Intralesional Ethibloc injections in primary aneurysmal bone cysts: an efficient and safe treatment
Ethibloc is a fibrogenic and thrombogenic agent recently proposed for the treatment of bone cysts. The purpose of this study is to report the results of direct Ethibloc injection in primary aneurysmal bone cyst (ABC) in children. Seventeen patients, aged from 2 to 18 years (mean 8 years), were treat...
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| Veröffentlicht in: | Skeletal radiology 2003-10, Vol.32 (10), p.559-566 |
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| creator | ADAMSBAUM, C MASCARD, E GUINEBRETIERE, J. M KALIFA, G DUBOUSSET, J |
| description | Ethibloc is a fibrogenic and thrombogenic agent recently proposed for the treatment of bone cysts. The purpose of this study is to report the results of direct Ethibloc injection in primary aneurysmal bone cyst (ABC) in children.
Seventeen patients, aged from 2 to 18 years (mean 8 years), were treated with either a single injection (14 patients) or supplementary injections (3 patients) of Ethibloc. The histological diagnosis was assessed following surgical biopsy and was retrospectively reviewed. The mean follow-up was 5 years (range 18 months to 11 years).
At 5 year follow-up, 14 of 17 patients demonstrated complete healing manifest by increased cortical and septal thickening. Surgical excision was required in three patients, in two of whom the ABC increased rapidly in size despite the injection, and in one of whom the healing was incomplete. We observed inflammatory reactions in 16 of 17 patients with local pain and fever. Three patients developed a small cutaneous fistula which resolved spontaneously in a few weeks. No major complications such as deep infection, pulmonary embolism, epiphyseal necrosis or malignant degeneration were observed.
Percutaneous direct Ethibloc injection is a safe, efficient and noninvasive treatment for ABC. The authors highlight the frequent local reactions. |
| doi_str_mv | 10.1007/s00256-003-0653-x |
| format | Article |
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Seventeen patients, aged from 2 to 18 years (mean 8 years), were treated with either a single injection (14 patients) or supplementary injections (3 patients) of Ethibloc. The histological diagnosis was assessed following surgical biopsy and was retrospectively reviewed. The mean follow-up was 5 years (range 18 months to 11 years).
At 5 year follow-up, 14 of 17 patients demonstrated complete healing manifest by increased cortical and septal thickening. Surgical excision was required in three patients, in two of whom the ABC increased rapidly in size despite the injection, and in one of whom the healing was incomplete. We observed inflammatory reactions in 16 of 17 patients with local pain and fever. Three patients developed a small cutaneous fistula which resolved spontaneously in a few weeks. No major complications such as deep infection, pulmonary embolism, epiphyseal necrosis or malignant degeneration were observed.
Percutaneous direct Ethibloc injection is a safe, efficient and noninvasive treatment for ABC. The authors highlight the frequent local reactions.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s00256-003-0653-x</identifier><identifier>PMID: 12856159</identifier><identifier>CODEN: SKRADI</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Biological and medical sciences ; Bone Cysts, Aneurysmal - diagnostic imaging ; Bone Cysts, Aneurysmal - drug therapy ; Bone Cysts, Aneurysmal - pathology ; Bone Regeneration - drug effects ; Child ; Child, Preschool ; Cysts ; Diatrizoate - administration & dosage ; Diatrizoate - adverse effects ; Diseases of the osteoarticular system ; Drug Combinations ; Fatty Acids - administration & dosage ; Fatty Acids - adverse effects ; Female ; Follow-Up Studies ; Humans ; Injections, Intralesional ; Male ; Medical sciences ; Propylene Glycols - administration & dosage ; Propylene Glycols - adverse effects ; Radiography ; Retrospective Studies ; Sclerosing Solutions - administration & dosage ; Sclerosing Solutions - adverse effects ; Time Factors ; Treatment Outcome ; Tumors of striated muscle and skeleton ; Zein - administration & dosage ; Zein - adverse effects</subject><ispartof>Skeletal radiology, 2003-10, Vol.32 (10), p.559-566</ispartof><rights>2004 INIST-CNRS</rights><rights>ISS 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-c5d78fefa291e15a079db65ae1a4dd1b2733851d2e684deba3a49084bd128cd43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15160036$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12856159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ADAMSBAUM, C</creatorcontrib><creatorcontrib>MASCARD, E</creatorcontrib><creatorcontrib>GUINEBRETIERE, J. M</creatorcontrib><creatorcontrib>KALIFA, G</creatorcontrib><creatorcontrib>DUBOUSSET, J</creatorcontrib><title>Intralesional Ethibloc injections in primary aneurysmal bone cysts: an efficient and safe treatment</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><description>Ethibloc is a fibrogenic and thrombogenic agent recently proposed for the treatment of bone cysts. The purpose of this study is to report the results of direct Ethibloc injection in primary aneurysmal bone cyst (ABC) in children.
