PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG
Purpose The aim of this study was to evaluate inflammation and tumour imaging with a vascular adhesion protein 1 (VAP-1) targeting peptide 68 Ga-DOTAVAP-P1 in comparison with 18 F-FDG. Methods Rats with both subcutaneous human pancreatic adenocarcinoma xenografts and turpentine oil-induced acute ste...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2010-10, Vol.37 (10), p.1918-1925 |
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| creator | Autio, Anu Ujula, Tiina Luoto, Pauliina Salomäki, Satu Jalkanen, Sirpa Roivainen, Anne |
| description | Purpose
The aim of this study was to evaluate inflammation and tumour imaging with a vascular adhesion protein 1 (VAP-1) targeting peptide
68
Ga-DOTAVAP-P1 in comparison with
18
F-FDG.
Methods
Rats with both subcutaneous human pancreatic adenocarcinoma xenografts and turpentine oil-induced acute sterile inflammation were evaluated by dynamic positron emission tomography (PET) and by digital autoradiography of tissue cryosections. Subsequently, the autoradiographs were combined with histological and immunohistological analysis of the sections.
Results
68
Ga-DOTAVAP-P1 delineated acute, sterile inflammation comparable with
18
F-FDG. However, the tumour uptake of
68
Ga-DOTAVAP-P1 was low in contrast to prominent
18
F-FDG uptake. The standardised uptake values of inflammation and tumours by PET were 1.1 ± 0.4 (mean ± SEM) and 0.4 ± 0.1 for
68
Ga-DOTAVAP-P1 and 2.0 ± 0.5 and 1.6 ± 0.8 for
18
F-FDG, respectively. In addition, PET studies showed inflammation to muscle and tumour to muscle ratios of 5.1 ± 3.1 and 1.7 ± 0.3 for
68
Ga-DOTAVAP-P1 and 6.2 ± 0.7 and 4.6 ± 2.2 for
18
F-FDG, respectively. Immunohistochemistry revealed increased expression of luminal VAP-1 on the endothelium at the site of inflammation and low expression in the tumour
Conclusion
The
68
Ga-DOTAVAP-P1 PET was able to visualise inflammation better than tumour, which was in accordance with the luminal expression of VAP-1 on vasculature in these experimental models. |
| doi_str_mv | 10.1007/s00259-010-1497-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_750268916</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2136005421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-721c4e1fd05adafa3d58b6092f08b79922bc21a54abd8ed21db5656a6de6cbae3</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxiMEov94AC7I4m4YezeOzW3VdrdIlbqHpddoYjupq40TbAe6L9LnxdGWcuI0M_Lv-8aaryg-MvjCAKqvEYCXigIDypaqooc3xSkTTNEKpHr72ldwUpzF-AjAJJfqfXHCoeQLJeVp8by93hHXY-d8R4aWON_use8xucET9IagsX7QGLTzQ4_kKU9dwDZFMsVZ8wujnvYYMvhg46waw5Cs84SRhKGzaaZGOyZnLBFyg_Tqbre6X23pln0jeuhHDC5m3W-XHgiTa7q-2lwU71rcR_vhpZ4XP9bXu8sbenu3-X65uqV6AZBoxZleWtYaKNFgiwtTykaA4i3IplKK80ZzhuUSGyOt4cw0pSgFCmOFbtAuzovPR9_86Z-Tjal-HKbg88q6KoELqZjIEDtCOgwxBtvWY8gnC4eaQT0HUR-DqGGecxD1IWs-vRhPTW_Nq-Lv5TPAj0DMT76z4d_m_7v-AWDKlUs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>750268916</pqid></control><display><type>article</type><title>PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Autio, Anu ; Ujula, Tiina ; Luoto, Pauliina ; Salomäki, Satu ; Jalkanen, Sirpa ; Roivainen, Anne</creator><creatorcontrib>Autio, Anu ; Ujula, Tiina ; Luoto, Pauliina ; Salomäki, Satu ; Jalkanen, Sirpa ; Roivainen, Anne</creatorcontrib><description>Purpose
The aim of this study was to evaluate inflammation and tumour imaging with a vascular adhesion protein 1 (VAP-1) targeting peptide
68
Ga-DOTAVAP-P1 in comparison with
18
F-FDG.
