1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin [beta], a substrate of parkin, and reduces its polyubiquitination

Substances that mimic the actions of causative gene products of familial Parkinson's disease (PD) are candidate as causative agents of idiopathic PD. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, is present at three times higher levels in CSF of PD patients than in...

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Veröffentlicht in:	Journal of neurochemistry 2010-09, Vol.114 (5), p.1291
Hauptverfasser:	Kohta, Ryuki, Kotake, Yaichiro, Hosoya, Takamitsu, Hiramatsu, Toshiyuki, Otsubo, Yuko, Koyama, Hiroko, Hirokane, Yuji, Yokoyama, Yuichi, Ikeshoji, Hirofumi, Oofusa, Ken, Suzuki, Masaaki, Ohta, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Genetics Neurology Parkinson's disease Proteins
Online-Zugang:	Volltext
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