Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus

To the Editor: Since the outbreak of influenza A (H1N1) virus pandemic, almost 300 cases of infection with an oseltamivir-resistant influenza virus have been reported to the World Health Organization as of June 2010. 1 These strains typically contain a single histidine-to-tyrosine substitution at po...

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Veröffentlicht in:	The New England journal of medicine 2010-09, Vol.363 (14), p.1381-1382
Hauptverfasser:	van der Vries, Erhard, Stelma, Foekje F, Boucher, Charles A.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Antiviral Agents - therapeutic use Child, Preschool Disease Outbreaks Drug Resistance, Multiple, Bacterial - genetics Enzyme Inhibitors - therapeutic use Fatal Outcome Humans Influenza Influenza A Virus, H1N1 Subtype - genetics Influenza, Human - drug therapy Influenza, Human - etiology Influenza, Human - virology Male Mutation Neuraminidase - antagonists & inhibitors Neuraminidase - genetics Oseltamivir - therapeutic use Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Respiratory distress syndrome Viral Load Zanamivir - therapeutic use
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