Seventeen patients, aged from 2 to 18 years (mean 8 years), were treated with either a single injection (14 patients) or supplementary injections (3 patients) of Ethibloc. The histological diagnosis was assessed following surgical biopsy and was retrospectively reviewed. The mean follow-up was 5 years (range 18 months to 11 years).
At 5 year follow-up, 14 of 17 patients demonstrated complete healing manifest by increased cortical and septal thickening. Surgical excision was required in three patients, in two of whom the ABC increased rapidly in size despite the injection, and in one of whom the healing was incomplete. We observed inflammatory reactions in 16 of 17 patients with local pain and fever. Three patients developed a small cutaneous fistula which resolved spontaneously in a few weeks. No major complications such as deep infection, pulmonary embolism, epiphyseal necrosis or malignant degeneration were observed.
Percutaneous direct Ethibloc injection is a safe, efficient and noninvasive treatment for ABC. The authors highlight the frequent local reactions.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Bone Cysts, Aneurysmal - diagnostic imaging</subject><subject>Bone Cysts, Aneurysmal - drug therapy</subject><subject>Bone Cysts, Aneurysmal - pathology</subject><subject>Bone Regeneration - drug effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cysts</subject><subject>Diatrizoate - administration & dosage</subject><subject>Diatrizoate - adverse effects</subject><subject>Diseases of the osteoarticular system</subject><subject>Drug Combinations</subject><subject>Fatty Acids - administration & dosage</subject><subject>Fatty Acids - adverse effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Injections, Intralesional</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Propylene Glycols - administration & dosage</subject><subject>Propylene Glycols - adverse effects</subject><subject>Radiography</subject><subject>Retrospective Studies</subject><subject>Sclerosing Solutions - administration & dosage</subject><subject>Sclerosing Solutions - adverse effects</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tumors of striated muscle and skeleton</subject><subject>Zein - administration & dosage</subject><subject>Zein - adverse effects</subject><issn>0364-2348</issn><issn>1432-2161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpFkEtLAzEUhYMotlZ_gBsJgsvRvGfGnZSqhYIbXYdMcgenzKMmGWj_vSkd6Oree_jugXMQuqfkmRKSvwRCmFQZITwjSvJsf4HmVHCWMaroJZoTrkTGuChm6CaELSE0z6W6RjPKCqmoLOfIrvvoTQuhGXrT4lX8bap2sLjpt2BjEkNa8c43nfEHbHoY_SF0iayGHrA9hBhek4yhrhvbQB_T4XAwNeDowcQuSbfoqjZtgLtpLtDP--p7-Zltvj7Wy7dNZrkUMbPS5UUNtWElBSoNyUtXKWmAGuEcrVjOeSGpY6AK4aAy3IiSFKJyKY51gi_Q48l354e_EULU22H0KVbQKawQXJUkQfQEWT-E4KHWUzhNiT62qk-t6tSqPraq9-nnYTIeqw7c-WOqMQFPE2CCNW3tTW-bcOYkVclO8X_HrIE5</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>ADAMSBAUM, C</creator><creator>MASCARD, E</creator><creator>GUINEBRETIERE, J. M</creator><creator>KALIFA, G</creator><creator>DUBOUSSET, J</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20031001</creationdate><title>Intralesional Ethibloc injections in primary aneurysmal bone cysts: an efficient and safe treatment</title><author>ADAMSBAUM, C ; MASCARD, E ; GUINEBRETIERE, J. M ; KALIFA, G ; DUBOUSSET, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-c5d78fefa291e15a079db65ae1a4dd1b2733851d2e684deba3a49084bd128cd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Bone Cysts, Aneurysmal - diagnostic imaging</topic><topic>Bone Cysts, Aneurysmal - drug therapy</topic><topic>Bone Cysts, Aneurysmal - pathology</topic><topic>Bone Regeneration - drug effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cysts</topic><topic>Diatrizoate - administration & dosage</topic><topic>Diatrizoate - adverse effects</topic><topic>Diseases