Phosphoinositide 3-kinase activity leads to silica-induced NF-[kappa]B activation through interacting with tyrosine-phosphorylated I[kappa]B-[alpha] and contributing to tyrosine phosphorylation of p65 NF-[kappa]B

The role of the subunits of phosphoinositide (PI) 3-kinase in NF-κB activation in silica-stimulated RAW 264.7 cells was investigated. Results indicate that PI3-kinase activity was increased in response to silica. The p85α subunit of PI3-kinase interacted with tyrosine-phosphorylated IκB-α in silica-...

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Veröffentlicht in:	Molecular and cellular biochemistry 2003-06, Vol.248 (1-2), p.17
Hauptverfasser:	Kang, Jihee Lee, Lee, Hui Su, Pack, In Soon, Hur, Kyu Chung, Castranova, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells Enzymes Phosphorylation Proteins Pyrrolidine Silica
Online-Zugang:	Volltext
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