Tocopherol Ventricle Vitamin E Vitamin E - pharmacology
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