Effects of vitamin C on muscle glycogen and oxidative events in experimental diabetes
Streptozotocin (STZ) is an agent used in creating experimental diabetes. Varying findings have been reported about the striated muscle glycogen levels in diabetes. In this study, it was planned to observe interaction of vitamin C (AA), of which deficiency has been shown in diabetics, with soleus mus...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2006-11, Vol.292 (1-2), p.131-137 |
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| description | Streptozotocin (STZ) is an agent used in creating experimental diabetes. Varying findings have been reported about the striated muscle glycogen levels in diabetes. In this study, it was planned to observe interaction of vitamin C (AA), of which deficiency has been shown in diabetics, with soleus muscle glycogen levels and oxidative events on STZ-diabetic subjects. Material and Method: In the study, 38 male adult Wistar Albino rats with weights 200 ± 20 g were used by separating them into four groups: Control, Vitamin C, Diabetes, Diabetes + Vitamin C. Body weights and fasting blood glucose were measured at the beginning and end of the experiment. AA, TBARS, GSH, NOx and glycogen levels of soleus muscles, and AA level of blood were measured. The results were compared using Anova variance and Mann-Whitney U tests. Results showed that AA levels in blood increased with vitamin C administration; AA, GSH and NOx levels in the muscle were low and MDA and glycogen levels were high in diabetics; and that vitamin C in the given dosage partially corrected these values. These results indicate that higher dosage than daily 20 mg/kg Vitamin C is required for being effective on metabolic and oxidizing events in diabetic rats. |
| doi_str_mv | 10.1007/s11010-006-9226-3 |
| format | Article |
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Varying findings have been reported about the striated muscle glycogen levels in diabetes. In this study, it was planned to observe interaction of vitamin C (AA), of which deficiency has been shown in diabetics, with soleus muscle glycogen levels and oxidative events on STZ-diabetic subjects. Material and Method: In the study, 38 male adult Wistar Albino rats with weights 200 ± 20 g were used by separating them into four groups: Control, Vitamin C, Diabetes, Diabetes + Vitamin C. Body weights and fasting blood glucose were measured at the beginning and end of the experiment. AA, TBARS, GSH, NOx and glycogen levels of soleus muscles, and AA level of blood were measured. The results were compared using Anova variance and Mann-Whitney U tests. Results showed that AA levels in blood increased with vitamin C administration; AA, GSH and NOx levels in the muscle were low and MDA and glycogen levels were high in diabetics; and that vitamin C in the given dosage partially corrected these values. These results indicate that higher dosage than daily 20 mg/kg Vitamin C is required for being effective on metabolic and oxidizing events in diabetic rats.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-006-9226-3</identifier><identifier>PMID: 16758299</identifier><language>eng</language><publisher>Netherlands: New York : Kluwer Academic Publishers-Plenum Publishers</publisher><subject>Animals ; ascorbic acid ; Ascorbic Acid - blood ; Ascorbic Acid - pharmacology ; Blood ; Blood Glucose ; Body Weight - drug effects ; Diabetes ; Diabetes Mellitus, Experimental - chemically induced ; Glutathione - metabolism ; glycogen ; Glycogen - metabolism ; Male ; Malondialdehyde - metabolism ; Muscle, Skeletal - drug effects ; Muscles ; Nitric Oxide - metabolism ; Organ Size - drug effects ; Oxidation-Reduction - drug effects ; oxidative events ; Rats ; Rats, Wistar ; soleus ; streptozotocin ; Vitamin C</subject><ispartof>Molecular and cellular biochemistry, 2006-11, Vol.292 (1-2), p.131-137</ispartof><rights>Springer Science+Business Media, Inc. 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-b73fe8a399da24545af9c3b41ef1a1df7146c50f1cf36600653b26144b8487a83</citedby><cites>FETCH-LOGICAL-c350t-b73fe8a399da24545af9c3b41ef1a1df7146c50f1cf36600653b26144b8487a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16758299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bulduk, E</creatorcontrib><creatorcontrib>Gönül, B</creatorcontrib><creatorcontrib>Özer, Ç</creatorcontrib><title>Effects of vitamin C on muscle glycogen and oxidative events in experimental diabetes</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><description>Streptozotocin (STZ) is an agent used in creating experimental diabetes. Varying findings have been reported about the striated muscle glycogen levels in diabetes. In this study, it was planned to observe interaction of vitamin C (AA), of which deficiency has been shown in diabetics, with soleus muscle glycogen levels and oxidative events on STZ-diabetic subjects. Material and Method: In the study, 38 male adult Wistar Albino rats with weights 200 ± 20 g were used by separating them into four groups: Control, Vitamin C, Diabetes, Diabetes + Vitamin C. Body weights and fasting blood glucose were measured at the beginning and end of the experiment. AA, TBARS, GSH, NOx and glycogen levels of soleus muscles, and AA level of blood were measured. The results were compared using Anova variance and Mann-Whitney U tests. Results showed that AA levels in blood increased with vitamin C administration; AA, GSH and NOx levels in the muscle were low and MDA and glycogen levels were high in diabetics; and that vitamin C in the given dosage partially corrected these values. These results indicate that higher dosage than daily 20 mg/kg Vitamin C is required for being effective on metabolic and oxidizing events in diabetic rats.