of the osteoarticular system</topic><topic>Drug Combinations</topic><topic>Fatty Acids - administration & dosage</topic><topic>Fatty Acids - adverse effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Injections, Intralesional</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Propylene Glycols - administration & dosage</topic><topic>Propylene Glycols - adverse effects</topic><topic>Radiography</topic><topic>Retrospective Studies</topic><topic>Sclerosing Solutions - administration & dosage</topic><topic>Sclerosing Solutions - adverse effects</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tumors of striated muscle and skeleton</topic><topic>Zein - administration & dosage</topic><topic>Zein - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ADAMSBAUM, C</creatorcontrib><creatorcontrib>MASCARD, E</creatorcontrib><creatorcontrib>GUINEBRETIERE, J. 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M</au><au>KALIFA, G</au><au>DUBOUSSET, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intralesional Ethibloc injections in primary aneurysmal bone cysts: an efficient and safe treatment</atitle><jtitle>Skeletal radiology</jtitle><addtitle>Skeletal Radiol</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>32</volume><issue>10</issue><spage>559</spage><epage>566</epage><pages>559-566</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><coden>SKRADI</coden><abstract>Ethibloc is a fibrogenic and thrombogenic agent recently proposed for the treatment of bone cysts. The purpose of this study is to report the results of direct Ethibloc injection in primary aneurysmal bone cyst (ABC) in children.
Seventeen patients, aged from 2 to 18 years (mean 8 years), were treated with either a single injection (14 patients) or supplementary injections (3 patients) of Ethibloc. The histological diagnosis was assessed following surgical biopsy and was retrospectively reviewed. The mean follow-up was 5 years (range 18 months to 11 years).
At 5 year follow-up, 14 of 17 patients demonstrated complete healing manifest by increased cortical and septal thickening. Surgical excision was required in three patients, in two of whom the ABC increased rapidly in size despite the injection, and in one of whom the healing was incomplete. We observed inflammatory reactions in 16 of 17 patients with local pain and fever. Three patients developed a small cutaneous fistula which resolved spontaneously in a few weeks. No major complications such as deep infection, pulmonary embolism, epiphyseal necrosis or malignant degeneration were observed.
Percutaneous direct Ethibloc injection is a safe, efficient and noninvasive treatment for ABC. The authors highlight the frequent local reactions.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12856159</pmid><doi>10.1007/s00256-003-0653-x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Bone Cysts, Aneurysmal - diagnostic imaging Bone Cysts, Aneurysmal - drug therapy Bone Cysts, Aneurysmal - pathology Bone Regeneration - drug effects Child Child, Preschool Cysts Diatrizoate - administration & dosage Diatrizoate - adverse effects Diseases of the osteoarticular system Drug Combinations Fatty Acids - administration & dosage Fatty Acids - adverse effects Female Follow-Up Studies Humans Injections, Intralesional Male Medical sciences Propylene Glycols - administration & dosage Propylene Glycols - adverse effects Radiography Retrospective Studies Sclerosing Solutions - administration & dosage Sclerosing Solutions - adverse effects Time Factors Treatment Outcome Tumors of striated muscle and skeleton Zein - administration & dosage Zein - adverse effects |
| title | Intralesional Ethibloc injections in primary aneurysmal bone cysts: an efficient and safe treatment |
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