Leakiness and Size Exclusion of Paracellular Channels in Cultured Epithelial Cell Monolayers-Interlaboratory Comparison

Purpose To determine and compare the paracellular characteristics of permeability (Papp) of Caco-2, MDCK, and 2/4/A1 cell lines. Methods The Papp data from 14 studies were analyzed by weighted nonlinear regression in terms of the paracellular parameters: porosity-pathlength (ε/δ), pore radius (R), a...

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Veröffentlicht in:	Pharmaceutical research 2010-03, Vol.27 (3), p.480-489
1. Verfasser:	Avdeef, Alex
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Caco-2 Cells Cell Line Cell Membrane Permeability Diffusion Epithelial Cells - metabolism General pharmacology Humans Medical Law Medical sciences Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Research Paper
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