Mechanism of Enhanced Dermal Permeation of 4-Cyanophenol and Methyl Paraben from Saturated Aqueous Solutions Containing Both Solutes

Dermal permeation through human epidermis and uptake into isolated human stratum corneum (SC) that was and was not delipidized were measured for 2 model compounds, 4-cyanophenol (CP) and methyl paraben (MP), from saturated aqueous solutions containing 1 or both compounds. Because the solutions were...

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Veröffentlicht in:	Skin pharmacology and physiology 2010-01, Vol.23 (3), p.152-163
Hauptverfasser:	Romonchuk, W.J., Bunge, A.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Epidermis - metabolism Excipients - chemistry Excipients - pharmacokinetics Female Humans In Vitro Techniques Lipid Metabolism Male Original Paper Parabens - chemistry Parabens - pharmacokinetics Permeability Phenols - chemistry Phenols - pharmacokinetics Skin Absorption Solubility Thermodynamics
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