A Toxic Combination
Zeineh examines the case of 73-year-old man with a known history of chronic obstructive pulmonary disease. He was promptly intubated by the emergency department physicians, placed on mechanical ventilation, and given intravenous levofloxacin and corticosteroids. He was transferred to the medical int...
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| Veröffentlicht in: | The American journal of medicine 2010-08, Vol.123 (8), p.707-708 |
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| container_title | The American journal of medicine |
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| creator | Zeineh, Nabil S., MD |
| description | Zeineh examines the case of 73-year-old man with a known history of chronic obstructive pulmonary disease. He was promptly intubated by the emergency department physicians, placed on mechanical ventilation, and given intravenous levofloxacin and corticosteroids. He was transferred to the medical intensive care unit for management. An electrocardiogram (ECG) taken at admission showed signs of left ventricular hypertrophy and a QT interval corrected for heart rate of 450 msec. The patient's ECG changes and arrhythmia were multifactorial in etiology. Specifically, the diagnosis was levofloxacin-induced QT prolongation in the context of severe left ventricular dysfunction and chronic amiodarone therapy. The administration of levofloxacin in combination with amiodarone therapy precipitated the patient's ECG changes and arrhythmia. |
| doi_str_mv | 10.1016/j.amjmed.2010.03.002 |
| format | Article |
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| ispartof | The American journal of medicine, 2010-08, Vol.123 (8), p.707-708 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aged Amiodarone - therapeutic use Anti-Arrhythmia Agents - therapeutic use Anti-Bacterial Agents - adverse effects Biological and medical sciences Cardiac arrhythmia Chronic obstructive pulmonary disease Drug Therapy, Combination - adverse effects Electrocardiography General aspects Heart Conduction System - drug effects Humans Internal Medicine Male Medical sciences Myocardial Ischemia - complications Ofloxacin - adverse effects Pulmonary Disease, Chronic Obstructive - complications Torsades de Pointes - complications |
| title | A Toxic Combination |
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