Association of rare MSH6 variants with familial breast cancer

Germline mutations in the mismatch repair genes MLH1, MSH2, MSH6, and PMS2 predispose to Lynch syndrome (also known as hereditary non-polyposis colorectal cancer). Recently, we have shown that the CHEK2 1100delC mutation also is associated with Lynch syndrome/Lynch syndrome-associated families albei...

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Veröffentlicht in:	Breast cancer research and treatment 2010-09, Vol.123 (2), p.315-320
Hauptverfasser:	Wasielewski, Marijke, Riaz, Muhammad, Vermeulen, Joyce, van den Ouweland, Ans, Labrijn-Marks, Ineke, Olmer, Renske, van der Spaa, Linda, Klijn, Jan G. M, Meijers-Heijboer, Hanne, Dooijes, Dennis, Schutte, Mieke
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - genetics Cancer research Case-Control Studies CHEK2 1100delC Colorectal cancer DNA Mutational Analysis DNA-Binding Proteins - genetics Exons Familial breast cancer Female Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Gene mutations Genes Genetic aspects Genetic disorders Genetic Predisposition to Disease Gynecology. Andrology. Obstetrics Hereditary breast and colorectal cancer Humans Incidence Introns Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged MSH6 Multifactorial Inheritance Mutation Netherlands - epidemiology Oncology Pedigree Phenotype Polygenic cancer susceptibility Preclinical Study Risk Assessment Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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