Methods
Rats with both subcutaneous human pancreatic adenocarcinoma xenografts and turpentine oil-induced acute sterile inflammation were evaluated by dynamic positron emission tomography (PET) and by digital autoradiography of tissue cryosections. Subsequently, the autoradiographs were combined with histological and immunohistological analysis of the sections.
Results
68
Ga-DOTAVAP-P1 delineated acute, sterile inflammation comparable with
18
F-FDG. However, the tumour uptake of
68
Ga-DOTAVAP-P1 was low in contrast to prominent
18
F-FDG uptake. The standardised uptake values of inflammation and tumours by PET were 1.1 ± 0.4 (mean ± SEM) and 0.4 ± 0.1 for
68
Ga-DOTAVAP-P1 and 2.0 ± 0.5 and 1.6 ± 0.8 for
18
F-FDG, respectively. In addition, PET studies showed inflammation to muscle and tumour to muscle ratios of 5.1 ± 3.1 and 1.7 ± 0.3 for
68
Ga-DOTAVAP-P1 and 6.2 ± 0.7 and 4.6 ± 2.2 for
18
F-FDG, respectively. Immunohistochemistry revealed increased expression of luminal VAP-1 on the endothelium at the site of inflammation and low expression in the tumour
Conclusion
The
68
Ga-DOTAVAP-P1 PET was able to visualise inflammation better than tumour, which was in accordance with the luminal expression of VAP-1 on vasculature in these experimental models.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-010-1497-y</identifier><identifier>PMID: 20523988</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Amine Oxidase (Copper-Containing) - metabolism ; Animals ; Cardiology ; Cell Adhesion Molecules - metabolism ; Cell Line, Tumor ; Cell Transformation, Neoplastic ; Fluorodeoxyglucose F18 ; Gallium Radioisotopes ; Gene Expression Regulation, Neoplastic ; Heterocyclic Compounds, 1-Ring - chemistry ; Humans ; Imaging ; Inflammation - diagnostic imaging ; Inflammation - metabolism ; Male ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Pancreatic cancer ; Pancreatic Neoplasms - diagnostic imaging ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - metabolism ; Pancreatic Neoplasms - pathology ; Peptides - chemistry ; Peptides - metabolism ; Positron-Emission Tomography ; Proteins ; Radiology ; Rats ; Rodents ; Skin Diseases - diagnostic imaging ; Skin Diseases - metabolism ; Tomography ; Tumors</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2010-10, Vol.37 (10), p.1918-1925</ispartof><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c300t-721c4e1fd05adafa3d58b6092f08b79922bc21a54abd8ed21db5656a6de6cbae3</citedby><cites>FETCH-LOGICAL-c300t-721c4e1fd05adafa3d58b6092f08b79922bc21a54abd8ed21db5656a6de6cbae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-010-1497-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-010-1497-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20523988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Autio, Anu</creatorcontrib><creatorcontrib>Ujula, Tiina</creatorcontrib><creatorcontrib>Luoto, Pauliina</creatorcontrib><creatorcontrib>Salomäki, Satu</creatorcontrib><creatorcontrib>Jalkanen, Sirpa</creatorcontrib><creatorcontrib>Roivainen, Anne</creatorcontrib><title>PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
The aim of this study was to evaluate inflammation and tumour imaging with a vascular adhesion protein 1 (VAP-1) targeting peptide
68
Ga-DOTAVAP-P1 in comparison with
18
F-FDG.
Methods
Rats with both subcutaneous human pancreatic adenocarcinoma xenografts and turpentine oil-induced acute sterile inflammation were evaluated by dynamic positron emission tomography (PET) and by digital autoradiography of tissue cryosections. Subsequently, the autoradiographs were combined with histological and immunohistological analysis of the sections.
