Sex-specific lung remodeling and inflammation changes in experimental allergic asthma
There is evidence that sex and sex hormones influence the severity of asthma. Airway and lung parenchyma remodeling and the relationship of ultrastructural changes to airway responsiveness and inflammation in male, female, and oophorectomized mice (OVX) were analyzed in experimental chronic allergic...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2010-09, Vol.109 (3), p.855-863 |
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| creator | ANTUNES, Mariana A ABREU, Soraia C SILVA, Adriana L PARRA-CUENTAS, Edwin R AB'SABER, Alexandre M CAPELOZZI, Vera L FERREIRA, Tatiana P. T MARTINS, Marco A SILVA, Patricia M. R ROCCO, Patricia R. M |
| description | There is evidence that sex and sex hormones influence the severity of asthma. Airway and lung parenchyma remodeling and the relationship of ultrastructural changes to airway responsiveness and inflammation in male, female, and oophorectomized mice (OVX) were analyzed in experimental chronic allergic asthma. Seventy-two BALB/c mice were randomly divided into three groups (n=24/each): male, female, and OVX mice, whose ovaries were removed 7 days before the start of sensitization. Each group was further randomized to be sensitized and challenged with ovalbumin (OVA) or saline. Twenty-four hours after the last challenge, collagen fiber content in airways and lung parenchyma, the volume proportion of smooth muscle-specific actin in alveolar ducts and terminal bronchiole, the amount of matrix metalloproteinase (MMP)-2 and MMP-9, and the number of eosinophils and interleukin (IL)-4, IL-5, and transforming growth factor (TGF)-β levels in bronchoalveolar lavage fluid were higher in female than male OVA mice. The response of OVX mice was similar to that of males, except that IL-5 remained higher. Nevertheless, after OVA provocation, airway responsiveness to methacholine was higher in males compared with females and OVX mice. In conclusion, sex influenced the remodeling process, but the mechanisms responsible for airway hyperresponsiveness seemed to differ from those related to remodeling. |
| doi_str_mv | 10.1152/japplphysiol.00333.2010 |
| format | Article |
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T ; MARTINS, Marco A ; SILVA, Patricia M. R ; ROCCO, Patricia R. M</creator><creatorcontrib>ANTUNES, Mariana A ; ABREU, Soraia C ; SILVA, Adriana L ; PARRA-CUENTAS, Edwin R ; AB'SABER, Alexandre M ; CAPELOZZI, Vera L ; FERREIRA, Tatiana P. T ; MARTINS, Marco A ; SILVA, Patricia M. R ; ROCCO, Patricia R. M</creatorcontrib><description>There is evidence that sex and sex hormones influence the severity of asthma. Airway and lung parenchyma remodeling and the relationship of ultrastructural changes to airway responsiveness and inflammation in male, female, and oophorectomized mice (OVX) were analyzed in experimental chronic allergic asthma. Seventy-two BALB/c mice were randomly divided into three groups (n=24/each): male, female, and OVX mice, whose ovaries were removed 7 days before the start of sensitization. Each group was further randomized to be sensitized and challenged with ovalbumin (OVA) or saline. Twenty-four hours after the last challenge, collagen fiber content in airways and lung parenchyma, the volume proportion of smooth muscle-specific actin in alveolar ducts and terminal bronchiole, the amount of matrix metalloproteinase (MMP)-2 and MMP-9, and the number of eosinophils and interleukin (IL)-4, IL-5, and transforming growth factor (TGF)-β levels in bronchoalveolar lavage fluid were higher in female than male OVA mice. The response of OVX mice was similar to that of males, except that IL-5 remained higher. Nevertheless, after OVA provocation, airway responsiveness to methacholine was higher in males compared with females and OVX mice. In conclusion, sex influenced the remodeling process, but the mechanisms responsible for airway hyperresponsiveness seemed to differ from those related to remodeling.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00333.2010</identifier><identifier>PMID: 20634353</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Airway management ; Animals ; Asthma ; Asthma - immunology ; Asthma - metabolism ; Asthma - pathology ; Asthma - physiopathology ; Biological and medical sciences ; Bronchial Hyperreactivity - immunology ; Bronchial Hyperreactivity - metabolism ; Bronchial Hyperreactivity - pathology ; Bronchial Hyperreactivity - physiopathology ; Bronchial Provocation Tests ; Bronchoalveolar Lavage Fluid - cytology ; Bronchoalveolar Lavage Fluid - immunology ; Bronchodilator Agents - administration & dosage ; Chronic Disease ; Collagen ; Collagen - metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Extracellular Matrix - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Hormones ; Inflammation Mediators - metabolism ; Interleukin-4 - metabolism ; Interleukin-5 - metabolism ; Lung - immunology ; Lung - metabolism ; Lung - physiopathology ; Lung - ultrastructure ; Lungs ; Male ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 9 - metabolism ; Methacholine Chloride - administration & dosage ; Mice ; Mice, Inbred BALB C ; Ovalbumin ; Ovariectomy ; Pneumonia - immunology ; Pneumonia - metabolism ; Pneumonia - pathology ; Pneumonia - physiopathology ; Rodents ; Sex Factors ; Time Factors ; Transforming Growth Factor beta - metabolism</subject><ispartof>Journal of applied physiology (1985), 2010-09, Vol.109 (3), p.855-863</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Physiological Society Sep 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-1e03299d4b7f8992eaf28443e4120cd1c84d2b5eefb7860e7aeec7214013f4ab3</citedby><cites>FETCH-LOGICAL-c403t-1e03299d4b7f8992eaf28443e4120cd1c84d2b5eefb7860e7aeec7214013f4ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23190101$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20634353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ANTUNES, Mariana A</creatorcontrib><creatorcontrib>ABREU, Soraia C</creatorcontrib><creatorcontrib>SILVA, Adriana L</creatorcontrib><creatorcontrib>PARRA-CUENTAS, Edwin R</creatorcontrib><creatorcontrib>AB'SABER, Alexandre M</creatorcontrib><creatorcontrib>CAPELOZZI, Vera L</creatorcontrib><creatorcontrib>FERREIRA, Tatiana P. T</creatorcontrib><creatorcontrib>MARTINS, Marco A</creatorcontrib><creatorcontrib>SILVA, Patricia M. R</creatorcontrib><creatorcontrib>ROCCO, Patricia R. M</creatorcontrib><title>Sex-specific lung remodeling and inflammation changes in experimental allergic asthma</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>There is evidence that sex and sex hormones influence the severity of asthma. Airway and lung parenchyma remodeling and the relationship of ultrastructural changes to airway responsiveness and inflammation in male, female, and oophorectomized mice (OVX) were analyzed in experimental chronic allergic asthma. Seventy-two BALB/c mice were randomly divided into three groups (n=24/each): male, female, and OVX mice, whose ovaries were removed 7 days before the start of sensitization. Each group was further randomized to be sensitized and challenged with ovalbumin (OVA) or saline. Twenty-four hours after the last challenge, collagen fiber content in airways and lung parenchyma, the volume proportion of smooth muscle-specific actin in alveolar ducts and terminal bronchiole, the amount of matrix metalloproteinase (MMP)-2 and MMP-9, and the number of eosinophils and interleukin (IL)-4, IL-5, and transforming growth factor (TGF)-β levels in bronchoalveolar lavage fluid were higher in female than male OVA mice. The response of OVX mice was similar to that of males, except that IL-5 remained higher. Nevertheless, after OVA provocation, airway responsiveness to methacholine was higher in males compared with females and OVX mice. In conclusion, sex influenced the remodeling process, but the mechanisms responsible for airway hyperresponsiveness seemed to differ from those related to remodeling.</description><subject>Airway management</subject><subject>Animals</subject><subject>Asthma</subject><subject>Asthma - immunology</subject><subject>Asthma - metabolism</subject><subject>Asthma - pathology</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bronchial Hyperreactivity - immunology</subject><subject>Bronchial Hyperreactivity - metabolism</subject><subject>Bronchial Hyperreactivity - pathology</subject><subject>Bronchial Hyperreactivity - physiopathology</subject><subject>Bronchial Provocation Tests</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Bronchodilator Agents - administration & dosage</subject><subject>Chronic Disease</subject><subject>Collagen</subject><subject>Collagen - metabolism</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Extracellular Matrix - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukin-4 - metabolism</subject><subject>Interleukin-5 - metabolism</subject><subject>Lung - immunology</subject><subject>Lung - metabolism</subject><subject>Lung - physiopathology</subject><subject>Lung - ultrastructure</subject><subject>Lungs</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>Methacholine Chloride - administration & dosage</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Ovalbumin</subject><subject>Ovariectomy</subject><subject>Pneumonia - immunology</subject><subject>Pneumonia - metabolism</subject><subject>Pneumonia - pathology</subject><subject>Pneumonia - physiopathology</subject><subject>Rodents</subject><subject>Sex Factors</subject><subject>Time Factors</subject><subject>Transforming Growth Factor beta - metabolism</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1v1DAQhi0EotvCX4AIiWOWGX-skyOqWlqpEgfoOZo4492snA_srNT993XpFnqyZT_vO6NHiM8Ia0Qjv-1pnsO8O6Z-CmsApdRaAsIbscq_ssQN4FuxqqyB0prKnonzlPYAqLXB9-JMwkZpZdRK3P_ihzLN7HrfuyIcxm0ReZg6Dn2-0tgV_egDDQMt_TQWbkfjllN-LPhh5tgPPC4UCgqB4zY3UFp2A30Q7zyFxB9P54W4v776fXlT3v38cXv5_a50GtRSIoOSdd3p1vqqriWTl5XWijVKcB26SneyNcy-tdUG2BKzsxI1oPKaWnUhvjz3znH6c-C0NPvpEMc8srHGAGJtZIbsM-TilFJk38x5b4rHBqF5stm8ttn8tdk82czJT6f6Qztw9y_3oi8DX08AJUfBRxpdn_5zCuvcg-oRWCOCIg</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>ANTUNES, Mariana A</creator><creator>ABREU, Soraia C</creator><creator>SILVA, Adriana L</creator><creator>PARRA-CUENTAS, Edwin R</creator><creator>AB'SABER, Alexandre M</creator><creator>CAPELOZZI, Vera L</creator><creator>FERREIRA, Tatiana P. T</creator><creator>MARTINS, Marco A</creator><creator>SILVA, Patricia M. R</creator><creator>ROCCO, Patricia R. M</creator><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100901</creationdate><title>Sex-specific lung remodeling and inflammation changes in experimental allergic asthma</title><author>ANTUNES, Mariana A ; ABREU, Soraia C ; SILVA, Adriana L ; PARRA-CUENTAS, Edwin R ; AB'SABER, Alexandre M ; CAPELOZZI, Vera L ; FERREIRA, Tatiana P. T ; MARTINS, Marco A ; SILVA, Patricia M. R ; ROCCO, Patricia R. 