Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment

The efficacy of Withania somnifera (Ws) to limit myocardial injury after ischemia and reperfusion was explored and compared to that of Vit E, a reference standard known to reduce mortality and infarct size due to myocardial infarction. Wistar rats (150-200 g) were divided into six groups and receive...

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Veröffentlicht in:	Molecular and cellular biochemistry 2004-05, Vol.260 (1-2), p.39-47
Hauptverfasser:	Gupta, S.K, Mohanty, I, Talwar, K.K, Dinda, A, Joshi, S, Bansal, P, Saxena, A, Arya, D.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Blood Pressure - drug effects Catalase - metabolism Creatine Kinase - metabolism Female Glutathione - metabolism Glutathione Peroxidase - metabolism Heart attacks Heart rate Heart Rate - drug effects herbal medicines Ischemia Isoproterenol - administration & dosage Male Malondialdehyde - metabolism Myocardial infarction Myocardial Infarction - chemically induced Myocardial Infarction - metabolism Myocardial Infarction - prevention & control Myocardial Ischemia - physiopathology Myocardial Ischemia - prevention & control Myocardium - metabolism Myocardium - pathology Necrosis Phytotherapy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Rats Rats, Wistar Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control Rodents Superoxide Dismutase - metabolism Ventricular Pressure - drug effects vitamin E Vitamin E - pharmacology Withania
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