Results
68
Ga-DOTAVAP-P1 delineated acute, sterile inflammation comparable with
18
F-FDG. However, the tumour uptake of
68
Ga-DOTAVAP-P1 was low in contrast to prominent
18
F-FDG uptake. The standardised uptake values of inflammation and tumours by PET were 1.1 ± 0.4 (mean ± SEM) and 0.4 ± 0.1 for
68
Ga-DOTAVAP-P1 and 2.0 ± 0.5 and 1.6 ± 0.8 for
18
F-FDG, respectively. In addition, PET studies showed inflammation to muscle and tumour to muscle ratios of 5.1 ± 3.1 and 1.7 ± 0.3 for
68
Ga-DOTAVAP-P1 and 6.2 ± 0.7 and 4.6 ± 2.2 for
18
F-FDG, respectively. Immunohistochemistry revealed increased expression of luminal VAP-1 on the endothelium at the site of inflammation and low expression in the tumour
Conclusion
The
68
Ga-DOTAVAP-P1 PET was able to visualise inflammation better than tumour, which was in accordance with the luminal expression of VAP-1 on vasculature in these experimental models.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Amine Oxidase (Copper-Containing) - metabolism</subject><subject>Animals</subject><subject>Cardiology</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Transformation, Neoplastic</subject><subject>Fluorodeoxyglucose F18</subject><subject>Gallium Radioisotopes</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Heterocyclic Compounds, 1-Ring - chemistry</subject><subject>Humans</subject><subject>Imaging</subject><subject>Inflammation - diagnostic imaging</subject><subject>Inflammation - metabolism</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - diagnostic imaging</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Peptides - chemistry</subject><subject>Peptides - metabolism</subject><subject>Positron-Emission Tomography</subject><subject>Proteins</subject><subject>Radiology</subject><subject>Rats</subject><subject>Rodents</subject><subject>Skin Diseases - diagnostic imaging</subject><subject>Skin Diseases - metabolism</subject><subject>Tomography</subject><subject>Tumors</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc9u1DAQxiMEov94AC7I4m4YezeOzW3VdrdIlbqHpddoYjupq40TbAe6L9LnxdGWcuI0M_Lv-8aaryg-MvjCAKqvEYCXigIDypaqooc3xSkTTNEKpHr72ldwUpzF-AjAJJfqfXHCoeQLJeVp8by93hHXY-d8R4aWON_use8xucET9IagsX7QGLTzQ4_kKU9dwDZFMsVZ8wujnvYYMvhg46waw5Cs84SRhKGzaaZGOyZnLBFyg_Tqbre6X23pln0jeuhHDC5m3W-XHgiTa7q-2lwU71rcR_vhpZ4XP9bXu8sbenu3-X65uqV6AZBoxZleWtYaKNFgiwtTykaA4i3IplKK80ZzhuUSGyOt4cw0pSgFCmOFbtAuzovPR9_86Z-Tjal-HKbg88q6KoELqZjIEDtCOgwxBtvWY8gnC4eaQT0HUR-DqGGecxD1IWs-vRhPTW_Nq-Lv5TPAj0DMT76z4d_m_7v-AWDKlUs</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Autio, Anu</creator><creator>Ujula, Tiina</creator><creator>Luoto, Pauliina</creator><creator>Salomäki, Satu</creator><creator>Jalkanen, Sirpa</creator><creator>Roivainen, Anne</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20101001</creationdate><title>PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG</title><author>Autio, Anu ; Ujula, Tiina ; Luoto, Pauliina ; Salomäki, Satu ; Jalkanen, Sirpa ; Roivainen, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-721c4e1fd05adafa3d58b6092f08b79922bc21a54abd8ed21db5656a6de6cbae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Amine Oxidase (Copper-Containing) - metabolism</topic><topic>Animals</topic><topic>Cardiology</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Transformation, Neoplastic</topic><topic>Fluorodeoxyglucose F18</topic><topic>Gallium Radioisotopes</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Heterocyclic Compounds, 1-Ring - chemistry</topic><topic>Humans</topic><topic>Imaging</topic><topic>Inflammation - diagnostic imaging</topic><topic>Inflammation - metabolism</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - diagnostic imaging</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Peptides - chemistry</topic><topic>Peptides - metabolism</topic><topic>Positron-Emission Tomography</topic><topic>Proteins</topic><topic>Radiology</topic><topic>Rats</topic><topic>Rodents</topic><topic>Skin Diseases - diagnostic imaging</topic><topic>Skin Diseases - metabolism</topic><topic>Tomography</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Autio, Anu</creatorcontrib><creatorcontrib>Ujula, Tiina</creatorcontrib><creatorcontrib>Luoto, Pauliina</creatorcontrib><creatorcontrib>Salomäki, Satu</creatorcontrib><creatorcontrib>Jalkanen, Sirpa</creatorcontrib><creatorcontrib>Roivainen, Anne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Autio, Anu</au><au>Ujula, Tiina</au><au>Luoto, Pauliina</au><au>Salomäki, Satu</au><au>Jalkanen, Sirpa</au><au>Roivainen, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>37</volume><issue>10</issue><spage>1918</spage><epage>1925</epage><pages>1918-1925</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
The aim of this study was to evaluate inflammation and tumour imaging with a vascular adhesion protein 1 (VAP-1) targeting peptide
68
Ga-DOTAVAP-P1 in comparison with
18
F-FDG.
Methods
Rats with both subcutaneous human pancreatic adenocarcinoma xenografts and turpentine oil-induced acute sterile inflammation were evaluated by dynamic positron emission tomography (PET) and by digital autoradiography of tissue cryosections. Subsequently, the autoradiographs were combined with histological and immunohistological analysis of the sections.
Results
68
Ga-DOTAVAP-P1 delineated acute, sterile inflammation comparable with
18
F-FDG. However, the tumour uptake of
68
Ga-DOTAVAP-P1 was low in contrast to prominent
18
F-FDG uptake. The standardised uptake values of inflammation and tumours by PET were 1.1 ± 0.4 (mean ± SEM) and 0.4 ± 0.1 for
68
Ga-DOTAVAP-P1 and 2.0 ± 0.5 and 1.6 ± 0.8 for
18
F-FDG, respectively. In addition, PET studies showed inflammation to muscle and tumour to muscle ratios of 5.1 ± 3.1 and 1.7 ± 0.3 for
68
Ga-DOTAVAP-P1 and 6.2 ± 0.7 and 4.6 ± 2.2 for
18
F-FDG, respectively. Immunohistochemistry revealed increased expression of luminal VAP-1 on the endothelium at the site of inflammation and low expression in the tumour
Conclusion
The
68
Ga-DOTAVAP-P1 PET was able to visualise inflammation better than tumour, which was in accordance with the luminal expression of VAP-1 on vasculature in these experimental models.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20523988</pmid><doi>10.1007/s00259-010-1497-y</doi><tpages>8</tpages></addata></record> |
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| issn | 1619-7070 1619-7089 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Amine Oxidase (Copper-Containing) - metabolism Animals Cardiology Cell Adhesion Molecules - metabolism Cell Line, Tumor Cell Transformation, Neoplastic Fluorodeoxyglucose F18 Gallium Radioisotopes Gene Expression Regulation, Neoplastic Heterocyclic Compounds, 1-Ring - chemistry Humans Imaging Inflammation - diagnostic imaging Inflammation - metabolism Male Medicine Medicine & Public Health Nuclear Medicine Oncology Original Article Orthopedics Pancreatic cancer Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Peptides - chemistry Peptides - metabolism Positron-Emission Tomography Proteins Radiology Rats Rodents Skin Diseases - diagnostic imaging Skin Diseases - metabolism Tomography Tumors |
| title | PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG |
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