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Psychology</topic><topic>Hormones</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukin-4 - metabolism</topic><topic>Interleukin-5 - metabolism</topic><topic>Lung - immunology</topic><topic>Lung - metabolism</topic><topic>Lung - physiopathology</topic><topic>Lung - ultrastructure</topic><topic>Lungs</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>Methacholine Chloride - administration & dosage</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Ovalbumin</topic><topic>Ovariectomy</topic><topic>Pneumonia - immunology</topic><topic>Pneumonia - metabolism</topic><topic>Pneumonia - pathology</topic><topic>Pneumonia - physiopathology</topic><topic>Rodents</topic><topic>Sex Factors</topic><topic>Time Factors</topic><topic>Transforming Growth Factor beta - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANTUNES, Mariana A</creatorcontrib><creatorcontrib>ABREU, Soraia C</creatorcontrib><creatorcontrib>SILVA, Adriana L</creatorcontrib><creatorcontrib>PARRA-CUENTAS, Edwin R</creatorcontrib><creatorcontrib>AB'SABER, Alexandre M</creatorcontrib><creatorcontrib>CAPELOZZI, Vera L</creatorcontrib><creatorcontrib>FERREIRA, Tatiana P. 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T</au><au>MARTINS, Marco A</au><au>SILVA, Patricia M. R</au><au>ROCCO, Patricia R. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-specific lung remodeling and inflammation changes in experimental allergic asthma</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>109</volume><issue>3</issue><spage>855</spage><epage>863</epage><pages>855-863</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>There is evidence that sex and sex hormones influence the severity of asthma. Airway and lung parenchyma remodeling and the relationship of ultrastructural changes to airway responsiveness and inflammation in male, female, and oophorectomized mice (OVX) were analyzed in experimental chronic allergic asthma. Seventy-two BALB/c mice were randomly divided into three groups (n=24/each): male, female, and OVX mice, whose ovaries were removed 7 days before the start of sensitization. Each group was further randomized to be sensitized and challenged with ovalbumin (OVA) or saline. Twenty-four hours after the last challenge, collagen fiber content in airways and lung parenchyma, the volume proportion of smooth muscle-specific actin in alveolar ducts and terminal bronchiole, the amount of matrix metalloproteinase (MMP)-2 and MMP-9, and the number of eosinophils and interleukin (IL)-4, IL-5, and transforming growth factor (TGF)-β levels in bronchoalveolar lavage fluid were higher in female than male OVA mice. The response of OVX mice was similar to that of males, except that IL-5 remained higher. Nevertheless, after OVA provocation, airway responsiveness to methacholine was higher in males compared with females and OVX mice. In conclusion, sex influenced the remodeling process, but the mechanisms responsible for airway hyperresponsiveness seemed to differ from those related to remodeling.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub><pmid>20634353</pmid><doi>10.1152/japplphysiol.00333.2010</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Airway management Animals Asthma Asthma - immunology Asthma - metabolism Asthma - pathology Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - pathology Bronchial Hyperreactivity - physiopathology Bronchial Provocation Tests Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Bronchodilator Agents - administration & dosage Chronic Disease Collagen Collagen - metabolism Disease Models, Animal Dose-Response Relationship, Drug Extracellular Matrix - metabolism Female Fundamental and applied biological sciences. Psychology Hormones Inflammation Mediators - metabolism Interleukin-4 - metabolism Interleukin-5 - metabolism Lung - immunology Lung - metabolism Lung - physiopathology Lung - ultrastructure Lungs Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Methacholine Chloride - administration & dosage Mice Mice, Inbred BALB C Ovalbumin Ovariectomy Pneumonia - immunology Pneumonia - metabolism Pneumonia - pathology Pneumonia - physiopathology Rodents Sex Factors Time Factors Transforming Growth Factor beta - metabolism |
| title | Sex-specific lung remodeling and inflammation changes in experimental allergic asthma |
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