The Most Predominant Spoligopatterns of Mycobacterium tuberculosis Isolates among Iranian, Afghan-Immigrant, Pakistani and Turkish Tuberculosis Patients: A Comparative Analysis

Background: The aim of this study was to identify prevalent spoligopatterns of Mycobacterium tuberculosis (MTB) strains within Iran and its neighboring countries. Methods: The spacer oligonucleotide typing (spoligotyping) was performed on 1,742 MTB strains isolated from Iranian and Afghan patients....

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Veröffentlicht in:Chemotherapy (Basel) 2010-01, Vol.56 (3), p.248-257
Hauptverfasser: Merza, Muayad A., Farnia, Parissa, Salih, Ahmad M., Masjedi, Mohammad Reza, Velayati, Ali Akbar
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container_start_page 248
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creator Merza, Muayad A.
Farnia, Parissa
Salih, Ahmad M.
Masjedi, Mohammad Reza
Velayati, Ali Akbar
description Background: The aim of this study was to identify prevalent spoligopatterns of Mycobacterium tuberculosis (MTB) strains within Iran and its neighboring countries. Methods: The spacer oligonucleotide typing (spoligotyping) was performed on 1,742 MTB strains isolated from Iranian and Afghan patients. Subsequently, these results were compared with published results of Pakistan and Turkey. Results: Based on the international spoligotyping database T, Central Asian Strain (CAS), East African-Indian and Latin American and Mediterranean families were prevalent in the region. T was dominant amongIranian (32.3%) and Turkish (36.5%), whereas CAS was more prevalent among Pakistani (61.3%) and Afghan-immigrant (27.4%) TB patients. Conclusion: The majority of strains isolated from Pakistan and Afghanistan belonged to ancient MTB genotypes (principal genetic group, PGG, I). In contrast, in Turkey there was prevalence of modern TB (PGG II and III), whereas in Iran, the prevalence of ancient and modern TB was almost equal. Therefore, Iran may be considered as the connecting geographical location between ancient and modern TB.
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Methods: The spacer oligonucleotide typing (spoligotyping) was performed on 1,742 MTB strains isolated from Iranian and Afghan patients. Subsequently, these results were compared with published results of Pakistan and Turkey. Results: Based on the international spoligotyping database T, Central Asian Strain (CAS), East African-Indian and Latin American and Mediterranean families were prevalent in the region. T was dominant amongIranian (32.3%) and Turkish (36.5%), whereas CAS was more prevalent among Pakistani (61.3%) and Afghan-immigrant (27.4%) TB patients. Conclusion: The majority of strains isolated from Pakistan and Afghanistan belonged to ancient MTB genotypes (principal genetic group, PGG, I). In contrast, in Turkey there was prevalence of modern TB (PGG II and III), whereas in Iran, the prevalence of ancient and modern TB was almost equal. 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Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-b59a50a689f1f5a27962aaad6979879d9f8a1ee8bd0c836fcb37c032a43ac8973</citedby><cites>FETCH-LOGICAL-c364t-b59a50a689f1f5a27962aaad6979879d9f8a1ee8bd0c836fcb37c032a43ac8973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,2425,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20551642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merza, Muayad A.</creatorcontrib><creatorcontrib>Farnia, Parissa</creatorcontrib><creatorcontrib>Salih, Ahmad M.</creatorcontrib><creatorcontrib>Masjedi, Mohammad Reza</creatorcontrib><creatorcontrib>Velayati, Ali Akbar</creatorcontrib><title>The Most Predominant Spoligopatterns of Mycobacterium tuberculosis Isolates among Iranian, Afghan-Immigrant, Pakistani and Turkish Tuberculosis Patients: A Comparative Analysis</title><title>Chemotherapy (Basel)</title><addtitle>Chemotherapy</addtitle><description>Background: The aim of this study was to identify prevalent spoligopatterns of Mycobacterium tuberculosis (MTB) strains within Iran and its neighboring countries. 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Methods: The spacer oligonucleotide typing (spoligotyping) was performed on 1,742 MTB strains isolated from Iranian and Afghan patients. Subsequently, these results were compared with published results of Pakistan and Turkey. Results: Based on the international spoligotyping database T, Central Asian Strain (CAS), East African-Indian and Latin American and Mediterranean families were prevalent in the region. T was dominant amongIranian (32.3%) and Turkish (36.5%), whereas CAS was more prevalent among Pakistani (61.3%) and Afghan-immigrant (27.4%) TB patients. Conclusion: The majority of strains isolated from Pakistan and Afghanistan belonged to ancient MTB genotypes (principal genetic group, PGG, I). In contrast, in Turkey there was prevalence of modern TB (PGG II and III), whereas in Iran, the prevalence of ancient and modern TB was almost equal. 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subjects Adult
Afghanistan - epidemiology
DNA, Intergenic - genetics
Emigrants and Immigrants
Epidemiology
Female
Genetic diversity
Genotype & phenotype
Humans
Iran - epidemiology
Male
Microbiology
Middle Aged
Minority & ethnic groups
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Noncitizens
Oligonucleotide Array Sequence Analysis - methods
Oligonucleotides - genetics
Pakistan - epidemiology
Tuberculosis
Tuberculosis - epidemiology
Tuberculosis - genetics
Turkey - epidemiology
title The Most Predominant Spoligopatterns of Mycobacterium tuberculosis Isolates among Iranian, Afghan-Immigrant, Pakistani and Turkish Tuberculosis Patients: A Comparative Analysis
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