Frontal Lobe Dysfunctions in Korsakoff's Syndrome and Chronic Alcoholism: Continuity or Discontinuity?
The effect of long-term heavy alcohol consumption on brain functions is still under debate. The authors investigated a sample of 17 Korsakoff amnesics, 23 alcoholics without Korsakoff's syndrome, and 21 controls with peripheral nerve diseases, matched for intelligence and education. Executive f...
Gespeichert in:
| Veröffentlicht in: | Neuropsychology 2003-07, Vol.17 (3), p.420-428 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 428 |
|---|---|
| container_issue | 3 |
| container_start_page | 420 |
| container_title | Neuropsychology |
| container_volume | 17 |
| creator | Brokate, B Hildebrandt, H Eling, P Fichtner, H Runge, K Timm, C |
| description | The effect of long-term heavy alcohol consumption on brain functions is still under debate. The authors investigated a sample of 17 Korsakoff amnesics, 23 alcoholics without Korsakoff's syndrome, and 21 controls with peripheral nerve diseases, matched for intelligence and education. Executive functions were examined for word fluency, the modified Wisconsin Card Sorting Test, an alternate response task, and an "n-back" working memory task. Korsakoff amnesics, but not alcoholics, showed a marked memory impairment. They also scored lower in each of the executive tasks-the alcoholics only in the alternate response task. This task also correlated with the years of the alcohol dependency. First, the authors conclude that Korsakoff's syndrome is associated not only with a memory impairment but also with a global executive deficit. Second, the decline in the ability to alternate between different responses argues for a restricted neurotoxic effect of alcohol on some frontal lobe areas. |
| doi_str_mv | 10.1037/0894-4105.17.3.420 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_614386043</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>614386043</sourcerecordid><originalsourceid>FETCH-LOGICAL-a475t-6e08da29156aaf6df0a2127d42d7ada40fd65ef5810e50872f863175dcd37b5b3</originalsourceid><addsrcrecordid>eNpt0MtqGzEUBmBRGmon6Qt0UYaSkEUYR3fNLIObGzFkkXQtjnXBk44lV5pZ-O0rY5O0kJXg8P3niB-hbwTPCGbqCjctrznBYkbUjM04xZ_QlLSM1ESI9jOavoEJOs75FeMykOILmhDailbgZorub1MMA_TVIi5d9XOb_RjM0MWQqy5UjzFl-B29v8jV8zbYFNeugmCr-arEOlNd9yauYt_l9Sk68tBn9_XwnqBftzcv8_t68XT3ML9e1MCVGGrpcGOBtkRIAC-tx0AJVZZTq8ACx95K4bxoCHblg4r6RjKihDWWqaVYshP0Y793k-Kf0eVBv8YxhXJSS8JZIzFnBdE9MinmnJzXm9StIW01wXrXnd5Vo3fVaKI006W7Evp-2Dwu186-Rw5lFXB-AJAN9D5BMF1-dwJLThUp7nLvYAN6k7cG0tCZ3mUzpuTCoIMb_z179rH-n_0FCZaR9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>614386043</pqid></control><display><type>article</type><title>Frontal Lobe Dysfunctions in Korsakoff's Syndrome and Chronic Alcoholism: Continuity or Discontinuity?</title><source>MEDLINE</source><source>APA PsycARTICLES</source><creator>Brokate, B ; Hildebrandt, H ; Eling, P ; Fichtner, H ; Runge, K ; Timm, C</creator><contributor>Becker, James T</contributor><creatorcontrib>Brokate, B ; Hildebrandt, H ; Eling, P ; Fichtner, H ; Runge, K ; Timm, C ; Becker, James T</creatorcontrib><description>The effect of long-term heavy alcohol consumption on brain functions is still under debate. The authors investigated a sample of 17 Korsakoff amnesics, 23 alcoholics without Korsakoff's syndrome, and 21 controls with peripheral nerve diseases, matched for intelligence and education. Executive functions were examined for word fluency, the modified Wisconsin Card Sorting Test, an alternate response task, and an "n-back" working memory task. Korsakoff amnesics, but not alcoholics, showed a marked memory impairment. They also scored lower in each of the executive tasks-the alcoholics only in the alternate response task. This task also correlated with the years of the alcohol dependency. First, the authors conclude that Korsakoff's syndrome is associated not only with a memory impairment but also with a global executive deficit. Second, the decline in the ability to alternate between different responses argues for a restricted neurotoxic effect of alcohol on some frontal lobe areas.