</description><subject>Animals</subject><subject>ascorbic acid</subject><subject>Ascorbic Acid - blood</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Blood</subject><subject>Blood Glucose</subject><subject>Body Weight - drug effects</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Glutathione - metabolism</subject><subject>glycogen</subject><subject>Glycogen - metabolism</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscles</subject><subject>Nitric Oxide - metabolism</subject><subject>Organ Size - drug effects</subject><subject>Oxidation-Reduction - drug effects</subject><subject>oxidative events</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>soleus</subject><subject>streptozotocin</subject><subject>Vitamin C</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpFkMtKw0AUhgdRbK0-gBsd3EfPmWuylFIvUHChXQ-TZKak5FIzaWnf3ikpuDoc-P5z-Qi5R3hGAP0SEAEhAVBJxphK-AWZotQ8ERlml2QKHCBJUesJuQlhAxEGxGsyQaVlyrJsSlYL710xBNp5uq8G21QtndOupc0uFLWj6_pYdGvXUtuWtDtUpR2qvaNu79oYirA7bF1fNbG1NS0rm7vBhVty5W0d3N25zsjqbfEz_0iWX--f89dlUnAJQ5Jr7l1qeZaVlgkppPVZwXOBzqPF0msUqpDgsfBcqfim5DlTKESeilTblM_I0zh323e_OxcGs-l2fRtXGi0VA6GYjhCOUNF3IfTOm2082PZHg2BOHs3o0cQF5uTR8Jh5OA_e5Y0r_xNncRF4HAFvO2PXfRXM6psB8igYmRCa_wG6RnZT</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Bulduk, E</creator><creator>Gönül, B</creator><creator>Özer, Ç</creator><general>New York : Kluwer Academic Publishers-Plenum Publishers</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20061101</creationdate><title>Effects of vitamin C on muscle glycogen and oxidative events in experimental diabetes</title><author>Bulduk, E ; Gönül, B ; Özer, Ç</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-b73fe8a399da24545af9c3b41ef1a1df7146c50f1cf36600653b26144b8487a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>ascorbic acid</topic><topic>Ascorbic Acid - blood</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Blood</topic><topic>Blood Glucose</topic><topic>Body Weight - drug effects</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Glutathione - metabolism</topic><topic>glycogen</topic><topic>Glycogen - metabolism</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscles</topic><topic>Nitric Oxide - metabolism</topic><topic>Organ Size - drug effects</topic><topic>Oxidation-Reduction - drug effects</topic><topic>oxidative events</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>soleus</topic><topic>streptozotocin</topic><topic>Vitamin C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bulduk, E</creatorcontrib><creatorcontrib>Gönül, B</creatorcontrib><creatorcontrib>Özer, Ç</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bulduk, E</au><au>Gönül, B</au><au>Özer, Ç</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of vitamin C on muscle glycogen and oxidative events in experimental diabetes</atitle><jtitle>Molecular and cellular biochemistry</jtitle><addtitle>Mol Cell Biochem</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>292</volume><issue>1-2</issue><spage>131</spage><epage>137</epage><pages>131-137</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Streptozotocin (STZ) is an agent used in creating experimental diabetes. Varying findings have been reported about the striated muscle glycogen levels in diabetes. In this study, it was planned to observe interaction of vitamin C (AA), of which deficiency has been shown in diabetics, with soleus muscle glycogen levels and oxidative events on STZ-diabetic subjects. Material and Method: In the study, 38 male adult Wistar Albino rats with weights 200 ± 20 g were used by separating them into four groups: Control, Vitamin C, Diabetes, Diabetes + Vitamin C. Body weights and fasting blood glucose were measured at the beginning and end of the experiment. AA, TBARS, GSH, NOx and glycogen levels of soleus muscles, and AA level of blood were measured. The results were compared using Anova variance and Mann-Whitney U tests. Results showed that AA levels in blood increased with vitamin C administration; AA, GSH and NOx levels in the muscle were low and MDA and glycogen levels were high in diabetics; and that vitamin C in the given dosage partially corrected these values. These results indicate that higher dosage than daily 20 mg/kg Vitamin C is required for being effective on metabolic and oxidizing events in diabetic rats.</abstract><cop>Netherlands</cop><pub>New York : Kluwer Academic Publishers-Plenum Publishers</pub><pmid>16758299</pmid><doi>10.1007/s11010-006-9226-3</doi><tpages>7</tpages></addata></record> |
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| ispartof | Molecular and cellular biochemistry, 2006-11, Vol.292 (1-2), p.131-137 |
| issn | 0300-8177 1573-4919 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals ascorbic acid Ascorbic Acid - blood Ascorbic Acid - pharmacology Blood Blood Glucose Body Weight - drug effects Diabetes Diabetes Mellitus, Experimental - chemically induced Glutathione - metabolism glycogen Glycogen - metabolism Male Malondialdehyde - metabolism Muscle, Skeletal - drug effects Muscles Nitric Oxide - metabolism Organ Size - drug effects Oxidation-Reduction - drug effects oxidative events Rats Rats, Wistar soleus streptozotocin Vitamin C |
| title | Effects of vitamin C on muscle glycogen and oxidative events in experimental diabetes |
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