Adverse Effects of Gabapentin and Lack of Anti-Allodynic Efficacy of Amitriptyline in the Streptozotocin Model of Painful Diabetic Neuropathy

Amitriptyline and gabapentin are the primary treatments for painful diabetic neuropathy (PDN), and it is clear that they produce beneficial effects, but there are questions about these treatments that have not been adequately addressed. For example, although there is a growing consensus that the the...

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Veröffentlicht in:	Experimental and clinical psychopharmacology 2006-02, Vol.14 (1), p.42-51
Hauptverfasser:	Lindner, Mark D, Bourin, Clotilde, Chen, Ping, McElroy, John F, Leet, John E, Hogan, John B, Stock, David A, Machet, Frederic
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - adverse effects Amines - therapeutic use Amitriptyline Amitriptyline - pharmacology Amitriptyline - therapeutic use Animal Animal Models Animals Anticonvulsive Drugs Cognition Disorders - chemically induced Cognitive Impairment Cyclohexanecarboxylic Acids - adverse effects Cyclohexanecarboxylic Acids - therapeutic use Diabetes Diabetes Mellitus, Experimental - complications Diabetic Neuropathies - drug therapy Dose-Response Relationship, Drug Drug Therapy Drugs Gabapentin gamma-Aminobutyric Acid - adverse effects gamma-Aminobutyric Acid - therapeutic use Male Maze Learning - drug effects Motor Processes Nervous System Disorders Neuropathy Pain Perception Rats Rats, Sprague-Dawley Reaction Time - drug effects Side Effects (Drug) Streptozocin
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