</description><identifier>ISSN: 0894-4105</identifier><identifier>EISSN: 1931-1559</identifier><identifier>DOI: 10.1037/0894-4105.17.3.420</identifier><identifier>PMID: 12959508</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Addictive behaviors ; Adult ; Adult and adolescent clinical studies ; Aged ; Alcoholism ; Alcoholism - physiopathology ; Alcoholism - psychology ; Biological and medical sciences ; Case-Control Studies ; Cognitive Impairment ; Female ; Frontal Lobe ; Frontal Lobe - physiopathology ; Human ; Humans ; Inpatient ; Korsakoff Syndrome ; Korsakoff Syndrome - physiopathology ; Korsakoff Syndrome - psychology ; Male ; Medical sciences ; Memory Disorders - psychology ; Middle Aged ; Neuropathology ; Neuropsychological Tests ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance ; Psychopathology. Psychiatry ; Short Term Memory ; Verbal Learning</subject><ispartof>Neuropsychology, 2003-07, Vol.17 (3), p.420-428</ispartof><rights>2003 American Psychological Association</rights><rights>2003 INIST-CNRS</rights><rights>2003, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a475t-6e08da29156aaf6df0a2127d42d7ada40fd65ef5810e50872f863175dcd37b5b3</citedby><cites>FETCH-LOGICAL-a475t-6e08da29156aaf6df0a2127d42d7ada40fd65ef5810e50872f863175dcd37b5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15064271$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12959508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Becker, James T</contributor><creatorcontrib>Brokate, B</creatorcontrib><creatorcontrib>Hildebrandt, H</creatorcontrib><creatorcontrib>Eling, P</creatorcontrib><creatorcontrib>Fichtner, H</creatorcontrib><creatorcontrib>Runge, K</creatorcontrib><creatorcontrib>Timm, C</creatorcontrib><title>Frontal Lobe Dysfunctions in Korsakoff's Syndrome and Chronic Alcoholism: Continuity or Discontinuity?</title><title>Neuropsychology</title><addtitle>Neuropsychology</addtitle><description>The effect of long-term heavy alcohol consumption on brain functions is still under debate. The authors investigated a sample of 17 Korsakoff amnesics, 23 alcoholics without Korsakoff's syndrome, and 21 controls with peripheral nerve diseases, matched for intelligence and education. Executive functions were examined for word fluency, the modified Wisconsin Card Sorting Test, an alternate response task, and an "n-back" working memory task. Korsakoff amnesics, but not alcoholics, showed a marked memory impairment. They also scored lower in each of the executive tasks-the alcoholics only in the alternate response task. This task also correlated with the years of the alcohol dependency. First, the authors conclude that Korsakoff's syndrome is associated not only with a memory impairment but also with a global executive deficit. Second, the decline in the ability to alternate between different responses argues for a restricted neurotoxic effect of alcohol on some frontal lobe areas.</description><subject>Addictive behaviors</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Alcoholism</subject><subject>Alcoholism - physiopathology</subject><subject>Alcoholism - psychology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cognitive Impairment</subject><subject>Female</subject><subject>Frontal Lobe</subject><subject>Frontal Lobe - physiopathology</subject><subject>Human</subject><subject>Humans</subject><subject>Inpatient</subject><subject>Korsakoff Syndrome</subject><subject>Korsakoff Syndrome - physiopathology</subject><subject>Korsakoff Syndrome - psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory Disorders - psychology</subject><subject>Middle Aged</subject><subject>Neuropathology</subject><subject>Neuropsychological Tests</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance</subject><subject>Psychopathology. Psychiatry</subject><subject>Short Term Memory</subject><subject>Verbal Learning</subject><issn>0894-4105</issn><issn>1931-1559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MtqGzEUBmBRGmon6Qt0UYaSkEUYR3fNLIObGzFkkXQtjnXBk44lV5pZ-O0rY5O0kJXg8P3niB-hbwTPCGbqCjctrznBYkbUjM04xZ_QlLSM1ESI9jOavoEJOs75FeMykOILmhDailbgZorub1MMA_TVIi5d9XOb_RjM0MWQqy5UjzFl-B29v8jV8zbYFNeugmCr-arEOlNd9yauYt_l9Sk68tBn9_XwnqBftzcv8_t68XT3ML9e1MCVGGrpcGOBtkRIAC-tx0AJVZZTq8ACx95K4bxoCHblg4r6RjKihDWWqaVYshP0Y793k-Kf0eVBv8YxhXJSS8JZIzFnBdE9MinmnJzXm9StIW01wXrXnd5Vo3fVaKI006W7Evp-2Dwu186-Rw5lFXB-AJAN9D5BMF1-dwJLThUp7nLvYAN6k7cG0tCZ3mUzpuTCoIMb_z179rH-n_0FCZaR9w</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Brokate, B</creator><creator>Hildebrandt, H</creator><creator>Eling, P</creator><creator>Fichtner, H</creator><creator>Runge, K</creator><creator>Timm, C</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope></search><sort><creationdate>20030701</creationdate><title>Frontal Lobe Dysfunctions in Korsakoff's Syndrome and Chronic Alcoholism</title><author>Brokate, B ; Hildebrandt, H ; Eling, P ; Fichtner, H ; Runge, K ; Timm, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a475t-6e08da29156aaf6df0a2127d42d7ada40fd65ef5810e50872f863175dcd37b5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Addictive