Response Shifting and Inhibition, but Not Working Memory, Are Impaired After Long-Term Heavy Alcohol Consumption
Chronic alcohol abuse leads to cognitive deficits. The authors investigated whether a systematic increase of interference in a 2-back working memory paradigm would lead to cognitive deficits in alcoholic participants and compared their performance in such a task with that in an alternate-response ta...
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| Veröffentlicht in: | Neuropsychology 2004-04, Vol.18 (2), p.203-211 |
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| creator | Hildebrandt, Helmut Brokate, Barbara Eling, Paul Lanz, Michael |
| description | Chronic alcohol abuse leads to cognitive deficits. The authors investigated whether a systematic increase of interference in a 2-back working memory paradigm would lead to cognitive deficits in alcoholic participants and compared their performance in such a task with that in an alternate-response task. Twenty-four nonamnesic and nondemented alcohol abuse (AA) patients and 12 patients with Korsakoff's syndrome (KS) were compared with a control group. AA patients were impaired in the alternate-response task but not in working memory interference resolution. KS patients performed worse than the AA patients and the controls in both tasks. The neurotoxic side effects of alcohol therefore lead to a specific deficit in alternating between response rules but not in working memory, independently of whether the working memory task involves interference resolution or not. |
| doi_str_mv | 10.1037/0894-4105.18.2.203 |
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The authors investigated whether a systematic increase of interference in a 2-back working memory paradigm would lead to cognitive deficits in alcoholic participants and compared their performance in such a task with that in an alternate-response task. Twenty-four nonamnesic and nondemented alcohol abuse (AA) patients and 12 patients with Korsakoff's syndrome (KS) were compared with a control group. AA patients were impaired in the alternate-response task but not in working memory interference resolution. KS patients performed worse than the AA patients and the controls in both tasks. The neurotoxic side effects of alcohol therefore lead to a specific deficit in alternating between response rules but not in working memory, independently of whether the working memory task involves interference resolution or not.</description><identifier>ISSN: 0894-4105</identifier><identifier>EISSN: 1931-1559</identifier><identifier>DOI: 10.1037/0894-4105.18.2.203</identifier><identifier>PMID: 15099142</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Adult ; Adult and adolescent clinical studies ; Alcohol Abuse ; Alcohol Amnestic Disorder - diagnosis ; Alcohol Amnestic Disorder - psychology ; Alcohol Amnestic Disorder - rehabilitation ; Alcoholism ; Alcoholism - psychology ; Alcoholism - rehabilitation ; Attention - drug effects ; Biological and medical sciences ; Cognitive Impairment ; Discrimination Learning - drug effects ; Ethanol - toxicity ; Female ; Human ; Humans ; Inhibition (Psychology) ; Interference (Learning) ; Korsakoff Syndrome ; Latent Inhibition ; Male ; Medical sciences ; Memory, Short-Term - drug effects ; Mental Recall - drug effects ; Middle Aged ; Organic mental disorders. Neuropsychology ; Pattern Recognition, Visual - drug effects ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance - drug effects ; Psychopathology. 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The authors investigated whether a systematic increase of interference in a 2-back working memory paradigm would lead to cognitive deficits in alcoholic participants and compared their performance in such a task with that in an alternate-response task. Twenty-four nonamnesic and nondemented alcohol abuse (AA) patients and 12 patients with Korsakoff's syndrome (KS) were compared with a control group. AA patients were impaired in the alternate-response task but not in working memory interference resolution. KS patients performed worse than the AA patients and the controls in both tasks. The neurotoxic side effects of alcohol therefore lead to a specific deficit in alternating between response rules but not in working memory, independently of whether the working memory task involves interference resolution or not.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Alcohol Abuse</subject><subject>Alcohol Amnestic Disorder - diagnosis</subject><subject>Alcohol Amnestic Disorder - psychology</subject><subject>Alcohol Amnestic Disorder - rehabilitation</subject><subject>Alcoholism</subject><subject>Alcoholism - psychology</subject><subject>Alcoholism - rehabilitation</subject><subject>Attention - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cognitive Impairment</subject><subject>Discrimination Learning - drug effects</subject><subject>Ethanol - toxicity</subject><subject>Female</subject><subject>Human</subject><subject>Humans</subject><subject>Inhibition (Psychology)</subject><subject>Interference (Learning)</subject><subject>Korsakoff Syndrome</subject><subject>Latent Inhibition</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory, Short-Term - drug effects</subject><subject>Mental Recall - drug effects</subject><subject>Middle Aged</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Pattern Recognition, Visual - drug effects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance - drug effects</subject><subject>Psychopathology. Psychiatry</subject><subject>Reaction Time - drug effects</subject><subject>Recognition (Psychology) - drug effects</subject><subject>Response Parameters</subject><subject>Serial Learning - drug effects</subject><subject>Short Term Memory</subject><issn>0894-4105</issn><issn>1931-1559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0F1rFDEUBuAgil2rf8ALCaJXdtYkk_nI5bKoXdgqaMXLkMmedFNnkjHJFPbfm2GXWqFXgZPnnBdehF5TsqSkbD6SVvCCU1ItabtkS0bKJ2hBRUkLWlXiKVrcgzP0IsZbQvKgrp6jM1oRIShnCzR-hzh6FwH_2FuTrLvByu3wxu1tZ5P17gJ3U8JffcK_fPg9_1_B4MPhAq8C4M0wKhtgh1cmQcBb726KawgDvgR1d8CrXvu97_E6J0zDON97iZ4Z1Ud4dXrP0c_Pn67Xl8X225fNerUtFGc0FU1DBFOUdC0TvCOsE6Ljgu1IXRFDmAajODQlmLppMqkZb1VtjM5Ck5Lq8hy9Pd4dg_8zQUzy1k_B5UhZU85ZVZdNRuyIdPAxBjByDHZQ4SApkXPHcq5QzhVK2komc8d56c3p8tQNsPu3cio1g_cnoKJWvQnKaRsfuLqsW06y-3B0alRyjAetQrK6h6inEMAl6WB6GPvucf0_-wudXZ8k</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Hildebrandt, Helmut</creator><creator>Brokate, Barbara</creator><creator>Eling, Paul</creator><creator>Lanz, Michael</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope></search><sort><creationdate>20040401</creationdate><title>Response Shifting and Inhibition, but Not Working Memory, Are Impaired After Long-Term Heavy Alcohol Consumption</title><author>Hildebrandt, Helmut ; Brokate, Barbara ; Eling, Paul ; Lanz, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a421t-77092a10b8294b02b99b492d0650f02cefa4e73ef6778296248a6ffc2d0c031c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Alcohol Abuse</topic><topic>Alcohol Amnestic Disorder - diagnosis</topic><topic>Alcohol Amnestic Disorder - psychology</topic><topic>Alcohol Amnestic Disorder - rehabilitation</topic><topic>Alcoholism</topic><topic>Alcoholism - psychology</topic><topic>Alcoholism - rehabilitation</topic><topic>Attention - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cognitive Impairment</topic><topic>Discrimination Learning - drug effects</topic><topic>Ethanol - toxicity</topic><topic>Female</topic><topic>Human</topic><topic>Humans</topic><topic>Inhibition (Psychology)</topic><topic>Interference (Learning)</topic><topic>Korsakoff Syndrome</topic><topic>Latent Inhibition</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory, Short-Term - drug effects</topic><topic>Mental Recall - drug effects</topic><topic>Middle Aged</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Pattern Recognition, Visual - drug effects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance - drug effects</topic><topic>Psychopathology. Psychiatry</topic><topic>Reaction Time - drug effects</topic><topic>Recognition (Psychology) - drug effects</topic><topic>Response Parameters</topic><topic>Serial Learning - drug effects</topic><topic>Short Term Memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hildebrandt, Helmut</creatorcontrib><creatorcontrib>Brokate, Barbara</creatorcontrib><creatorcontrib>Eling, Paul</creatorcontrib><creatorcontrib>Lanz, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><jtitle>Neuropsychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hildebrandt, Helmut</au><au>Brokate, Barbara</au><au>Eling, Paul</au><au>Lanz, Michael</au><au>Becker, James T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response Shifting and Inhibition, but Not Working Memory, Are Impaired After Long-Term Heavy Alcohol Consumption</atitle><jtitle>Neuropsychology</jtitle><addtitle>Neuropsychology</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>18</volume><issue>2</issue><spage>203</spage><epage>211</epage><pages>203-211</pages><issn>0894-4105</issn><eissn>1931-1559</eissn><abstract>Chronic alcohol abuse leads to cognitive deficits. The authors investigated whether a systematic increase of interference in a 2-back working memory paradigm would lead to cognitive deficits in alcoholic participants and compared their performance in such a task with that in an alternate-response task. Twenty-four nonamnesic and nondemented alcohol abuse (AA) patients and 12 patients with Korsakoff's syndrome (KS) were compared with a control group. AA patients were impaired in the alternate-response task but not in working memory interference resolution. KS patients performed worse than the AA patients and the controls in both tasks. The neurotoxic side effects of alcohol therefore lead to a specific deficit in alternating between response rules but not in working memory, independently of whether the working memory task involves interference resolution or not.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>15099142</pmid><doi>10.1037/0894-4105.18.2.203</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Alcohol Abuse Alcohol Amnestic Disorder - diagnosis Alcohol Amnestic Disorder - psychology Alcohol Amnestic Disorder - rehabilitation Alcoholism Alcoholism - psychology Alcoholism - rehabilitation Attention - drug effects Biological and medical sciences Cognitive Impairment Discrimination Learning - drug effects Ethanol - toxicity Female Human Humans Inhibition (Psychology) Interference (Learning) Korsakoff Syndrome Latent Inhibition Male Medical sciences Memory, Short-Term - drug effects Mental Recall - drug effects Middle Aged Organic mental disorders. Neuropsychology Pattern Recognition, Visual - drug effects Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychopathology. Psychiatry Reaction Time - drug effects Recognition (Psychology) - drug effects Response Parameters Serial Learning - drug effects Short Term Memory |
| title | Response Shifting and Inhibition, but Not Working Memory, Are Impaired After Long-Term Heavy Alcohol Consumption |
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