Novel chimeric anti-ricin antibody C4C13 with neutralizing activity against ricin toxicity

So far, no specific therapeutic agent is available for the treatment of ricin intoxication. Here, VH and VL genes were cloned from a hybridoma cell line secreting anti-ricin mAb 4C13, which could neutralize the toxicity of ricin. A chimeric antibody, c4C13, containing 4C13 mAb variable region genes...

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Veröffentlicht in:	Biotechnology letters 2007-12, Vol.29 (12), p.1811-1816
Hauptverfasser:	Wang, Yugang, Guo, Leiming, Zhao, Kunpeng, Chen, Jugao, Feng, Jiannan, Sun, Yingxun, Li, Yan, Shen, Beifen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibody Specificity - drug effects Base Sequence Binding Sites, Antibody Binding, Competitive - drug effects Biological and medical sciences Biotechnology Blotting, Western Cell Death - drug effects Chimeric antibody Cytotoxicity Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Humans Immunoglobulin Variable Region - chemistry Jurkat Cells Molecular Sequence Data Neutralization Tests Neutralizing activity Recombinant Proteins - chemistry Recombinant Proteins - immunology ricin Ricin - immunology Ricin - toxicity Rodents toxicity
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