Structure-based modeling of the functional HIV-1 intasome and its inhibition

The intasome is the basic recombination unit of retroviral integration, comprising the integrase protein and the ends of the viral DNA made by reverse transcription. Clinical inhibitors preferentially target the DNA-bound form of integrase as compared with the free protein, highlighting the critical...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-09, Vol.107 (36), p.15910-15915
Hauptverfasser:	Krishnan, Lavanya, Li, Xiang, Naraharisetty, Hema L., Hare, Stephen, Cherepanov, Peter, Engelman, Alan, Coffin, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Biochemistry Biological Sciences Crystal structure Deoxyribonucleic acid DNA Drug interactions Drugs Foamy virus Genetic mutation HIV HIV 1 HIV-1 - chemistry HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Inhibitor drugs Integrase Integration Metal ions Models, Theoretical Protein Conformation Protein structure Proteins Quaternary structure Recombination Reverse transcription Structure-function relationships Viral DNA Viral morphology
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