7-Nitroindazole Attenuates 6-Hydroxydopamine-Induced Spatial Learning Deficits and Dopamine Neuron Loss in a Presymptomatic Animal Model of Parkinson's Disease

Parkinson's disease (PD) is a neurodegenerative disorder in which loss of dopaminergic (DA) neurons (>50%) in the substantia nigra (SN) precede most of the overt motor symptoms, making early diagnosis and treatment interventions difficult. Because PD has been associated with free radicals ge...

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Veröffentlicht in:	Experimental and clinical psychopharmacology 2008-04, Vol.16 (2), p.178-189
Hauptverfasser:	Haik, Kristi L, Shear, Deborah A, Hargrove, Chad, Patton, Jared, Mazei-Robison, Michelle, Sandstrom, Michael I, Dunbar, Gary L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animal Animal Models Animals Behavior, Animal - drug effects Disease Models, Animal Dopamine Dopamine - metabolism Indazoles - therapeutic use Learning Disorders - chemically induced Learning Disorders - drug therapy Learning Disorders - pathology Male Maze Learning - drug effects NADP - metabolism Neurons - drug effects Neurons - metabolism Neuroprotective Agents - therapeutic use Oxidopamine Parkinson Disease - drug therapy Parkinson's Disease Psychomotor Performance - drug effects Rats Rats, Sprague-Dawley Spatial Behavior - drug effects Spatial Behavior - physiology Spatial Learning Substantia Nigra - pathology
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