Epigenetic downregulation of human disabled homolog 2 switches TGF-[Beta] from a tumor suppressor to a tumor promoter

The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine as a potent oncogenic factor; however, the mechanistic basis for this is po...

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Veröffentlicht in:	The Journal of clinical investigation 2010-08, Vol.120 (8), p.2842
Hauptverfasser:	Hannigan, Adèle, Smith, Paul, Kalna, Gabriela, Lo Nigro, Cristiana, Orange, Clare, O'Brien, Darren I, Shah, Reshma, Syed, Nelofer, Spender, Lindsay C, Herrera, Blanca, Thurlow, Johanna K, Lattanzio, Laura, Monteverde, Martino, Maurer, Meghan E, Buffa, Francesca M, Mann, Jelena, Chu, David C K, West, Catharine M L, Patridge, Max, Oien, Karin A, Cooper, Jonathan A, Frame, Margaret C, Harris, Adrian L, Hiller, Louise, Nicholson, Linda J, Gasco, Milena, Crook, Tim, Inman, Gareth J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Biomarkers Biomedical research Cancer Cell growth Cytokines Epigenetics Gene expression Genomes Kinases Medical prognosis Metastasis Motility Phosphorylation Tumorigenesis
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