Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case–control study in Japan
Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine. Howeve...
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| Veröffentlicht in: | British journal of nutrition 2010-09, Vol.104 (5), p.757-764 |
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| creator | Murakami, Kentaro Miyake, Yoshihiro Sasaki, Satoshi Tanaka, Keiko Fukushima, Wakaba Kiyohara, Chikako Tsuboi, Yoshio Yamada, Tatsuo Oeda, Tomoko Miki, Takami Kawamura, Nobutoshi Sakae, Nobutaka Fukuyama, Hidenao Hirota, Yoshio Nagai, Masaki |
| description | Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine. However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case–control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n 249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0·87, 0·70 and 0·11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0·56 (0·33, 0·94), 0·69 (0·38, 1·25) and 0·48 (0·23, 0·99), respectively (P for trend = 0·10). In conclusion, in the present case–control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD. |
| doi_str_mv | 10.1017/S0007114510001005 |
| format | Article |
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However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case–control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n 249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0·87, 0·70 and 0·11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0·56 (0·33, 0·94), 0·69 (0·38, 1·25) and 0·48 (0·23, 0·99), respectively (P for trend = 0·10). In conclusion, in the present case–control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114510001005</identifier><identifier>PMID: 20338075</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>adults ; Aged ; biochemical pathways ; Biological and medical sciences ; blood chemistry ; Case studies ; Case-Control Studies ; Clinical trials ; Diet ; Diet Surveys ; dietary surveys ; Dietary Surveys and Nutritional Epidemiology ; Disease prevention ; epidemiology ; Feeding. Feeding behavior ; Female ; Folate ; folic acid ; Folic Acid - administration & dosage ; food intake ; Fundamental and applied biological sciences. Psychology ; homocysteine ; Humans ; Japan ; Male ; Middle Aged ; nervous system diseases ; nutrient intake ; nutritional status ; Odds Ratio ; Parkinson disease ; Parkinson Disease - etiology ; Parkinson's disease ; pyridoxine ; riboflavin ; Riboflavin - administration & dosage ; risk assessment ; Risk Factors ; Surveys and Questionnaires ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin B ; Vitamin B 12 - administration & dosage ; Vitamin B 6 - administration & dosage ; Vitamin B Complex - administration & dosage ; Vitamin B12 ; Vitamin B6 ; Vitamins</subject><ispartof>British journal of nutrition, 2010-09, Vol.104 (5), p.757-764</ispartof><rights>Copyright © The Authors 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114510001005/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,781,785,27929,27930,55633</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23269548$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20338075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murakami, Kentaro</creatorcontrib><creatorcontrib>Miyake, Yoshihiro</creatorcontrib><creatorcontrib>Sasaki, Satoshi</creatorcontrib><creatorcontrib>Tanaka, Keiko</creatorcontrib><creatorcontrib>Fukushima, Wakaba</creatorcontrib><creatorcontrib>Kiyohara, Chikako</creatorcontrib><creatorcontrib>Tsuboi, Yoshio</creatorcontrib><creatorcontrib>Yamada, Tatsuo</creatorcontrib><creatorcontrib>Oeda, Tomoko</creatorcontrib><creatorcontrib>Miki, Takami</creatorcontrib><creatorcontrib>Kawamura, Nobutoshi</creatorcontrib><creatorcontrib>Sakae, Nobutaka</creatorcontrib><creatorcontrib>Fukuyama, Hidenao</creatorcontrib><creatorcontrib>Hirota, Yoshio</creatorcontrib><creatorcontrib>Nagai, Masaki</creatorcontrib><creatorcontrib>Fukuoka Kinki Parkinson's Disease Study Group</creatorcontrib><title>Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case–control study in Japan</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine. However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case–control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n 249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0·87, 0·70 and 0·11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0·56 (0·33, 0·94), 0·69 (0·38, 1·25) and 0·48 (0·23, 0·99), respectively (P for trend = 0·10). In conclusion, in the present case–control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD.</description><subject>adults</subject><subject>Aged</subject><subject>biochemical pathways</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>Case studies</subject><subject>Case-Control Studies</subject><subject>Clinical trials</subject><subject>Diet</subject><subject>Diet Surveys</subject><subject>dietary surveys</subject><subject>Dietary Surveys and Nutritional Epidemiology</subject><subject>Disease prevention</subject><subject>epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Folate</subject><subject>folic acid</subject><subject>Folic Acid - administration & dosage</subject><subject>food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>homocysteine</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nervous system diseases</subject><subject>nutrient intake</subject><subject>nutritional status</subject><subject>Odds Ratio</subject><subject>Parkinson disease</subject><subject>Parkinson Disease - etiology</subject><subject>Parkinson's disease</subject><subject>pyridoxine</subject><subject>riboflavin</subject><subject>Riboflavin - administration & dosage</subject><subject>risk assessment</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin B</subject><subject>Vitamin B 12 - administration & dosage</subject><subject>Vitamin B 6 - administration & dosage</subject><subject>Vitamin B Complex - administration & dosage</subject><subject>Vitamin B12</subject><subject>Vitamin B6</subject><subject>Vitamins</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNplks1u1DAQxy0EokvhAbiAhVRxIeCP2I659YsCqgRVqThak2RcuZuNt3G2ghs8Q9-QJ8FRForEwZoZz29mNH8NIU85e80ZN2_OGWOG81Lx7OSn7pEFL40qhNbiPllM6WLK75BHKV3lsOLMPiQ7gklZMaMW5OdRwBGG7zT0IyyRRk997GDEV_QmjLAKPT3Q__hcUOhbOoQ6-g5u8tccpuVU-hmGZehT7F8m2oaEkPAtBdpk--vHbRP7cYgdTeOmnQbSj7CG_jF54KFL-GRrd8nFu-Mvh--L008nHw73T4tGirwSZ60C3qJh3oC2iGBNVVe1hBrQas-sMtaXUnABiEKiZYiyaU1268zKXfJi7rse4vUG0-iu4mbo80hnFJOK2arK0LMttKlX2Lr1EFZZHfdHsAzsbQFIDXR-gL4J6Y6TQltVTo2KmQtpxG9_81kfp400yumTM1dxe3Sm-VdXZv75zHuIDi6zoO7iXDAuGa8qzYzMhJyJBlb1ENpLvFuAMzcdhPvvIORvTeOhrA</recordid><startdate>20100914</startdate><enddate>20100914</enddate><creator>Murakami, Kentaro</creator><creator>Miyake, Yoshihiro</creator><creator>Sasaki, Satoshi</creator><creator>Tanaka, Keiko</creator><creator>Fukushima, Wakaba</creator><creator>Kiyohara, Chikako</creator><creator>Tsuboi, Yoshio</creator><creator>Yamada, Tatsuo</creator><creator>Oeda, Tomoko</creator><creator>Miki, Takami</creator><creator>Kawamura, Nobutoshi</creator><creator>Sakae, Nobutaka</creator><creator>Fukuyama, Hidenao</creator><creator>Hirota, Yoshio</creator><creator>Nagai, Masaki</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20100914</creationdate><title>Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case–control study in Japan</title><author>Murakami, Kentaro ; Miyake, Yoshihiro ; Sasaki, Satoshi ; Tanaka, Keiko ; Fukushima, Wakaba ; Kiyohara, Chikako ; Tsuboi, Yoshio ; Yamada, Tatsuo ; Oeda, Tomoko ; Miki, Takami ; Kawamura, Nobutoshi ; Sakae, Nobutaka ; Fukuyama, Hidenao ; Hirota, Yoshio ; Nagai, Masaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3275-10d5a1de70f7a69eea978b8b3abae96f09579f43212aee23e90ee3cd723eba973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>adults</topic><topic>Aged</topic><topic>biochemical pathways</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>Case studies</topic><topic>Case-Control Studies</topic><topic>Clinical trials</topic><topic>Diet</topic><topic>Diet Surveys</topic><topic>dietary surveys</topic><topic>Dietary Surveys and Nutritional Epidemiology</topic><topic>Disease prevention</topic><topic>epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Folate</topic><topic>folic acid</topic><topic>Folic Acid - administration & dosage</topic><topic>food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>homocysteine</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nervous system diseases</topic><topic>nutrient intake</topic><topic>nutritional status</topic><topic>Odds Ratio</topic><topic>Parkinson disease</topic><topic>Parkinson Disease - etiology</topic><topic>Parkinson's disease</topic><topic>pyridoxine</topic><topic>riboflavin</topic><topic>Riboflavin - administration & dosage</topic><topic>risk assessment</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin B</topic><topic>Vitamin B 12 - administration & dosage</topic><topic>Vitamin B 6 - administration & dosage</topic><topic>Vitamin B Complex - administration & dosage</topic><topic>Vitamin B12</topic><topic>Vitamin B6</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murakami, Kentaro</creatorcontrib><creatorcontrib>Miyake, Yoshihiro</creatorcontrib><creatorcontrib>Sasaki, Satoshi</creatorcontrib><creatorcontrib>Tanaka, Keiko</creatorcontrib><creatorcontrib>Fukushima, Wakaba</creatorcontrib><creatorcontrib>Kiyohara, Chikako</creatorcontrib><creatorcontrib>Tsuboi, Yoshio</creatorcontrib><creatorcontrib>Yamada, Tatsuo</creatorcontrib><creatorcontrib>Oeda, Tomoko</creatorcontrib><creatorcontrib>Miki, Takami</creatorcontrib><creatorcontrib>Kawamura, Nobutoshi</creatorcontrib><creatorcontrib>Sakae, Nobutaka</creatorcontrib><creatorcontrib>Fukuyama, Hidenao</creatorcontrib><creatorcontrib>Hirota, Yoshio</creatorcontrib><creatorcontrib>Nagai, Masaki</creatorcontrib><creatorcontrib>Fukuoka Kinki Parkinson's Disease Study 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Wakaba</au><au>Kiyohara, Chikako</au><au>Tsuboi, Yoshio</au><au>Yamada, Tatsuo</au><au>Oeda, Tomoko</au><au>Miki, Takami</au><au>Kawamura, Nobutoshi</au><au>Sakae, Nobutaka</au><au>Fukuyama, Hidenao</au><au>Hirota, Yoshio</au><au>Nagai, Masaki</au><aucorp>Fukuoka Kinki Parkinson's Disease Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case–control study in Japan</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2010-09-14</date><risdate>2010</risdate><volume>104</volume><issue>5</issue><spage>757</spage><epage>764</epage><pages>757-764</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine. However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case–control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n 249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0·87, 0·70 and 0·11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0·56 (0·33, 0·94), 0·69 (0·38, 1·25) and 0·48 (0·23, 0·99), respectively (P for trend = 0·10). In conclusion, in the present case–control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>20338075</pmid><doi>10.1017/S0007114510001005</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2010-09, Vol.104 (5), p.757-764 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_proquest_journals_750350988 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Cambridge Journals; Free Full-Text Journals in Chemistry |
| subjects | adults Aged biochemical pathways Biological and medical sciences blood chemistry Case studies Case-Control Studies Clinical trials Diet Diet Surveys dietary surveys Dietary Surveys and Nutritional Epidemiology Disease prevention epidemiology Feeding. Feeding behavior Female Folate folic acid Folic Acid - administration & dosage food intake Fundamental and applied biological sciences. Psychology homocysteine Humans Japan Male Middle Aged nervous system diseases nutrient intake nutritional status Odds Ratio Parkinson disease Parkinson Disease - etiology Parkinson's disease pyridoxine riboflavin Riboflavin - administration & dosage risk assessment Risk Factors Surveys and Questionnaires Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin B Vitamin B 12 - administration & dosage Vitamin B 6 - administration & dosage Vitamin B Complex - administration & dosage Vitamin B12 Vitamin B6 Vitamins |
| title | Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case–control study in Japan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T16%3A51%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20intake%20of%20folate,%20vitamin%20B6,%20vitamin%20B12%20and%20riboflavin%20and%20risk%20of%20Parkinson's%20disease:%20a%20case%E2%80%93control%20study%20in%20Japan&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Murakami,%20Kentaro&rft.aucorp=Fukuoka%20Kinki%20Parkinson's%20Disease%20Study%20Group&rft.date=2010-09-14&rft.volume=104&rft.issue=5&rft.spage=757&rft.epage=764&rft.pages=757-764&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1017/S0007114510001005&rft_dat=%3Cproquest_pubme%3E2136775631%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=750350988&rft_id=info:pmid/20338075&rft_cupid=10_1017_S0007114510001005&rfr_iscdi=true |