behaviors</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Alcoholism</topic><topic>Alcoholism - physiopathology</topic><topic>Alcoholism - psychology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cognitive Impairment</topic><topic>Female</topic><topic>Frontal Lobe</topic><topic>Frontal Lobe - physiopathology</topic><topic>Human</topic><topic>Humans</topic><topic>Inpatient</topic><topic>Korsakoff Syndrome</topic><topic>Korsakoff Syndrome - physiopathology</topic><topic>Korsakoff Syndrome - psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - psychology</topic><topic>Middle Aged</topic><topic>Neuropathology</topic><topic>Neuropsychological Tests</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance</topic><topic>Psychopathology. Psychiatry</topic><topic>Short Term Memory</topic><topic>Verbal Learning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brokate, B</creatorcontrib><creatorcontrib>Hildebrandt, H</creatorcontrib><creatorcontrib>Eling, P</creatorcontrib><creatorcontrib>Fichtner, H</creatorcontrib><creatorcontrib>Runge, K</creatorcontrib><creatorcontrib>Timm, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><jtitle>Neuropsychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brokate, B</au><au>Hildebrandt, H</au><au>Eling, P</au><au>Fichtner, H</au><au>Runge, K</au><au>Timm, C</au><au>Becker, James T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frontal Lobe Dysfunctions in Korsakoff's Syndrome and Chronic Alcoholism: Continuity or Discontinuity?</atitle><jtitle>Neuropsychology</jtitle><addtitle>Neuropsychology</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>17</volume><issue>3</issue><spage>420</spage><epage>428</epage><pages>420-428</pages><issn>0894-4105</issn><eissn>1931-1559</eissn><abstract>The effect of long-term heavy alcohol consumption on brain functions is still under debate. The authors investigated a sample of 17 Korsakoff amnesics, 23 alcoholics without Korsakoff's syndrome, and 21 controls with peripheral nerve diseases, matched for intelligence and education. Executive functions were examined for word fluency, the modified Wisconsin Card Sorting Test, an alternate response task, and an "n-back" working memory task. Korsakoff amnesics, but not alcoholics, showed a marked memory impairment. They also scored lower in each of the executive tasks-the alcoholics only in the alternate response task. This task also correlated with the years of the alcohol dependency. First, the authors conclude that Korsakoff's syndrome is associated not only with a memory impairment but also with a global executive deficit. Second, the decline in the ability to alternate between different responses argues for a restricted neurotoxic effect of alcohol on some frontal lobe areas.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>12959508</pmid><doi>10.1037/0894-4105.17.3.420</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0894-4105 |
| ispartof | Neuropsychology, 2003-07, Vol.17 (3), p.420-428 |
| issn | 0894-4105 1931-1559 |
| language | eng |
| recordid | cdi_proquest_journals_614386043 |
| source | MEDLINE; APA PsycARTICLES |
| subjects | Addictive behaviors Adult Adult and adolescent clinical studies Aged Alcoholism Alcoholism - physiopathology Alcoholism - psychology Biological and medical sciences Case-Control Studies Cognitive Impairment Female Frontal Lobe Frontal Lobe - physiopathology Human Humans Inpatient Korsakoff Syndrome Korsakoff Syndrome - physiopathology Korsakoff Syndrome - psychology Male Medical sciences Memory Disorders - psychology Middle Aged Neuropathology Neuropsychological Tests Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychomotor Performance Psychopathology. Psychiatry Short Term Memory Verbal Learning |
| title | Frontal Lobe Dysfunctions in Korsakoff's Syndrome and Chronic Alcoholism: Continuity or Discontinuity? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T01%3A31%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Frontal%20Lobe%20Dysfunctions%20in%20Korsakoff's%20Syndrome%20and%20Chronic%20Alcoholism:%20Continuity%20or%20Discontinuity?&rft.jtitle=Neuropsychology&rft.au=Brokate,%20B&rft.date=2003-07-01&rft.volume=17&rft.issue=3&rft.spage=420&rft.epage=428&rft.pages=420-428&rft.issn=0894-4105&rft.eissn=1931-1559&rft_id=info:doi/10.1037/0894-4105.17.3.420&rft_dat=%3Cproquest_cross%3E614386043%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=614386043&rft_id=info:pmid/12959508&rfr_iscdi=true |